36 products were found matching "K05954"!

Description: Manumycin A is an antibiotic with anticancer activity and is a mammalian thioredoxin reductase-1 (TrxR-1) inhibitor.Manumycin A inhibits the production of IL-1beta, IL-6, and IL-8 in TNF alpha-stimulated THP-1 cells and peripheral blood mononuclear cells in a dose-dependent manner, inducing apoptosis....

Description: LB42708 is an orally active farnesyltransferase (FTase) inhibitor (IC50: 0.8/1.2/2.0 nM toward H/N/K-ras). Target: Transferase. Smiles: C(=O)(C=1C(=CN(CC=2N(CC3=CC=C(Br)C=C3)C=NC2)C1)C=4C5=C(C=CC4)C=CC=C5)N6CCOCC6. References: Na HJ, et al. J Immunol. 2004, 173(2), 1276-1283.

Description: Ftase Inhibitor III, derived from a phenotypic screen, functions as an anion-dependent inhibitor of Farnesyltransferase. Target: Others. Smiles: Cc1nn(C)c(C)c1C(=O)N1CCN(Cc2nc3ccccc3n2CC(C)(C)C)CC1. References: Bukhtiyarova M, et al. Discovery of an Anion-Dependent Farnesyltransferase Inhibitor from a...

Description: FTI 277 TFA is a prodrug form of FTI 276 that inhibits farnesyltransferase (FTase) (IC50 = 0.5 nM). Inhibits H-Ras and K-Ras processing in whole cells (IC50 values are 0.1 and 10µM respectively) and disrupts constitutive H-Ras-specific activation of MAPK. Causes significant antiproliferative effects in...

Description: Arglabin ((+)-Arglabin) is a natural product isolated from Artemisia glabella, is a NLRP3 inflammasome inhibitor, has anti-atherogenic and anticancer effects. Target: Transferase, NOD, NOD-like Receptor (NLR), Autophagy. Smiles: [H][C@@]12CC[C@]3(C)O[C@@]33CC=C(C)[C@]3([H])[C@@]1([H])OC(=O)C2=C....

Description: B 581 is an inhibitor that specifically blocks farnesylated. Target: Others. Smiles: [C@H](CC1=CC=CC=C1)(C(N[C@@H](CCSC)C(O)=O)=O)NC[C@@H](NC[C@H](CS)N)[C@@H](C)C. References: Cox AD, Garcia AM, Westwick JK, Kowalczyk JJ, Lewis MD, Brenner DA, Der CJ. The CAAX peptidomimetic compound B581 specifically...

ABT-100 is an inhibitor of farnesyltransferase (FTase). It inhibits Ras farnesylation but not Rap1A geranylgeranylation in HepG2 and Huh7 cells when used at a concentration of 20 µM. ABT-100 (2-20 µM) inhibits the proliferation of the same cells. In vivo, ABT-100 (39 mg/kg per day) increases body weight and percent...

Antibiotic, Potent, selective and competitive cell-permeable rasfarnesyltransferase inhibitor (IC50 = 30 nM), Does not affect geranylgeranyltransferase (IC50 = 180 µM), Inhibition is competitive with respect to farnesyl pyrophosphate and non-competitive with respect to Ras, Neutral sphingomyelinase inhibitor, Blocks...

Manumycin A is an antibiotic that acts as a potent and selective farnesyltransferase (FTase) inhibitor with anti-tumor activity. It inhibits rat brain FTase with a Ki value of 1.2 µM, thereby preventing Ras activation which requires farnesylation at the C-terminus for membrane attachment. It exhibits significant...

Farnesyltransferase drives the post-translational farnesylation of a number of target proteins, including Ras, a component of the MAPK and Akt signaling pathways involved in cell proliferation, and Ras homolog enriched in brain (Rheb), which stimulates mTOR activity. By arresting growth, farnesyltransferase...

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human FNTb. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human FNTb. Next,...

White to off-white solid. Soluble in dry DMSO, 100% ethanol or methanol. Insoluble in water. Anticancer compound, Farnesyltransferase inhibitor, Potent anti-inflammatory agent, NF-kappaB inhibitor, Inflammasome inhibitor, Antiatherogenic. Prevents the accumulation of lipid containing plaques in arteries.