154 products were found matching "K05658"!
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Reversin 121
Item number: TGM-T72921-1mg
Description: Reversin 121, a P-glycoprotein inhibitor, enhances MDR1's ATPase activity and counteracts P-glycoprotein-mediated multidrug resistance, making it useful in cancer research. Smiles: [C@@H](C(N[C@@H](CCCCNC(OCC1=CC=CC=C1)=O)C(OC(C)(C)C)=O)=O)(CC(OCC2=CC=CC=C2)=O)NC(OC(C)(C)C)=O
| Application: | MDR1 modulator, chemosensitizer |
| CAS | 174630-04-7 |
| MW: | 641.75 D |
From 83.00€
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Encequidar
Item number: TGM-T8426-100mg
Description: Encequidar (HM30181A) is a potent and selective P-glycoprotein inhibitor. Target: P-gp. Smiles: COc1cc2CCN(CCc3ccc(cc3)-n3nnc(n3)-c3cc(OC)c(OC)cc3NC(=O)c3cc(=O)c4ccccc4o3)Cc2cc1OC. References: Bauer F, et al. Interaction of HM30181 with P-glycoprotein at the murine blood-brain barrier assessed with...
| Keywords: | HM30181, HM30181A |
| Application: | Targets ATP-binding cassette, subfamily B (MDR/TAP), member 1 [EC:7.6.2.2] (ABCB1, CD243) |
| CAS | 849675-66-7 |
| MW: | 688.73 D |
From 41.00€
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HM-30181 mesylate monohydrate
Item number: TGM-T9173-100mg
Description: HM-30181 mesylate monohydrate is an oral P-glycoprotein (P-gp) inhibitor, used to enhance the oral bioavailability of P-gp substrate drugs. Target: P-gp. Smiles: O=C1C=C(OC=2C=CC=CC12)C(=O)NC3=CC(OC)=C(OC)C=C3C=4N=NN(N4)C5=CC=C(C=C5)CCN6CC7=CC(OC)=C(OC)C=C7CC6.O=S(=O)(O)C.O. References: Cha YJ, Lee H,...
| Application: | Targets ATP-binding cassette, subfamily B (MDR/TAP), member 1 [EC:7.6.2.2] (ABCB1, CD243) |
| CAS | 2097125-58-9 |
| MW: | 802.85 D |
From 62.00€
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ABCB1 Protein, Human, Recombinant (His)
Item number: TGM-TMPH-00981-100ug
Description: ABCB1 Protein, Human, Recombinant (His) is expressed in E. coli.
| Keywords: | Phospholipid transporter ABCB1, CD243, ATP-dependent translocase ABCB1, ATP-binding cassette sub-family B member 1,... |
| MW: | 44.2 kD |
From 193.00€
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Dihydromethysticin
Item number: TGM-TQ0191-10mg
Description: Dihydromethysticin ((+)-Dihydromethysticin) is a kavalactone found in Piper methysticum. It has marked activity on the induction of CYP3A23. Target: P450. Smiles: COC1=CC(=O)O[C@@H](CCc2ccc3OCOc3c2)C1. References: Ma Y, et al. Desmethoxyyangonin and dihydromethysticin are two major pharmacological...
| Keywords: | (+)-Dihydromethysticin |
| Application: | Bioactive kavalactone, P-gp inhibitor |
| CAS | 19902-91-1 |
| MW: | 276.28 D |
From 69.00€
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Biricodar dicitrate
Item number: TGM-T67790-100mg
Description: Biricodar dicitrate (VX-710) is a potent MDR inhibitor with no anticancer activity and can be used to study prostate cancer. Target: NF-kappaB, AChR. Smiles: OC(CC(C(O)=O)(O)CC(O)=O)=O.O=C(C1=CC(OC)=C(C(OC)=C1)OC)C(N2[C@@H](CCCC2)C(OC(CCCC3=CN=CC=C3)CCCC4=CN=CC=C4)=O)=O.OC(CC(C(O)=O)(O)CC(O)=O)=O....
| Keywords: | VX 710, VX 710-3 |
| Application: | Targets ATP-binding cassette, subfamily B (MDR/TAP), member 1 [EC:7.6.2.2] (ABCB1, CD243) |
| CAS | 174254-13-8 |
| MW: | 987.95 D |
From 507.00€
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ONT-093
Item number: TGM-T63338-10mg
Description: ONT-093, a potent inhibitor of the P-glycoprotein pump, has significant potential for investigating cancer diseases. Target: Others. Smiles: N(C(C)C)C1=CC=C(C2=C(N=C(N2)C3=CC=C(/C=C/COCC)C=C3)C4=CC=C(NC(C)C)C=C4)C=C1
| Application: | P-glycoprotein pump inhibitor |
| CAS | 216227-54-2 |
| MW: | 494.67 D |
From 228.00€
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Tariquidar
Item number: TGM-T6287-100mg
Description: Tariquidar (XR9576)(Kd=5.1 nM) is a specific and effective non-competitive inhibitor of P-glycoprotein. It can reverse drug resistance in MDR cell Lines. Target: P-gp. Smiles: COc1cc2CCN(CCc3ccc(NC(=O)c4cc(OC)c(OC)cc4NC(=O)c4cnc5ccccc5c4)cc3)Cc2cc1OC. References: Martin C, et al. Br J Pharmacol, 1999,...
| Keywords: | XR9576 |
| Application: | Targets ATP-binding cassette, subfamily B (MDR/TAP), member 1 [EC:7.6.2.2] (ABCB1, CD243) |
| CAS | 206873-63-4 |
| MW: | 646.73 D |
From 45.00€
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Rhodamine 123
Item number: TGM-T16743-5mg
Description: Rhodamine 123 is a fluorescent dye (lambdaex=503 nm, lambdaem=527 nm). Target: Others. Smiles: COC(C1=CC=CC=C1C2=C3C=CC(N)=CC3=[O+]C4=C2C=CC(N)=C4)=O.[Cl-]. References: M. Huang, et al. Mitochondrial Inner Membrane Electrophysiology Assessed by Rhodamine-123 Transport and Fluorescence. Ann Biomed Eng....
| Keywords: | RH-123, R-22420 |
| Application: | Membrane-permeable cationic dye, P-glycoprotein substrate, mitochondrial stain |
| CAS | 62669-70-9 |
| MW: | 380.83 D |
From 47.00€
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Human MDR-1 Protein, hFc Tag
Item number: DIM-PME100589.10
Recombinant Human MDR-1 with C-terminal human Fc tag. MDR-1(Phe72-Arg113) (Lys213-Thr215) (Thr318-Gln330) (Gly960-Asp973) hFc(Glu99-Ala330), Protein function: Translocates drugs and phospholipids across the membrane (PubMed:8898203, PubMed:2897240, PubMed:9038218). Catalyzes the flop of phospholipids from the...
| Keywords: | ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1 |
| Expressed in: | Human cells |
| Origin: | human |
| CAS | 12 |
| MW: | 34.2 kD |
From 101.00€
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Human MDR-1 (72-113) Protein, hFc Tag
Item number: DIM-PME100601.10
Recombinant Human MDR-1(Phe72-Arg113) with C-terminal human Fc tag. MDR-1(Phe72-Arg113) hFc(Glu99-Ala330), Protein function: Translocates drugs and phospholipids across the membrane (PubMed:8898203, PubMed:2897240, PubMed:9038218). Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of...
| Keywords: | ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1 |
| Expressed in: | Human cells |
| Origin: | human |
| CAS | 12 |
| MW: | 30.9 kD |
From 95.00€
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MDR-1 (human) full length protein-synthetic nanodisc
Item number: DIM-FLP100029.10
Discover a breakthrough in membrane protein research and drug development with DIMA Biotech's Synthetic Nanodiscs. Traditional methods struggle with challenges in obtaining water-soluble and bioactive forms of multi-transmembrane proteins. Our innovative polymer-based Nanodisc platform offers a game-changing...
| Keywords: | MDR1, CD243, EC=7.6.2.2, P-glycoprotein 1, Phospholipid transporter ABCB1, Multidrug resistance protein 1, ATP-dependent... |
| Application: | Full length transmembrane protein, FA, ELISA, screening, immunization, cell-based assays, crystallization |
| Expressed in: | Human cells |
| Origin: | human |
| MW: | 141.5 kD |
From 1,260.00€
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