60 products were found matching "K05410"!

Description: GSK8612 is a highly selective and potent inhibitor of Tank-binding Kinase-1 (TBK1, pIC50: 6.8). Target: IkappaB/IKK. Smiles: Cc1nn(CC(F)(F)F)cc1Nc1ncc(Br)c(NCc2ccc(cc2)S(N)(=O)=O)n1. References: Thomson DW, et al. Discovery of GSK8612, a Highly Selective and Potent TBK1 Inhibitor. ACS Med Chem Lett....

Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 590-729aa. Protein Length: Partial. Tag Info: C-terminal 6xHis-tagged. Target Protein Sequence: LYYHATKAMT HFTDECVKKY EAFLNKSEEW IRKMLHLRKQ LLSLTNQCFD IEEEVSKYQE YTNELQETLP QKMFTASSGI KHTMTPIYPS SNTLVEMTLG MKKLKEEMEG VVKELAENNH ILERFGSLTM DGGLRNVDCL....

MRT67307 is a kinase inhibitor that has been shown to inhibit TBK1, MARK1-4, IKKepsilon, and NUAK1 (IC50 values are 19, 27-52, 160, and 230 nM, respectively), the salt-inducible kinases (SIKs, IC50s = 250, 67, and 430 nM for SIK1, SIK2, and SIK3, respectively) and ULK1 and ULK2 (IC50s = 45 and 38 nM, respectively)....

Soluble in DMSO or dimethylformamide. Antiallergic. Anti-inflammatory. Antagonizes the angiogenic and mitogenic activity of FGF-1 through S100A13. Inhibits FGF-1 release. Binds to HSP90. Inhibits C-terminal chaperone activity. Induces an increase in nonsense-containing mRNAs amount in treated cells, leading to...

Recombinant human TBK1, full length, with N-terminal GST-tag, expressed in Sf9 insect cells via a baculovirus expression system.

Protein function: Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents. Following activation of toll-like receptors by viral or bacterial components, associates with TRAF3 and TANK and phosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as...

Protein function: Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents. Following activation of toll-like receptors by viral or bacterial components, associates with TRAF3 and TANK and phosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as...

TANK-binding kinase 1 (TBK1) is a non-canonical inhibitor of NF-kappaB kinase (IKK) that has an essential role in regulating inflammatory responses to pathogens. Following activation of toll-like receptors by viral DNA, TBK1 interacts with various partners such as STING, MAVS, and TANK to phosphorylate and activate...

Anti-TBK1 Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with Anti-TBK1 from Human, Mouse, cow,dog and rat based on 100% homology with the immunizing sequence. Cross-reactivity with Anti-TBK1 from other sources has not been determined. Protein function:...

0.5mg/ml if reconstituted with 0.2ml sterile DI water. Serine/threonine-protein kinase TANK-binding kinase 1 or NF-kappa-B-activating kinase is an enzyme that in humans is encoded by the TBK1 gene. The gene was assigned to human chromosome 12q14.2. Serine/threonine kinases plays an essential role in regulating...

0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide. Additional name(s) for this target protein: TANK-binding kinase 1, NAK, NF-kB-activating kinase Protein function: Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents. Following...