208 products were found matching "K05090"!
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AZD7507
Item number: TGM-T14380-100mg
Description: AZD7507 is a CSF-1R inhibitor with an IC50 of 32 nM. AZD7507 has antitumor activity. Target: HER, CSF-1R, Sodium Channel. Smiles: COc1cc2nnc(C(N)=O)c(Nc3ccc(C)cc3F)c2cc1N1CCN(CCO)CC1. References: Scott DA, et al. Mitigation of cardiovascular toxicity in a series of CSF-1R inhibitors, and the...
| Application: | FMS inhibitor |
| CAS | 1041852-85-0 |
| MW: | 454.5 D |
From 82.00€
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Edicotinib
Item number: TGM-T15199-100mg
Description: Edicotinib (JNJ-527) is a brain penetrant and orally active inhibitor of the colony-stimulating factor-1 receptor (IC50: 3.2 nM). It shows less inhibitory effects on KIT and FLT3 (IC50: 20 nM and 190 nM). It has the potential for Alzheimer's disease and rheumatoid arthritis treatment. Target: FLT,...
| Keywords: | JNJ-527, JNJ-40346527 |
| Application: | Targets macrophage colony-stimulating factor 1 receptor [EC:2.7.10.1] (CSF1R, FMS, CD115) |
| CAS | 1142363-52-7 |
| MW: | 461.6 D |
From 63.00€
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JNJ-28312141
Item number: TGM-T21330-25mg
Description: JNJ-28312141 is an orally active CSF1R inhibitor and a FLT3 inhibitor. JNJ-28312141 is a new agent with potential therapeutic activity in acute myeloid leukemia and in settings where CSF-1-dependent macrophages and osteoclasts contribute to tumor growth and skeletal events. Target: Others. Smiles:...
| Keywords: | JNJ 28312141, JNJ28312141 |
| Application: | CSF1R / FMS inhibitor |
| CAS | 885692-52-4 |
| MW: | 460.57 D |
From 1,491.00€
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ARRY-382
Item number: TGM-T35333-100mg
Description: ARRY-382 is a highly selective oral inhibitor of CSF-1R with an IC50 of 9 nM. Target: CSF-1R. Smiles: N(C(=O)C=1N2C(=NC1)C=C(OCCN3CCN(C)CC3)C=C2)C4=C5C(=NN(CC=6N=C(C)C=CC6)C5=CC=C4)C7CC7. References: David K Edwards V, et al. Oncotarget . 2018 May 15,9(37):24576-24589.
| Application: | CSF1R inhibitor |
| CAS | 1313407-95-2 |
| MW: | 564.68 D |
From 114.00€
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Ki20227
Item number: TGM-T4315-100mg
Description: Ki-20227 is a specific c-Fms tyrosine kinase(CSF1R) inhibitor (IC50: 2 nM). It also has certain inhibitory against VEGFR2(IC50: 12 nM) and c-Kit/PDGFRbeta(IC50: 451/217 nM), respectively. Target: c-Fms, CSF-1R, PDGFR, c-Kit, VEGFR. Smiles: COc1cc(Oc2ccnc3cc(OC)c(OC)cc23)ccc1NC(=O)NC(C)c1nccs1....
| Application: | CSF-1 receptor inhibitor |
| CAS | 623142-96-1 |
| MW: | 480.54 D |
From 39.00€
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Sotuletinib
Item number: TGM-T6119-100mg
Description: Sotuletinib (BLZ945) is an orally active, effective and specific CSF-1R inhibitor (IC50: 1 nM), >1000-fold selective against its closest receptor tyrosine kinase homologs. Target: c-Fms, CSF-1R. Smiles: CNC(=O)c1cc(Oc2ccc3nc(N[C@@H]4CCCC[C@H]4O)sc3c2)ccn1. References: Pyonteck SM, et al. Nat Med. 2013,...
| Keywords: | BLZ945 |
| Application: | Anticancer compound, CSF-1R / c-Fms inhibitor |
| CAS | 953769-46-5 |
| MW: | 398.48 D |
From 32.00€
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cFMS Receptor Inhibitor II
Item number: TGM-T5586-100mg
Description: cFMS Receptor Inhibitor II is a CSF1R kinase (FMS Receptor, colony stimulating factor 1 receptor, Macrophage colony-stimulating factor receptor) inhibitor with an IC50 of 2.8 nM, demonstrating significant selectivity over other kinases. This compound also exhibits notable CSF1R inhibition with an IC50...
| Application: | cFMS (CSF1R) inhibitor |
| CAS | 959860-85-6 |
| MW: | 368.43 D |
From 42.00€
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Pexidartinib hydrochloride
Item number: TGM-T62788-2mg
Description: Pexidartinib hydrochloride (PLX-3397 hydrochloride) is a potent, selective, orally active, ATP-competitive inhibitor of colony-stimulating factor 1 (CSF1R or M-CSFR) (IC50: 20 nM) and c-Kit (IC50: 10 nM), with 10-100 times greater selectivity for these targets compared to FLT3 (IC50: 160 nM), KDR...
| Application: | Targets macrophage colony-stimulating factor 1 receptor [EC:2.7.10.1] (CSF1R, FMS, CD115) |
| CAS | 2040295-03-0 |
| MW: | 454.28 D |
31.00€
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PLX5622
Item number: TGM-T7100-100mg
Description: PLX5622 is a highly selective, brain-penetrant, and orally active CSF1R inhibitor. Target: c-Fms, CSF-1R. Smiles: COc1ncc(F)cc1CNc1ccc(Cc2c[nH]c3ncc(C)cc23)c(F)n1. References: Rosin JM, Vora SR, Kurrasch DM.Depletion of embryonic microglia using the CSF1R inhibitor PLX5622 has adverse sex-specific...
| Keywords: | PLX-5622 |
| Application: | CSF1R inhibitor |
| CAS | 1303420-67-8 |
| MW: | 395.41 D |
From 84.00€
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GTP-14564
Item number: TGM-T71857-100mg
Description: GTP-14564 is a novel tyrosine kinase inhibitor that also inhibits wt-FLT3 and ITD-FLT3. GTP-14564 inhibits the growth of interleukin-3-independent Ba/F1 expressing ITD-FLT3 at 3 µ m, whereas a 30-fold higher concentration of GTP-14564 is required to inhibit the FLT3 ligand-dependent growth (wt-FLT3) of...
| Application: | Class III receptor tyrosine kinase inhibitor |
| CAS | 34823-86-4 |
| MW: | 234.25 D |
From 39.00€
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Emactuzumab
Item number: TGM-T76776-100mg
Description: Emactuzumab(RG 7155) is a monoclonal antibody against colony-stimulating factor-1 receptor targeting tumor-associated macrophages (TAMs) Emactuzumab has antitumor activity and inhibits activation of colony-stimulating factor 1 receptor (CSF1R) Emactuzumab has a high affinity for CSF-1R with a Ki value...
| Keywords: | RG 7155, RO 5509554 |
| Application: | Targets macrophage colony-stimulating factor 1 receptor [EC:2.7.10.1] (CSF1R, FMS, CD115) |
| CAS | 1448221-67-7 |
From 321.00€
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CSF1R Protein (Met1-Glu512), Human, Recombinant (His)
Item number: TGM-TMPY-01037-100ug
Description: CSF1R Protein (Met1-Glu512), Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 56 kDa and the accession number is P07333-1.
| Keywords: | C-FMS, FMS, colony stimulating factor 1 receptor, CSFR, M-CSF-R, MCSF Receptor, HDLS, FIM2, CSF-1R, CD115 |
| MW: | 56 kD |
From 223.00€
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