454 products were found matching "K05091"!
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ISCK03
Item number: TGM-T3452-100mg
Description: ISCK03 is a selective SCF/c-Kit inhibitor. Target: c-Kit. Smiles: CC(C)(C)c1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)-n1ccnc1. References: Na YJ, et al. [4-t-butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide (ISCK03) inhibits SCF/c-kit signaling in 501mel human melanoma cells and abolishes melanin production in...
| Application: | Cell-permeable inhibitor of SCF-mediated c-kit activation |
| CAS | 945526-43-2 |
| MW: | 355.45 D |
From 33.00€
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Olverembatinib
Item number: TGM-T3071-100mg
Description: Olverembatinib (GZD 824) is an orally bioavailable Bcr-Abl inhibitor for Bcr-Abl(WT, IC50: 0.34 nM) and Bcr-Abl(T315I, IC50: 0.68 nM). Target: Bcr-Abl. Smiles: CN1CCN(Cc2ccc(NC(=O)c3ccc(C)c(c3)C#Cc3cnc4[nH]ncc4c3)cc2C(F)(F)F)CC1. References: Ren X, et al. J Med Chem. 2013, 56(3), 879-894.
| Keywords: | GZD 824 |
| Application: | Targets abelson tyrosine-protein kinase 1 [EC:2.7.10.2] (ABL1) |
| CAS | 1257628-77-5 |
| MW: | 532.56 D |
From 31.00€
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Multi-kinase inhibitor 1
Item number: TGM-T4191-100mg
Description: Multi-kinase inhibitor 1 (Multi-kinase inhibitor I) is a Multi-kinase inhibitor. Target: c-Kit, Others, Bcr-Abl, PDGFR. Smiles: N(C1=CC(C2=CC=C(C(NCCO)=O)C=C2)=NC=N1)C3=CC=C(OC(F)(F)F)C=C3. References: Chang Hsu Y, et al. Discovery of BPR1K871, a quinazoline based, multi-kinase inhibitor for the...
| Keywords: | Multi-kinase inhibitor I |
| Application: | Multi-kinase inhibitor |
| CAS | 778274-97-8 |
| MW: | 418.37 D |
From 33.00€
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AZD3229
Item number: TGM-T5409-100mg
Description: AZD3229 is a potent pan-KIT mutant inhibitor for the treatment of gastrointestinal stromal tumors. It demonstrates potent single-digit nM growth inhibition across a broad cell panel. Target: c-Kit. Smiles: COCCOc1cc(F)c2c(Nc3ccc(NC(=O)Cn4cc(nn4)C(C)C)cc3)ncnc2c1. References: Kettle JG, et al. Discovery...
| Application: | c-Kit-driven cell proliferation inhibitor |
| CAS | 2248003-60-1 |
| MW: | 479.51 D |
From 61.00€
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Toceranib Phosphate
Item number: TGM-T7394-100mg
Description: Toceranib Phosphate (SU11654 phosphate), is a selective inhibitor of the tyrosine kinase activity of several members of the split kinase RTK family, including Flk-1/KDR, PDGFR. Target: Tyrosinase, PDGFR, VEGFR, c-Kit. Smiles: OP(O)(O)=O.Cc1[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c(C)c1C(=O)NCCN1CCCC1....
| Keywords: | SU11654 phosphate, PHA 291639 phosphate |
| Application: | Targets proto-oncogene tyrosine-protein kinase Kit [EC:2.7.10.1] (KIT, SCFR, CD117) |
| CAS | 874819-74-6 |
| MW: | 494.45 D |
From 41.00€
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BLU-263
Item number: TGM-T9295-100mg
Description: BLU-263 is an investigational, potent, and selective oral small molecule inhibitor of KIT with sub-nanomolar potency against D816V-mutant KIT. Target: c-Kit. Smiles: C[C@](N)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(CCO)c1
| Application: | Targets proto-oncogene tyrosine-protein kinase Kit [EC:2.7.10.1] (KIT, SCFR, CD117) |
| CAS | 2505078-08-8 |
| MW: | 528.58 D |
From 98.00€
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HM43239
Item number: TGM-T9428-100mg
Description: HM43239 is an orally active and selective FLT3 inhibitor with IC 50 s of 1.1 nM, 1.8 nM and 1.0 nM for FLT3 WT, FLT3 internal tandem duplication (ITD) and FLT3 D835Y kinases, respectively. HM43239 directly inhibits the kinase activity of FLT3 as a reversible Type I inhibitor and effectively modulates...
| Keywords: | Tuspetinib |
| Application: | Targets fms-related tyrosine kinase 3 [EC:2.7.10.1] (FLT3, FLK2, CD135) |
| CAS | 2294874-49-8 |
| MW: | 501.07 D |
From 63.00€
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CD117 Protein, Human, Recombinant (hFc)
Item number: TGM-TMPJ-00402-10ug
Description: C-Kit/SCF R is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). c-Kit contains 5 Ig-like C2-type (immunoglobulin-like) domains and 1 protein kinase domain. It belongs to the protein kinase superfamily and CSF-1/PDGF receptor subfamily. SCF R expression...
| Keywords: | SCFR, KIT, CD117, p145 c-kit, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, Piebald trait protein, PBT,... |
| MW: | 140 kD |
From 63.00€
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CD117 Protein, Mouse, Recombinant (His)
Item number: TGM-TMPK-00777-100ug
Description: The c-kit proto-oncogen (CD 117) has been shown to be present in several cell types including normal and neoplastic hemopoietic cells. Among normal BM cells, CD117 expression has been found in about half of the CD34 precursors including progenitors committed to the erythroid, granulo-monocytic, and...
| Keywords: | SCFR, KIT, CD117, c-kit, ckit, PBT |
| MW: | 56.63 kD |
From 477.00€
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CD117 Protein, Human, Recombinant (His & Avi), Biotinylated
Item number: TGM-TMPK-00805-100ug
Description: The c-kit proto-oncogen (CD 117) has been shown to be present in several cell types including normal and neoplastic hemopoietic cells. Among normal BM cells, CD117 expression has been found in about half of the CD34 precursors including progenitors committed to the erythroid, granulo-monocytic, and...
| Keywords: | EC 2.7.10.1, c-kit, SCFR, KIT, ckit, PBT, CD117, EC 2.7.10 |
| MW: | 58.60 kD |
From 798.00€
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c-Kit Protein, Human, Recombinant (His & Avi), Biotinylated
Item number: TGM-TMPY-06656-100ug
Description: c-Kit Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 58.50 kDa and the accession number is P10721-2.
| Keywords: | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, PBT, C-Kit, SCFR, CD117 |
| MW: | 58.50 kD |
From 587.00€
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c-Kit Protein, Human, Recombinant (His)
Item number: TGM-TMPY-01935-100ug
Description: c-Kit Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 56.7 kDa and the accession number is P10721-2.
| Keywords: | PBT, C-Kit, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, SCFR, CD117 |
| MW: | 56.7 kD |
From 378.00€
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