107 products were found matching "K06631"!
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Volasertib trihydrochloride
Item number: TGM-T41100-5mg
Description: Volasertib (BI 6727) trihydrochloride is a dihydropteridinone derivative that potently and selectively inhibits Polo-like kinase 1 (PLK1), PLK2, and PLK3, acting as an orally active ATP-competitive inhibitor with an IC50 of 0.87 nM against PLK1, 5 nM against PLK2, and 56 nM against PLK3. Its mechanism...
| Keywords: | BI6727trihydrochloride |
| Application: | Targets polo-like kinase 1 [EC:2.7.11.21] (PLK1) |
| CAS | 946161-17-7 |
| MW: | 728.2 D |
970.00€
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Onvansertib
Item number: TGM-T6247-100mg
Description: Onvansertib (NMS-1286937) is a PLK1 inhibitor (IC50=2 nM) with high selectivity and oral activity. Onvansertib has antitumor activity and inhibits tumor growth. Target: PLK, Apoptosis. Smiles: CN1CCN(CC1)c1ccc(OC(F)(F)F)c(Nc2ncc3CCc4c(nn(CCO)c4-c3n2)C(N)=O)c1. References: Beria I, et al. Bioorg Med...
| Keywords: | NMS-1286937, NMS-P937 |
| Application: | Targets polo-like kinase 1 [EC:2.7.11.21] (PLK1) |
| CAS | 1034616-18-6 |
| MW: | 532.52 D |
From 31.00€
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GSK461364
Item number: TGM-T6282-100mg
Description: GSK461364 (GSK461364A)(Ki=2.2 nM) inhibits purified Plk1 .The specificity of GSK461364 for Plk1 is more than 1000-fold over Plk2/3. Target: PLK. Smiles: C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2ccc(CN3CCN(C)CC3)cc12)c1ccccc1C(F)(F)F. References: Gilmartin AG, et al. Cancer Res, 2009, 69(17), 6969-6977.
| Keywords: | GSK461364A |
| Application: | Plk1 inhibitor |
| CAS | 929095-18-1 |
| MW: | 543.6 D |
From 31.00€
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TAK-960
Item number: TGM-T7200-100mg
Description: TAK-960 is an orally bioavailable, selective inhibitor of Plks with IC50 values of 0.8, 16.9, and 50.2 nM for Plk1, Plk2, and Plk3, respectively. Target: PLK. Smiles: COc1cc(C(=O)NC2CCN(C)CC2)c(F)cc1Nc1ncc2N(C)C(=O)C(F)(F)CN(C3CCCC3)c2n1. References: Klauck P J , Bagby S M , Capasso A , et al. Antitumor...
| Application: | PLK1 inhibitor |
| CAS | 1137868-52-0 |
| MW: | 561.6 D |
From 58.00€
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PLK1 Protein, Human, Recombinant (His)
Item number: TGM-TMPY-04376-100ug
Description: PLK1 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 70.5 kDa and the accession number is P53350.
| Keywords: | PLK, polo-like kinase 1, STPK13 |
| MW: | 70.5 kD |
From 319.00€
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PLK1 Protein, Mouse, Recombinant (His)
Item number: TGM-TMPY-04438-50ug
Description: PLK1 Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 70.6 kDa and the accession number is Q07832.
| Keywords: | STPK13, Plk1, polo-like kinase 1, Plk |
| MW: | 70.6 kD |
497.00€
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Volasertib
Item number: TGM-T6019-100mg
Description: Volasertib (BI 6727) (BI-6727) is a potent inhibitor of PLK1 (IC50: 0.87 nM), inducing mitotic arrest and apoptosis. It also inhibits PLK2/PLK3 (IC50s: 5/56 nM). Target: Apoptosis, PLK. Smiles: CC[C@H]1N(C(C)C)c2nc(Nc3ccc(cc3OC)C(=O)N[C@H]3CC[C@@H](CC3)N3CCN(CC4CC4)CC3)ncc2N(C)C1=O. References: Rudolph...
| Keywords: | BI 6727 |
| Application: | Targets polo-like kinase 1 [EC:2.7.11.21] (PLK1) |
| CAS | 755038-65-4 |
| MW: | 618.81 D |
From 40.00€
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BI 2536
Item number: TGM-T6173-100mg
Description: BI2536 is an effective Plk1 inhibitor (IC50: 0.83 nM). It has 4- and 11-fold greater selectivity than Plk2 and Plk3. Target: Epigenetic Reader Domain, Apoptosis, PLK. Smiles: C(C)[C@H]1N(C=2C(N(C)C1=O)=CN=C(NC3=C(OC)C=C(C(NC4CCN(C)CC4)=O)C=C3)N2)C5CCCC5. References: Steegmaier M, et al. BI 2536, a...
| Application: | pan-BET (bromodomain and extra-terminal motif) family inhibitor, Plk1 inhibitor |
| CAS | 755038-02-9 |
| MW: | 521.65 D |
From 40.00€
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(E/Z)-Rigosertib sodium
Item number: TGM-T6070-100mg
Description: ON-01910 is a non-ATP-competitive PLK1 inhibitor(IC50 of 9 nM, in a cell-free assay). It shows 30-fold greater selectivity against Plk2 and no activity to Plk3. Rigosertib inhibits PI3K/Akt pathway and activates oxidative stress signals. Rigosertib induces apoptosis in various cancer cells.It is a...
| Keywords: | (E/Z) ON-01910 sodium |
| Application: | Plk1 inhibitor |
| CAS | 1225497-78-8 |
| MW: | 473.47 D |
From 34.00€
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Poloxin
Item number: TGM-T16560-100mg
Description: Poloxin is a non-ATP competitive Polo-like Kinase 1 inhibitor targeting the polo-box domain (IC50: appr 4.8 µM). Target: PLK. Smiles: CC(C)C1=C\C(=N\OC(=O)c2ccccc2C)C(C)=CC1=O. References: Yuan J, et al. Polo-box domain inhibitor poloxin activates the spindle assembly checkpoint and inhibits tumor...
| Application: | Plk1 polo-box domain inhibitor |
| CAS | 321688-88-4 |
| MW: | 297.35 D |
From 33.00€
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Rigosertib
Item number: TGM-T16750-10mg
Description: Rigosertib (ON-01910) is a selective, non-ATP-competitive PLK1 inhibitor (IC50: 9 nM) and multi-kinase inhibitor. As a selective anti-cancer agent, Rigosertib induces apoptosis by inhibiting the PI3 kinase/Akt pathway, promotes histone H2AX phosphorylation, and induces G2/M arrest in the cell cycle....
| Keywords: | ON-01910 |
| Application: | Targets polo-like kinase 1 [EC:2.7.11.21] (PLK1) |
| CAS | 592542-59-1 |
| MW: | 451.49 D |
From 34.00€
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Poloppin
Item number: TGM-T24652-10mg
Description: Poloppin is a protein-protein interactions modulator of the mitotic polo-like kinases that acts by targeting mutant KRAS. It works synergistically with Crizotinib, an inhibitor of the c-MET receptor, against mutant KRAS-expressing cancer cells. Target: Others. Smiles:...
| Application: | Plk1-Plk1-binding phosphopeptide protein-peptide interaction inhibitor |
| CAS | 683808-78-8 |
| MW: | 438.24 D |
From 65.00€
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