156 products were found matching "K06619"!
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Asciminib
Item number: LKT-A724091.1
Asciminib is an orally bioavailable, allosteric Bcr-Abl1 tyrosine kinase inhibitor, with antineoplastic activity. Upon administration, asciminib targets and binds to the myristoyl pocket of the Bcr-Abl1 fusion protein at a location that is distinct from the ATP-binding domain, thereby inhibiting the activity of both...
| Keywords: | ABL001, ABL-001, Asciminib free base,... |
| Application: | Allosteric ABL inhibitor, STAMP inhibitor |
| CAS | 1492952-76-7 |
| MW: | 449.84 D |
From 107.00€
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Asciminib Hydrochloride
Item number: LKT-A724092.1
Asciminib is an orally bioavailable, allosteric Bcr-Abl1 tyrosine kinase inhibitor, with antineoplastic activity. Upon administration, asciminib targets and binds to the myristoyl pocket of the Bcr-Abl1 fusion protein at a location that is distinct from the ATP-binding domain, thereby inhibiting the activity of both...
| Keywords: | ABL001 Hydrochloride, ABL001 HCl, Scemblix, ABL001-AAA, C5U34S9XFV,... |
| Application: | Allosteric ABL inhibitor, STAMP inhibitor |
| CAS | 2119669-71-3 |
| MW: | 486.3 D |
From 137.00€
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ABL1 (human), recombinant protein
Item number: ABS-PP-048.20
| Keywords: | Tyrosine-protein kinase ABL1, Abelson murine leukemia viral oncogene homolog 1, Abelson tyrosine-protein kinase 1,... |
| Expressed in: | E.coli |
| Origin: | human |
| MW: | 15 kD |
From 90.00€
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Anti-ABL1
Item number: E-D-AB-10470L.100
c-Abl belongs to the class of tyrosine kinases and is the prototype of a subfamily which includes two members, c-Abl and Arg (Abl-related gene). Both proteins are localized at the cell membrane, actin cytoskeleton and cytosol, and c-Abl is present in the nucleus as well. c-Abl is a non-receptor tyrosine kinase that...
| Keywords: | Anti-ABL, Anti-ABL1, Anti-p150, Anti-Proto-oncogene c-Abl, Anti-Tyrosine-protein kinase ABL1, Anti-Abelson... |
| Application: | IHC |
| Host: | Rabbit |
| Species reactivity: | human |
From 109.00€
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Dasatinib
Item number: Cay11498-10
Dasatinib is a potent inhibitor of the non-receptor tyrosine kinases Abl and Src as well as other members of the Src family. It is effective at sub-nanomolar concentrations, inhibiting Src, Abl, and Lck with IC50 values of 0.05, 0.5, and 0.4 nM, respectively. At nanomolar concentrations, dasatinib also blocks the...
| Keywords: | BMS 354825, Sprycel,... |
| Application: | Tyrosine kinase inhibitor |
| CAS | 302962-49-8 |
| MW: | 488 D |
From 44.00€
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Asciminib hydrochloride
Item number: TGM-T63226-10mg
Description: Asciminib (ABL001) hydrochloride is a selective, potent inhibitor of mutant BCR-ABL1, effectively inhibiting Ba/F3 cell growth with an IC50 of 0.25 nM. Target: Others. Smiles: Cl.O[C@@H]1CCN(C1)c1ncc(cc1-c1cc[nH]n1)C(=O)Nc1ccc(OC(F)(F)Cl)cc1
| Application: | Targets abelson tyrosine-protein kinase 1 [EC:2.7.10.2] (ABL1) |
| CAS | 2119669-71-3 |
| MW: | 486.3 D |
From 77.00€
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Risvodetinib
Item number: TGM-T69979-100mg
Description: Risvodetinib, a potent inhibitor of protein tyrosine kinases, specifically targets the synthesis of Abelson protein kinases (c-Abl1, c-Abl2, and c-kit). Target: Others. Smiles: CC1=C(C=2C=C(C=NC2)C3=NC(NC4=CC(NC(=O)C5=CC=C(CN6CCN(C)CC6)C=C5)=CC=C4C)=NC=C3)ON=C1
| Application: | Targets abelson tyrosine-protein kinase 1 [EC:2.7.10.2] (ABL1) |
| CAS | 2031185-00-7 |
| MW: | 574.68 D |
From 1,820.00€
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Vodobatinib
Item number: TGM-T8882-100mg
Description: Vodobatinib (K-0706) is a novel 3rd generation (3G) TKI effective against wild-type and mutated BCR-ABL1 with limited off-target activity. Target: Bcr-Abl. Smiles: Cc1ccc(cc1C#Cc1cnc2ccccc2c1)C(=O)NNC(=O)c1c(C)cccc1Cl
| Keywords: | K-0706 |
| Application: | Targets abelson tyrosine-protein kinase 1 [EC:2.7.10.2] (ABL1) |
| CAS | 1388803-90-4 |
| MW: | 453.92 D |
From 31.00€
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C-ABL/ABL1 Protein, Human, Recombinant (GST)
Item number: TGM-TMPY-04396-100ug
Description: c-Abl belongs to the class of tyrosine kinases and is the prototype of a subfamily which includes two members, c-Abl and Arg (Abl-related gene). Both proteins are localized at the cell membrane, actin cytoskeleton and cytosol, and c-Abl is present in the nucleus as well. c-Abl is a non-receptor tyrosine...
| Keywords: | bcr/abl, p150, c-ABL, v-abl, JTK7, ABL, ABL proto-oncogene 1, non-receptor tyrosine kinase, c-ABL1 |
| MW: | 74 kD |
From 236.00€
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Nilotinib-d6
Item number: TGM-T12224-10mg
Description: Nilotinib D6 is a deuterium labeled Nilotinib which is an orally available inhibitor of Bcr-Abl tyrosine kinase ,and with antineoplastic activity. Smiles: [2H]c1c([2H])c(c(Nc2nccc(n2)-c2cccnc2)c([2H])c1C(=O)Nc1cc(cc(c1)C(F)(F)F)-n1cnc(C)c1)C([2H])([2H])[2H]. References: Weisberg E, et al. Beneficial...
| Keywords: | AMN107 D6 |
| Application: | Internal standard, GC, LC-MS |
| CAS | 1268356-17-7 |
| MW: | 535.55 D |
From 276.00€
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AG957
Item number: TGM-T21785-1mg
Description: Tyrphostin AG957, a tyrosine kinase inhibitor with anti-BCR/ABL tyrosine kinase activity restores beta1 integrin-mediated adhesion and inhibitory signaling in chronic myelogenous leukemia hematopoietic progenitors[1]. Target: Bcr-Abl. Smiles: COC(=O)c1ccc(NCc2cc(O)ccc2O)cc1. References: Bhatia R, Munthe...
| Application: | Tyrosine kinase inhibitor |
| CAS | 140674-76-6 |
| MW: | 273.28 D |
From 91.00€
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Flumatinib
Item number: TGM-T4320-100mg
Description: Flumatinib (HHGV678) is an orally bioavailable tyrosine kinase inhibitor with potential antineoplastic activity. Target: Bcr-Abl, PDGFR, c-Kit. Smiles: CN1CCN(Cc2ccc(cc2C(F)(F)F)C(=O)Nc2cnc(C)c(Nc3nccc(n3)-c3cccnc3)c2)CC1. References: Luo H, et al. HH-GV-678, a novel selective inhibitor of Bcr-Abl,...
| Keywords: | HHGV678 |
| Application: | Bcr-Abl inhibitor |
| CAS | 895519-90-1 |
| MW: | 562.59 D |
From 31.00€
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