148 products were found matching "K05119"!
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ALK (human), recombinant protein
Item number: ABS-PP-428.20
| Keywords: | ALK tyrosine kinase receptor, Anaplastic lymphoma kinase, CD antigen CD246, Recombinant Human ALK Protein |
| Expressed in: | E.coli |
| Origin: | human |
| MW: | 10 kD |
From 90.00€
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ALK-IN-1
Item number: TGM-T3059-100mg
Description: ALK-IN-1 (AP26113) is a potent ALK inhibitor with IC50 of 0.62 nM in a cell-free assay, demonstrated ability overcome Crizotinib resistance mediated by a L1196M mutation. Phase 2. Target: ALK, EGFR, IGF-1R. Smiles: N(C1=C(P(C)(C)=O)C=CC=C1)C2=NC(NC3=C(OC)C=C(C=C3)N4CCC(N(C)C)CC4)=NC=C2Cl. References:...
| Keywords: | AP26113, Brigatinib, AP26113-analog |
| Application: | ALK inhibitor |
| CAS | 1197958-12-5 |
| MW: | 529.01 D |
From 42.00€
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X-376
Item number: TGM-T3550-100mg
Description: X-376 (Ensartinib) is an orally available small molecule inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) with potential antineoplastic activity. Upon oral administration, X-396 binds to and inhibits ALK kinase, ALK fusion proteins, and ALK point mutation variants. Inhibition...
| Keywords: | X-396, Ensartinib |
| Application: | ALK inhibitor |
| CAS | 1365267-27-1 |
| MW: | 547.41 D |
From 31.00€
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Brigatinib
Item number: TGM-T3621-100mg
Description: Brigatinib (AP-26113) is a highly potent and selective inhibitor of ALK. Target: FLT, IGF-1R, EGFR, ROS, ALK. Smiles: COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2P(C)(C)=O)n1)N1CCC(CC1)N1CCN(C)CC1. References: Wei-Sheng Huang, et al. J Med Chem, 2016, 59(10):4948-4964.
| Keywords: | AP-26113 |
| Application: | Targets anaplastic lymphoma kinase [EC:2.7.10.1] (ALK, CD246) |
| CAS | 1197953-54-0 |
| MW: | 584.09 D |
From 31.00€
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ALK inhibitor 2
Item number: TGM-T3041-100mg
Description: ALK inhibitor 2 is a new-type and selective inhibitor for the ALK kinase. Target: ALK, FAK. Smiles: CNS(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(cc2OC)N2CCN(C)CC2)ncc1Cl. References: A Dose Finding Study With Oral LDK378 in Patients With Tumors Characterized by Genetic Abnormalities in Anaplastic Lymphoma Kinase...
| Application: | ALK inhibitor |
| CAS | 761438-38-4 |
| MW: | 518.03 D |
From 117.00€
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CEP-37440
Item number: TGM-T2655-1mg
Description: CEP-37440 is an effective and specific Dual FAK/ALK inhibitor with IC50s of 120 nM(ALK cellular in 75% human plasma) and 2.3 nM (FAK). Target: FAK, ALK. Smiles: CNC(=O)c1ccccc1Nc1nc(Nc2ccc3C[C@@H](CCCc3c2OC)N2CCN(CCO)CC2)ncc1Cl. References: Iragavarapu C, et al. J Hematol Oncol. 2015 Feb 27,8(1):17.
| Keywords: | CEP37440 |
| Application: | FAK1 & ALK inhibitor |
| CAS | 1391712-60-9 |
| MW: | 580.12 D |
From 31.00€
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Ensartinib
Item number: TGM-T37585-100mg
Description: Ensartinib (X-396) is a potent dual ALK/MET inhibitor with IC50 values of <0.4 nM for ALK and 0.74 nM for MET. Target: Others. Smiles: C(=O)(N1C[C@@H](C)N[C@@H](C)C1)C2=CC=C(NC(=O)C3=CC(O[C@H](C)C4=C(Cl)C(F)=CC=C4Cl)=C(N)N=N3)C=C2. References: Lovly CM, et al. Insights into ALK-driven cancers revealed...
| Application: | Targets anaplastic lymphoma kinase [EC:2.7.10.1] (ALK, CD246) |
| CAS | 1370651-20-9 |
| MW: | 561.44 D |
From 1,820.00€
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HG-14-10-04
Item number: TGM-T4015-100mg
Description: HG-14-10-04 is a potent and specific ALK (anaplastic lymphoma kinase) inhibitor. Target: ALK. Smiles: COc1cc(ccc1Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12)N1CCC(CC1)N1CCN(C)CC1. References: U.S. Pat. Appl. Publ. (2012), US 20120028924 A1
| Application: | ALK inhibitor |
| CAS | 1356962-34-9 |
| MW: | 532.08 D |
From 55.00€
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Alectinib hydrochloride
Item number: TGM-T8387-100mg
Description: Alectinib hydrochloride (RO5424802 Hydrochloride) is a selective, and orally available inhibitor of ALK( IC50 : 1.9 nM). Target: ALK. Smiles: Cl.CCc1cc2C(=O)c3c([nH]c4cc(ccc34)C#N)C(C)(C)c2cc1N1CCC(CC1)N1CCOCC1. References: Sakamoto H, et al. CH5424802, a selective ALK inhibitor capable of blocking the...
| Keywords: | CH5424802 (Hydrochloride), RO5424802 (Hydrochloride), AF-802 (Hydrochloride) |
| Application: | Antineoplastic, Anaplastic lymphoma kinase (ALK) inhibitor |
| CAS | 1256589-74-8 |
| MW: | 519.08 D |
From 38.00€
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ALK Protein, Mouse, Recombinant (hFc)
Item number: TGM-TMPK-00927-100ug
Description: Anaplastic lymphoma kinase (ALK) is mostly known for its oncogenic role in several human cancers. Recent evidences clearly indicate new roles of ALK and its genetic aberrations (e.g. gene rearrangements and mutations) in immune evasion, innate and cell-mediated immunity. New ALK-related immunotherapy...
| Keywords: | Anaplastic lymphoma kinase, ALK tyrosine kinase receptor, CD246 |
| MW: | 101.11 kD |
From 392.00€
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Ceritinib
Item number: TGM-T1791-100mg
Description: Ceritinib (LDK378) is an ALK tyrosine kinase inhibitor (IC50=200 pM) with selective, ATP-competitive, and oral activity. Ceritinib also inhibits IGF-1R, InsR, and STK22D (IC50=8/7/23 nM). Ceritinib has antitumor activity. Target: IGF-1R, Serine Protease, ALK. Smiles:...
| Keywords: | LDK378 |
| Application: | Targets anaplastic lymphoma kinase [EC:2.7.10.1] (ALK, CD246) |
| CAS | 1032900-25-6 |
| MW: | 558.14 D |
From 45.00€
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CEP-28122
Item number: TGM-T2612-10mg
Description: CEP-28122 is a highly potent and selective, orally active ALK inhibitor. Target: ALK. Smiles: N([C@@H]1[C@@]2(C[C@]([C@@H]1C(N)=O)(C=C2)[H])[H])C3=NC(NC=4C(OC)=C5C(=CC4)CC[C@@H](CC5)N6CCOCC6)=NC=C3Cl. References: Abate F, et al. Leukemia. 2015 Jun,29(6):1390-401.
| Application: | ALK inhibitor |
| CAS | 1022958-60-6 |
| MW: | 539.07 D |
From 49.00€
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