97 products were found matching "K05404"!
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Telratolimod
Item number: TGM-T17032-100mg
Description: Telratolimod (MEDI9197) is a toll-like receptors 7/8 agonist. It has an antitumor activity. Target: TLR. Smiles: CCCCCCCCCC CCCCCCCC(=O)NCCCCOn1c(CCCC)nc2c(N)nc3ccccc3c12. References: Zhao BG, et al. Combination therapy targeting toll like receptors 7, 8 and 9 eliminates large established tumors. J...
| Keywords: | 3M-052, MEDI9197 |
| Application: | TLR7 / TLR8 agonist |
| CAS | 1359993-59-1 |
| MW: | 593.89 D |
From 171.00€
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PF-4878691
Item number: TGM-T16506-100mg
Description: PF-4878691 (3M-852A) is a potent and selective Toll-like receptor 7 agonist, designed to dissociate its antiviral and inflammatory activities. Target: TLR. Smiles: CCc1nc2c(N)nc3ccccc3c2n1CCCCNS(C)(=O)=O. References: Fidock MD, et al. The innate immune response, clinical outcomes, and ex vivo HCV...
| Keywords: | 3M-852A |
| Application: | TLR7 agonist |
| CAS | 532959-63-0 |
| MW: | 361.46 D |
From 40.00€
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Gardiquimod
Item number: TGM-T15371-10mg
Description: Gardiquimod could inhibit HIV-1 infection of macrophages and activated peripheral blood mononuclear cells. Gardiquimod is an imidazoquinoline analog and is a TLR7/8 agonist. When used at concentrations below 10 µM, Gardiquimod specifically activates TLR7. Target: TLR, HIV Protease. Smiles:...
| Application: | TLR7 ligand |
| CAS | 1020412-43-4 |
| MW: | 313.4 D |
From 31.00€
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CL097
Item number: TGM-T38423-100mg
Description: CL097 is an effective agonist of TLR7 and TLR8. CL097 induces pro-inflammatory cytokines in macrophages and NADPH oxidase priming, thereby increasing the fMLF-stimulated ROS production. Target: Reactive Oxygen Species, TLR. Smiles: CCOCc1nc2c([nH]1)c(N)nc1ccccc21. References: Karama Makni-Maalej, et...
| Keywords: | CL097 |
| Application: | TLR7 / TLR8 dual agonist |
| CAS | 1026249-18-2 |
| MW: | 242.28 D |
From 57.00€
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Guretolimod
Item number: TGM-T38973-5mg
Description: Guretolimod is a Toll-like receptor 7 (TLR7) agonist. Target: Others. Smiles: CCC[C@@H](CCO)Nc1nc(N)nc(C)c1Cc1ccc(CN(CC(O)=O)CC(F)(F)F)cc1OC. References: Hori, Seiji, et, al.Preparation of carboxylic acid compounds as TLR-7 agonists.WO2013172479A1
| Application: | Targets toll-like receptor 7 (TLR7) |
| CAS | 1488364-57-3 |
| MW: | 513.562 D |
951.00€
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TLR7 agonist 2
Item number: TGM-T4258-100mg
Description: TLR7 agonist 2 (TLR7-IN-1) is a specific and effective Toll-like Receptor 7 (TLR7) agonist (LEC=0.4 µM). Target: TLR. Smiles: Cc1cc(COc2nc(N)nc3ccn(Cc4ccccn4)c23)no1. References: McGowan DC, et al. Identification and Optimization of Pyrrolo[3,2-d]pyrimidine Toll-like Receptor 7 (TLR7) Selective Agonists...
| Keywords: | TLR7-agonist-1, TLR7-IN-1 |
| Application: | Toll-like receptor 7 agonist |
| CAS | 1642857-69-9 |
| MW: | 336.35 D |
From 155.00€
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TLR7/8 agonist 1 dihydrochloride
Item number: TGM-T5561-100mg
Description: TLR7/8 agonist 1 dihydrochloride (TLR7/8 agonist-5d) is a TLR7/8 agonist which shows prominent immunostimulatory activities. Target: TLR. Smiles: Cl.Cl.CCCCc1nc2c(N)nc3ccccc3c2n1Cc1ccc(CN)cc1. References: Shukla NM, et al. Syntheses of fluorescent imidazoquinoline conjugates as probes of Toll-like...
| Keywords: | TLR7/8 agonist-5d |
| Application: | Dual toll-like receptor 7/8 agonist |
| CAS | 1620278-72-9 |
| MW: | 432.39 D |
From 67.00€
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Resiquimod
Item number: TGM-T6964-100mg
Description: Resiquimod (R848) is a Toll-like receptor 7/8 (TLR7/TLR8) agonist that induces cytokine upregulation. Resiquimod is an immunomodulator with antitumor and antiviral activity. Target: HCV Protease, TLR. Smiles: CCOCc1nc2c(N)nc3ccccc3c2n1CC(C)(C)O. References: Hemmi H, et al. Nat Immunol. 2002, 3(2),...
| Keywords: | S28463, R848 |
| Application: | TLR7 ligand |
| CAS | 144875-48-9 |
| MW: | 314.38 D |
From 31.00€
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SM-324405
Item number: TGM-T7860-100mg
Description: SM-324405 is an agonist of TLR7. Target: TLR. Smiles: CCCCOc1nc(N)c2[nH]c(=O)n(Cc3cccc(CC(=O)OC)c3)c2n1. References: Kurimoto A, Hashimoto K, Nakamura T.Synthesis and biological evaluation of 8-oxoadenine derivatives as toll-like receptor 7 agonists introducing the antedrug concept[J].J Med Chem. 2010...
| Keywords: | SM 324405 |
| Application: | TLR7 agonist |
| CAS | 677773-91-0 |
| MW: | 385.42 D |
From 52.00€
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Enpatoran
Item number: TGM-T9570-100mg
Description: Enpatoran is an inhibitor of TLR7(IC50 = 11.1 nM) and TLR8(IC50 = 24.1 nM). Enpatoran was found to be inactive against TLR3, TLR4, and TLR9 in vitro and in vivo. Target: TLR. Smiles: N[C@@H]1C[C@@H](CN(C1)c1ccc(C#N)c2ncccc12)C(F)(F)F. References: Jaromir Vlach, et al. Discovery of M5049: A Novel...
| Application: | Targets toll-like receptor 7 (TLR7) |
| CAS | 2101938-42-3 |
| MW: | 320.31 D |
From 119.00€
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1V209
Item number: TGM-T8316-100mg
Description: 1V209 (TLR7 agonist T7) is a Toll-like receptor 7 (TLR7) agonist known for its anti-tumor properties. Target: TLR. Smiles: COCCOc1nc(N)c2[nH]c(=O)n(Cc3ccc(cc3)C(O)=O)c2n1. References: Gold Nanoparticles Coimmobilized with Small Molecule Toll-Like Receptor 7 Ligand and alpha-Mannose as Adjuvants[J]....
| Keywords: | TLR7 agonist T7 |
| Application: | Benzoic-acid modified purine, TLR7 agonist precursor |
| CAS | 1062444-54-5 |
| MW: | 359.34 D |
From 33.00€
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TLR7 Protein, Human, Recombinant (His & Myc)
Item number: TGM-TMPH-02211-100ug
Description: Endosomal receptor that plays a key role in innate and adaptive immunity. Controls host immune response against pathogens through recognition of uridine-containing single strand RNAs (ssRNAs) of viral origin or guanosine analogs. Upon binding to agonists, undergoes dimerization that brings TIR domains...
| Keywords: | TLR7, Toll-like receptor 7 |
| MW: | 29.5 kD |
From 278.00€
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