169 products were found matching "K06619"!
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BBT594
Item number: Cay41359-10
BBT594 is an inhibitor of Bcr-AblT315I (IC50 = 44 nM), a form of the Bcr-Abl fusion protein containing a tyrosine-to-isoleucine substitution at position 315. It decreases proliferation in mouse Ba/F3 hematopoietic cells expressing Bcr-AblT315I (GI50 = 117 nM). BBT594 (1 or 5 µM) also inhibits phosphorylation of Jak2...
| Keywords: | NVP-BBT594,... |
| Application: | Bcr-AblT315I inhibitor |
| CAS | 882405-89-2 |
| MW: | 569.6 D |
From 67.00€
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AG957
Item number: TGM-T21785-1mg
Description: Tyrphostin AG957, a tyrosine kinase inhibitor with anti-BCR/ABL tyrosine kinase activity restores beta1 integrin-mediated adhesion and inhibitory signaling in chronic myelogenous leukemia hematopoietic progenitors[1]. Target: Bcr-Abl. Smiles: COC(=O)c1ccc(NCc2cc(O)ccc2O)cc1. References: Bhatia R, Munthe...
| Application: | Tyrosine kinase inhibitor |
| CAS | 140674-76-6 |
| MW: | 273.28 D |
From 89.00€
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Flumatinib
Item number: TGM-T4320-100mg
Description: Flumatinib (HHGV678) is an orally bioavailable tyrosine kinase inhibitor with potential antineoplastic activity. Target: Bcr-Abl, PDGFR, c-Kit. Smiles: CN1CCN(Cc2ccc(cc2C(F)(F)F)C(=O)Nc2cnc(C)c(Nc3nccc(n3)-c3cccnc3)c2)CC1. References: Luo H, et al. HH-GV-678, a novel selective inhibitor of Bcr-Abl,...
| Keywords: | HHGV678 |
| Application: | Bcr-Abl inhibitor |
| CAS | 895519-90-1 |
| MW: | 562.59 D |
From 31.00€
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BGG463
Item number: TGM-T4618-100mg
Description: BGG463 (K 0859) can inhibit c-ABL-T334I, BCR-ABL and BCR-ABL-T315I variants with a 50% inhibitory concentration (IC50) of 0.25 µM, 0.09 µM and 0.590 µM, respectively. Target: CDK, Bcr-Abl. Smiles: CN1CCN(Cc2ccc(NC(=O)c3cccc4cc(Oc5cc(NC(C)=O)ncn5)ccc34)cc2C(F)(F)F)CC1. References: Alexander LT, et al....
| Keywords: | K 0859 |
| Application: | BBT594 (Bcr-Abl.T315I inhibitor) derivative |
| CAS | 890129-26-7 |
| MW: | 578.58 D |
From 55.00€
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Asciminib hydrochloride
Item number: TGM-T63226-10mg
Description: Asciminib (ABL001) hydrochloride is a selective, potent inhibitor of mutant BCR-ABL1, effectively inhibiting Ba/F3 cell growth with an IC50 of 0.25 nM. Target: Others. Smiles: Cl.O[C@@H]1CCN(C1)c1ncc(cc1-c1cc[nH]n1)C(=O)Nc1ccc(OC(F)(F)Cl)cc1
| Application: | Targets abelson tyrosine-protein kinase 1 [EC:2.7.10.2] (ABL1) |
| CAS | 2119669-71-3 |
| MW: | 486.3 D |
From 77.00€
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Vodobatinib
Item number: TGM-T8882-100mg
Description: Vodobatinib (K-0706) is a novel 3rd generation (3G) TKI effective against wild-type and mutated BCR-ABL1 with limited off-target activity. Target: Bcr-Abl. Smiles: Cc1ccc(cc1C#Cc1cnc2ccccc2c1)C(=O)NNC(=O)c1c(C)cccc1Cl
| Keywords: | K-0706 |
| Application: | Targets abelson tyrosine-protein kinase 1 [EC:2.7.10.2] (ABL1) |
| CAS | 1388803-90-4 |
| MW: | 453.92 D |
From 32.00€
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C-ABL/ABL1 Protein, Human, Recombinant (GST)
Item number: TGM-TMPY-04396-100ug
Description: c-Abl belongs to the class of tyrosine kinases and is the prototype of a subfamily which includes two members, c-Abl and Arg (Abl-related gene). Both proteins are localized at the cell membrane, actin cytoskeleton and cytosol, and c-Abl is present in the nucleus as well. c-Abl is a non-receptor tyrosine...
| Keywords: | bcr/abl, p150, c-ABL, v-abl, JTK7, ABL, ABL proto-oncogene 1, non-receptor tyrosine kinase, c-ABL1 |
| MW: | 74 kD |
From 232.00€
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GNF-2
Item number: TGM-T1817-100mg
Description: GNF-2 is a highly selective non-ATP competitive inhibitor of Bcr-Abl. Target: SARS-CoV, Bcr-Abl. Smiles: NC(=O)c1cccc(c1)-c1cc(Nc2ccc(OC(F)(F)F)cc2)ncn1. References: Adrián FJ, et al. Nat Chem Biol, 2006, 2(2), 95-102
| Keywords: | GNF2 |
| Application: | Bcr-abl inhibitor |
| CAS | 778270-11-4 |
| MW: | 374.32 D |
From 31.00€
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GNF-5
Item number: TGM-T1803-100mg
Description: GNF-5 is a specific non-ATP competitive inhibitor of Bcr-Abl (IC50: 0.22±0.1 uM, Wild-type Abl). It is an analog of GNF-2 with improved pharmacokinetic properties. Target: SARS-CoV, Bcr-Abl. Smiles: N(C1=CC(=NC=N1)C2=CC(C(NCCO)=O)=CC=C2)C3=CC=C(OC(F)(F)F)C=C3. References: Zhang J, et al. Nature. 2010,...
| Keywords: | GNF 5 |
| Application: | BCR-Abl inhibitor |
| CAS | 778277-15-9 |
| MW: | 418.37 D |
From 33.00€
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Nilotinib-d6
Item number: TGM-T12224-10mg
Description: Nilotinib D6 is a deuterium labeled Nilotinib which is an orally available inhibitor of Bcr-Abl tyrosine kinase ,and with antineoplastic activity. Smiles: [2H]c1c([2H])c(c(Nc2nccc(n2)-c2cccnc2)c([2H])c1C(=O)Nc1cc(cc(c1)C(F)(F)F)-n1cnc(C)c1)C([2H])([2H])[2H]. References: Weisberg E, et al. Beneficial...
| Keywords: | AMN107 D6 |
| Application: | Internal standard, GC, LC-MS |
| CAS | 1268356-17-7 |
| MW: | 535.55 D |
From 272.00€
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Tyrosine-protein kinase ABL1 (ABL1), partial, human,...
Item number: CSB-RP043554h.1
Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 4-194aa. Protein Length: Partial. Tag Info: N-terminal GST-tagged. Target Protein Sequence: ICLKLVGCKS KKGLSSSSSC YLEEALQRPV ASDFEPQGLS EAARWNSKEN LLAGPSENDP NLFVALYDFV ASGDNTLSIT KGEKLRVLGY NHNGEWCEAQ TKNGQGWVPS NYITPVNSLE KHSWYHGPVS RNAAEYLLSS...
| Keywords: | ABL, p150, ABL1, Proto-oncogene c-Abl, Tyrosine-protein kinase ABL1, Abelson tyrosine-protein kinase 1, Abelson murine... |
| Application: | Activity not tested |
| Expressed in: | E.coli |
| Origin: | human |
| MW: | 48.1 kD |
From 213.00€
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BGG463
Item number: Cay41146-1
BGG463 is a derivative of BBT594, an inhibitor of the fusion protein Bcr-AblT315I.Formal Name: 6-[[6-(acetylamino)-4-pyrimidinyl]oxy]-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-1-naphthalenecarboxamide. CAS Number: 890129-26-7. Synonyms: K03859, NVP-BGG463. Molecular Formula: C30H29F3N6O3....
| Keywords: | K03859, NVP-BGG463,... |
| Application: | BBT594 (Bcr-Abl.T315I inhibitor) derivative |
| CAS | 890129-26-7 |
| MW: | 578.6 D |
From 47.00€
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