63 products were found matching "K06059"!
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TAPI-0
Item number: TGM-T70664-100mg
Description: TAPI-0 is a matrix metalloprotease (MMP) and TACE inhibitor. Target: Others. Smiles: C([C@H](NC(C(CC(NO)=O)CC(C)C)=O)C(N[C@H](C(N)=O)C)=O)C1=CC2=C(C=C1)C=CC=C2
| Application: | TACE inhibitor |
| CAS | 143457-40-3 |
| MW: | 456.53 D |
From 1,520.00€
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ADAM17 Protein, Rat, Recombinant (His)
Item number: TGM-TMPY-03308-20ug
Description: ADAM17 is a member of the ADAM protein family of disintegrins and metalloproteases. ADAM17 is ubiquitously expressed in the human colon, with increased activity in the colonic mucosa of patients with ulcerative colitis, a main form of inflammatory bowel disease. The expression of ADAM17 may be inhibited...
| Keywords: | ADAM metallopeptidase domain 17 |
| MW: | 63 kD |
599.00€
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TNF Protease Inhibitor 2
Item number: TGM-TQ0129-100mg
Description: TAPI-2 is a broad-spectrum inhibitor of MMP (IC50: 20 µM), tumour necrosis factoralpha-converting enzyme (TACE) and a disintegrin and metalloproteinase (ADAM). Target: MMP. Smiles: CC(C)CC(CC(=O)NO)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)NCCN)C(C)(C)C. References: Kruse MN, et al. Human meprin alpha and beta...
| Keywords: | TAPI-2 |
| Application: | TNF Protease inhibitor |
| CAS | 187034-31-7 |
| MW: | 415.53 D |
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(S,S)-TAPI-1
Item number: TGM-T63390-1mg
Description: (S,S)-TAPI-1, an isomer of TAPI-1, is a metalloproteinase (MMP) inhibitor and a TACE (ADAM17) inhibitor known for its potent inhibition of various cell surface protein shedding. Target: Others. Smiles: CC(C)CC(CC(=O)NO)C(=O)NC(Cc1ccc2ccccc2c1)C(=O)NC(C)C(=O)NCCN
| Application: | ADAM17 inhibitor |
| CAS | 171235-71-5 |
| MW: | 499.6 D |
From 371.00€
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Apratastat
Item number: TGM-T14312-10mg
Description: Apratastat is an orally active, potent, and reversible dual inhibitor of tumor necrosis factor-alpha converting enzyme (TACE) and matrix metalloproteinases (MMPs) and it also can potently inhibit the release of TNF-alpha in vitro, ex vivo, and in vivo with IC50s of 144 ng/mL in vitro and 81.7 ng/mL ex...
| Application: | Targets disintegrin and metalloproteinase domain-containing protein 17 (ADAM17, TACE, CD156b) |
| CAS | 287405-51-0 |
| MW: | 414.5 D |
From 147.00€
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Human ADAM17(581-642) Protein, hFc Tag
Item number: DIM-PME101098.10
Recombinant human ADAM17(581-642) Protein with C-terminal human Fc tag. ADAM17(Phe581-Glu642) hFc(Glu99-Ala330), Protein function: Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form (PubMed:9034191). Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface...
| Keywords: | CSVP, TACE, CD156B, NISBD1 |
| Expressed in: | Human cells |
| Origin: | human |
| CAS | 12 |
| MW: | 33.1 kD |
From 100.00€
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Human ADAM17(581-642) Protein, mFc Tag
Item number: DIM-PME101418.10
Recombinant human ADAM17(581-642) Protein with C-terminal mouse Fc tag. ADAM17(Phe581-Glu642) mFc(Pro99-Lys330), Protein function: Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form (PubMed:9034191). Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface...
| Keywords: | CSVP, TACE, CD156B, NISBD1 |
| Expressed in: | Human cells |
| Origin: | human |
| CAS | 12 |
| MW: | 33.2 kD |
From 100.00€
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Human ADAM17 Protein, hFc Tag
Item number: DIM-PME101486.10
Recombinant human ADAM17 Protein with C-terminal human Fc tag. ADAM17(Pro18-Asn671) hFc(Glu99-Ala330), Protein function: Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form (PubMed:9034191). Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface...
| Keywords: | CSVP, TACE, CD156B, NISBD1 |
| Expressed in: | Human cells |
| Origin: | human |
| CAS | 12 |
| MW: | 100.2 kD |
From 143.00€
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Anti-ADAM17
Item number: CSB-PA261035.100
Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: ADAM17. Antigen Species: Human
| Keywords: | Anti-CSVP, Anti-ADAM17, Anti-CD156b, Anti-ADAM 17, Anti-TNF-alpha convertase, Anti-Snake venom-like protease,... |
| Application: | ELISA, IHC |
| Host: | Rabbit |
| Species reactivity: | human, mouse, rat |
From 167.00€
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TAPI-1
Item number: Cay18505-500
TNF-alpha converting enzyme (TACE, also known as ADAM17) is a zinc metalloprotease that cleaves the membrane-bound precursor of TNF-alpha to give the mature soluble form of TNF-alpha. It also mediates the proteolytic release of several other cell-surface proteins, including TNF-alpha receptors (TNFRs). TAPI-1, known...
| Keywords: | TAPI, N-[2-[2-(hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-(2-naphthalenyl)-L-alanyl-N-(2-aminoethyl)-... |
| Application: | ADAM17 inhibitor |
| CAS | 171235-71-5 |
| MW: | 499.6 D |
From 204.00€
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TAPI-2
Item number: Cay14695-1
The extracellular domains of many different types of transmembrane proteins, including growth factors, growth factor receptors and cell adhesion molecules, are proteolytically released (shed) in response to environmental cues. TNF protease inhibitor 2 (TAPI-2) is a broad-spectrum inhibitor of TNF-alpha converting...
| Keywords: | TNF Protease Inhibitor 2,... |
| Application: | TAPI-2 Inhibitor |
| CAS | 187034-31-7 |
| MW: | 415.5 D |
From 205.00€
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TMI-005
Item number: Cay29016-1
TMI-005 is an inhibitor of disintegrin and metalloproteinase domain-containing protein 17/TNF-alpha converting enzyme (ADAM17/TACE), matrix metalloproteinase-1 (MMP-1), and MMP-13 (IC50s = 20, 33, and 8.1 nM, respectively). It inhibits LPS-induced TNF-alpha release in isolated human whole blood (IC50 = 144 ng/ml)....
| Keywords: | Apratastat, (3S)-N-hydroxy-4-[[4-[(4-hydroxy-2-butyn-1-yl)oxy]phenyl]sulfonyl]-2,2-dimethyl-3-thiomorpholinecarboxamide |
| Application: | ADAM17 / MMP-1 / MMP-13 inhibitor |
| CAS | 287405-51-0 |
| MW: | 414.5 D |
From 61.00€
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