312 products were found matching "K06067"!

1 from 26 pages
No results were found for the filter!
SAHA
SAHA

Item number: Cay10009929-100

SAHA is a histone deacetylase (HDAC) inhibitor that binds directly to the catalytic site of the enzyme thereby blocking substrate access. It inhibits class I, II, and IV HDACs at 50-200 nM and arrests cell growth in a wide variety of transformed cells in culture at 2.5-5.0 µM.Formal Name:...
Keywords: Suberoylanilide Hydroxamic Acid, Vorinostat, N1-hydroxy-N8-phenyl-octanediamide
Application: HDAC inhibitor
CAS 149647-78-9
MW: 264.3 D
From 34.00€ *
Review
HDAC-1, active human recombinant protein
HDAC-1, active human recombinant protein

Item number: BPS-50051

Active human HDAC1, GenBank Accession No. NM_004964, full length with C-terminal HIS-DDDDK tag (FLAG), MW= 56 kDa, expressed in baculovirus expression system.
Keywords: HD1, Histone deacetylase 1, Protein deacetylase HDAC1, Protein decrotonylase HDAC1,
Application: Enzyme kinetics, inhibitor screening
MW: 56 kD
716.00€ *
Review
Trichostatin A
Trichostatin A

Item number: Cay89730-1

Trichostatin A is a potent, reversible inhibitor of class I, II, and IV histone deacetylases (HDACs). In human Jurkat T cells, trichostatin A arrests cell cycle progression in G1 and inhibits the activity of HDAC1 with an IC50 value of 70 nM. Trichostatin A selectively inhibits the removal of acetyl groups from the...
Keywords: TSA, 7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6R-dimethyl-7-oxo-2E,4E-heptadienamide
Application: HDAC inhibitor
CAS 58880-19-6
MW: 302.4 D
From 76.00€ *
Review
2-hexyl-4-Pentynoic Acid
2-hexyl-4-Pentynoic Acid

Item number: TGM-T21551-50mg

Description: 2-hexyl-4-Pentynoic Acid, a valproic acid (VPA) derivatives, is a potent and robust HDACs inhibitor with IC50 value of 13 µM. Target: HDAC. Smiles: CCCCCCC(CC#C)C(O)=O. References: Zhao J, et al. Identification of HIVEP2 as a dopaminergic transcription factor related to substance use disorders in rats...
Application: HDAC inhibitor
CAS 96017-59-3
MW: 182.26 D
From 58.00€ *
Review
BRD6688
BRD6688

Item number: TGM-T21715-1mg

Description: BRD6688 is a selective HDAC2 inhibitor that acts by enhancing the learning and memory processes. Target: HDAC. Smiles: Nc1ccc(cc1NC(=O)N1CCCC1)-c1ccncc1. References: Kinetically selective inhibitors of histone deacetylase 2 (HDAC2) as cognition enhancers[J]. Chemical Science, 2014, 6(1):804-815.
Application: HDAC2 inhibitor, nootropic
CAS 1404562-17-9
MW: 282.34 D
From 96.00€ *
Review
4-iodo-SAHA
4-iodo-SAHA

Item number: TGM-T21749-50mg

Description: 4-Iodo-SAHA (1k), an orally active inhibitor of both class I and class II histone deacetylase (HDAC), exhibits EC50 values of 1.1, 0.95, 0.12, 0.24, 0.85, and 1.3 µM for Skbr3, HT29, U937, JA16, and HL60 cell lines, respectively. This compound holds potential for cancer research purposes [1]. Target:...
Application: HDAC inhibitor
CAS 1219807-87-0
MW: 390.22 D
From 218.00€ *
Review
HNHA
HNHA

Item number: TGM-T21806-1mg

Description: HNHA is an inhibitor of HDAC. Target: HDAC. Smiles: ONC(=O)CCCCCCSc1ccc2ccccc2c1. References: Dong H K , Lee J , Kim K N , et al. Anti-tumor activity of N-hydroxy-7-(2-naphthylthio) heptanomide, a novel histone deacetylase inhibitor[J]. Biochemical & Biophysical Research Communications, 2007,...
Application: HDAC inhibitor
CAS 926908-04-5
MW: 303.42 D
From 62.00€ *
Review
BML-210
BML-210

Item number: TGM-T3204-100mg

Description: BML-210 (CAY10433) is a new-type HDAC inhibitor. Target: HDAC, Apoptosis. Smiles: Nc1ccccc1NC(=O)CCCCCCC(=O)Nc1ccccc1. References: Jayathilaka N, et al. Nucleic Acids Res. 2012 Jul,40(12):5378-88.
Keywords: CAY10433
Application: HDAC inhibitor
CAS 537034-17-6
MW: 339.43 D
From 34.00€ *
Review
UF010
UF010

Item number: TGM-T3205-100mg

Description: UF010 is a potent and selective HADC inhibitor with IC50 ~0.06 µM, 0.1 µM, 0.5 µM and 1.5 µM for HDACs 3, 2, 1 and 8, respectively. Target: HDAC. Smiles: CCCCNNC(=O)c1ccc(Br)cc1. References: Wang Y, et al. Identification of histone deacetylase inhibitors with benzoylhydrazide scaffold that selectively...
Application: Class I HDAC inhibitor
CAS 537672-41-6
MW: 271.15 D
From 31.00€ *
Review
NKL 22
NKL 22

Item number: TGM-T3206-100mg

Description: NKL 22 (Histone Deacetylase Inhibitor IV) is an effective Histone Deacetylase Inhibitor. Target: HDAC. Smiles: Nc1ccccc1NC(=O)CCCCCC(=O)Nc1ccccc1. References: D Herman et al. Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia. Nat Chem Biol, 2006 Oct, 2(10):551-8.
Keywords: PAOA, Histone Deacetylase Inhibitor IV
Application: HDAC1 / HDAC3 inhibitor
CAS 537034-15-4
MW: 325.4 D
From 31.00€ *
Review
EDO-S101
EDO-S101

Item number: TGM-T3516-10mg

Description: EDO-S101 (Tinostamustine) is a pan HDAC inhibitor with IC50 values of 9, 9 and 25 nM for HDAC1, HDAC2 and HDAC3 , respectively. Target: HDAC. Smiles: CN1C=2C(=CC(N(CCCl)CCCl)=CC2)N=C1CCCCCCC(NO)=O. References: Mehrling T, et al. The Alkylating-HDAC Inhibition Fusion Principle: Taking Chemotherapy to the...
Keywords: Tinostamustine, Minomustine
Application: Targets histone deacetylase 1/2 [EC:3.5.1.98] (HDAC1_2)
CAS 1236199-60-2
MW: 415.36 D
From 40.00€ *
Review
MC1742
MC1742

Item number: TGM-T35762-2mg

Description: MC1742 is an inhibitor of class I histone deacetylases (HDACs, IC50s = 0.1, 0.11, 0.02, and 0.61 µM for HDAC1, -2, -3, and -8, respectively) and class IIb HDACs (IC50s = 7 and 40 nM for HDAC6 and HDAC10, respectively).1 It is selective for class I and class IIb over class IIa HDACs (IC50s = >50 µM for...
Application: Class I HDAC inhibitor
CAS 1776116-74-5
MW: 395.47 D
98.00€ *
Review
1 from 26 pages