- Search results for K06067
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312 products were found matching "K06067"!
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Item number: Cay10009929-100
SAHA is a histone deacetylase (HDAC) inhibitor that binds directly to the catalytic site of the enzyme thereby blocking substrate access. It inhibits class I, II, and IV HDACs at 50-200 nM and arrests cell growth in a wide variety of transformed cells in culture at 2.5-5.0 µM.Formal Name:...
Keywords: | Suberoylanilide Hydroxamic Acid, Vorinostat, N1-hydroxy-N8-phenyl-octanediamide |
Application: | HDAC inhibitor |
CAS | 149647-78-9 |
MW: | 264.3 D |
From 34.00€
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Item number: BPS-50051
Active human HDAC1, GenBank Accession No. NM_004964, full length with C-terminal HIS-DDDDK tag (FLAG), MW= 56 kDa, expressed in baculovirus expression system.
Keywords: | HD1, Histone deacetylase 1, Protein deacetylase HDAC1, Protein decrotonylase HDAC1, |
Application: | Enzyme kinetics, inhibitor screening |
MW: | 56 kD |
716.00€
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Item number: Cay89730-1
Trichostatin A is a potent, reversible inhibitor of class I, II, and IV histone deacetylases (HDACs). In human Jurkat T cells, trichostatin A arrests cell cycle progression in G1 and inhibits the activity of HDAC1 with an IC50 value of 70 nM. Trichostatin A selectively inhibits the removal of acetyl groups from the...
Keywords: | TSA, 7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6R-dimethyl-7-oxo-2E,4E-heptadienamide |
Application: | HDAC inhibitor |
CAS | 58880-19-6 |
MW: | 302.4 D |
From 76.00€
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Item number: TGM-T21551-50mg
Description: 2-hexyl-4-Pentynoic Acid, a valproic acid (VPA) derivatives, is a potent and robust HDACs inhibitor with IC50 value of 13 µM. Target: HDAC. Smiles: CCCCCCC(CC#C)C(O)=O. References: Zhao J, et al. Identification of HIVEP2 as a dopaminergic transcription factor related to substance use disorders in rats...
Application: | HDAC inhibitor |
CAS | 96017-59-3 |
MW: | 182.26 D |
From 58.00€
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Item number: TGM-T21715-1mg
Description: BRD6688 is a selective HDAC2 inhibitor that acts by enhancing the learning and memory processes. Target: HDAC. Smiles: Nc1ccc(cc1NC(=O)N1CCCC1)-c1ccncc1. References: Kinetically selective inhibitors of histone deacetylase 2 (HDAC2) as cognition enhancers[J]. Chemical Science, 2014, 6(1):804-815.
Application: | HDAC2 inhibitor, nootropic |
CAS | 1404562-17-9 |
MW: | 282.34 D |
From 96.00€
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Item number: TGM-T21749-50mg
Description: 4-Iodo-SAHA (1k), an orally active inhibitor of both class I and class II histone deacetylase (HDAC), exhibits EC50 values of 1.1, 0.95, 0.12, 0.24, 0.85, and 1.3 µM for Skbr3, HT29, U937, JA16, and HL60 cell lines, respectively. This compound holds potential for cancer research purposes [1]. Target:...
Application: | HDAC inhibitor |
CAS | 1219807-87-0 |
MW: | 390.22 D |
From 218.00€
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Item number: TGM-T21806-1mg
Description: HNHA is an inhibitor of HDAC. Target: HDAC. Smiles: ONC(=O)CCCCCCSc1ccc2ccccc2c1. References: Dong H K , Lee J , Kim K N , et al. Anti-tumor activity of N-hydroxy-7-(2-naphthylthio) heptanomide, a novel histone deacetylase inhibitor[J]. Biochemical & Biophysical Research Communications, 2007,...
Application: | HDAC inhibitor |
CAS | 926908-04-5 |
MW: | 303.42 D |
From 62.00€
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Item number: TGM-T3204-100mg
Description: BML-210 (CAY10433) is a new-type HDAC inhibitor. Target: HDAC, Apoptosis. Smiles: Nc1ccccc1NC(=O)CCCCCCC(=O)Nc1ccccc1. References: Jayathilaka N, et al. Nucleic Acids Res. 2012 Jul,40(12):5378-88.
Keywords: | CAY10433 |
Application: | HDAC inhibitor |
CAS | 537034-17-6 |
MW: | 339.43 D |
From 34.00€
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Item number: TGM-T3205-100mg
Description: UF010 is a potent and selective HADC inhibitor with IC50 ~0.06 µM, 0.1 µM, 0.5 µM and 1.5 µM for HDACs 3, 2, 1 and 8, respectively. Target: HDAC. Smiles: CCCCNNC(=O)c1ccc(Br)cc1. References: Wang Y, et al. Identification of histone deacetylase inhibitors with benzoylhydrazide scaffold that selectively...
Application: | Class I HDAC inhibitor |
CAS | 537672-41-6 |
MW: | 271.15 D |
From 31.00€
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Item number: TGM-T3206-100mg
Description: NKL 22 (Histone Deacetylase Inhibitor IV) is an effective Histone Deacetylase Inhibitor. Target: HDAC. Smiles: Nc1ccccc1NC(=O)CCCCCC(=O)Nc1ccccc1. References: D Herman et al. Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia. Nat Chem Biol, 2006 Oct, 2(10):551-8.
Keywords: | PAOA, Histone Deacetylase Inhibitor IV |
Application: | HDAC1 / HDAC3 inhibitor |
CAS | 537034-15-4 |
MW: | 325.4 D |
From 31.00€
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Item number: TGM-T3516-10mg
Description: EDO-S101 (Tinostamustine) is a pan HDAC inhibitor with IC50 values of 9, 9 and 25 nM for HDAC1, HDAC2 and HDAC3 , respectively. Target: HDAC. Smiles: CN1C=2C(=CC(N(CCCl)CCCl)=CC2)N=C1CCCCCCC(NO)=O. References: Mehrling T, et al. The Alkylating-HDAC Inhibition Fusion Principle: Taking Chemotherapy to the...
Keywords: | Tinostamustine, Minomustine |
Application: | Targets histone deacetylase 1/2 [EC:3.5.1.98] (HDAC1_2) |
CAS | 1236199-60-2 |
MW: | 415.36 D |
From 40.00€
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Item number: TGM-T35762-2mg
Description: MC1742 is an inhibitor of class I histone deacetylases (HDACs, IC50s = 0.1, 0.11, 0.02, and 0.61 µM for HDAC1, -2, -3, and -8, respectively) and class IIb HDACs (IC50s = 7 and 40 nM for HDAC6 and HDAC10, respectively).1 It is selective for class I and class IIb over class IIa HDACs (IC50s = >50 µM for...
Application: | Class I HDAC inhibitor |
CAS | 1776116-74-5 |
MW: | 395.47 D |
98.00€
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