225 products were found matching "K05089"!

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Dovitinib lactate hydrate
Dovitinib lactate hydrate

Item number: TGM-T6479-100mg

Description: Dovitinib lactate hydrate (TKI258) is the Lactate of Dovitinib, which is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit) with IC50 of 1 nM/2 nM, also potent to class IV (FGFR1/3) and class V (VEGFR1-4) RTKs with IC50 of 8-13 nM, less potent to InsR, EGFR, c-Met, EphA2, Tie2, IGFR1 and...
Keywords: Dovitinib (TKI258) Lactate, Dovitinib Lactate, TKI258
Application: Targets fms-related tyrosine kinase 3 [EC:2.7.10.1] (FLT3, FLK2, CD135)
CAS 915769-50-5
MW: 482.51 D
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Tivozanib hydrochloride hydrate
Tivozanib hydrochloride hydrate

Item number: TGM-T63505-100mg

Description: Tivozanib hydrochloride hydrate (AV-951 hydrochloride hydrate) is an orally active, selective, and potent vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitor that inhibits VEGFR-1, VEGFR-2, and VEGFR-3. Target: VEGFR. Smiles:...
Keywords: KRN951 hydrochloride hydrate, AV-951 hydrochloride hydrate
Application: Targets FMS-like tyrosine kinase 1 [EC:2.7.10.1] (FLT1, VEGFR1)
CAS 682745-41-1
MW: 509.34 D
From 54.00€ *
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CP-673451
CP-673451

Item number: TGM-T6091-100mg

Description: CP-673451 is a specific inhibitor of PDGFRalpha/beta (IC50: 10/1 nM) with antiangiogenic and antitumor activity and the selectivity is higher 450-fold than other angiogenic receptors. Target: PDGFR, VEGFR, c-Kit. Smiles: COCCOc1ccc2n(cnc2c1)-c1ccc2cccc(N3CCC(N)CC3)c2n1. References: Roberts WG, et al....
Application: PDGFRbeta inhibitor
CAS 343787-29-1
MW: 417.5 D
From 45.00€ *
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Dasatinib
Dasatinib

Item number: TGM-T1448-50mg

Description: Dasatinib (BMS-354825) is an orally active, ATP-competitive tyrosine kinase inhibitor that targets Src and Bcr-Abl (Ki=16/30 pM), with antitumor activity, used in the treatment of leukemia and lymphoma. Target: c-Kit, Autophagy, Bcr-Abl, Apoptosis, Src. Smiles:...
Keywords: BMS-354825
Application: Targets abelson tyrosine-protein kinase 1 [EC:2.7.10.2] (ABL1)
CAS 302962-49-8
MW: 488.01 D
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AG 1295
AG 1295

Item number: TGM-T14137-100mg

Description: AG 1295, a selective inhibitor of platelet-derived growth factor receptor (PDGFR) tyrosine-kinase, effectively halts PDGFR autophosphorylation without impacting the autophosphorylation of the EGF receptor[1][2][3][4]. Target: PDGFR. Smiles: Cc1cc2ncc(nc2cc1C)-c1ccccc1. References: Kovalenko M, et al....
Application: PDGF receptor kinase inhibitor
CAS 71897-07-9
MW: 234.3 D
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Vatalanib free base
Vatalanib free base

Item number: TGM-T17219-100mg

Description: Vatalanib is a VEGFR2/KDR inhibitor (IC50: 37 nM). Target: VEGFR. Smiles: ClC1=CC=C(NC2=NN=C(CC3=CC=NC=C3)C3=CC=CC=C23)C=C1
Application: Targets platelet-derived growth factor receptor beta [EC:2.7.10.1] (PDGFRB, CD140B)
CAS 212141-54-3
MW: 346.81 D
From 42.00€ *
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JNJ-10198409
JNJ-10198409

Item number: TGM-T15616-100mg

Description: JNJ- 10198409 is a relatively selective and ATP competitive PDGF-RTK inhibitor (IC50=2 nM). JNJ-10198409 has good activity against PDGFR-beta kinase (IC50=4.2 nM) and PDGFR-alpha kinase (IC50=45 nM). It is a dual-mechanism, antiangiogenic, and tumor cell antiproliferative agent. Target: PDGFR. Smiles:...
Keywords: JNJ-10198409
Application: PDGF-BB inhibitor
CAS 627518-40-5
MW: 325.34 D
From 30.00€ *
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Dasatinib monohydrate
Dasatinib monohydrate

Item number: TGM-T1448L-100mg

Description: Dasatinib monohydrate (BMS-354825 Monohydrate) is an orally bioavailable synthetic small molecule-inhibitor of SRC-family protein-tyrosine kinases. Dasatinib monohydrate binds to and inhibits the growth-promoting activities of these kinases. Apparently, because of its less stringent binding affinity for...
Keywords: BMS-354825 Monohydrate
Application: Targets abelson tyrosine-protein kinase 1 [EC:2.7.10.2] (ABL1)
CAS 863127-77-9
MW: 506.03 D
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Tandutinib
Tandutinib

Item number: TGM-T1667-100mg

Description: Tandutinib (CT53518) (MLN518, CT53518), an effective FLT3 antagonist (IC50: 0.22 µM), can also inhibit c-Kit and PDGFR, 15-20 fold higher potency for FLT3 versus CSF-1R and >100-fold selectivity for the same target versus FGFR, EGFR, and KDR. Target: c-Kit, CSF-1R, Src, FLT, PDGFR, Apoptosis....
Keywords: NSC726292, CT53518, MLN518
Application: Targets fms-related tyrosine kinase 3 [EC:2.7.10.1] (FLT3, FLK2, CD135)
CAS 387867-13-2
MW: 562.7 D
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JI-101
JI-101

Item number: TGM-T3476-100mg

Description: JI-101 (CGI-1842) is an oral multi-kinase inhibitor that targets vascular endothelial growth factor receptor type 2 (VEGFR-2), platelet derived growth factor receptor beta (PDGFR-beta), and ephrin type-B receptor 4 (EphB4). Target: VEGFR, PDGFR, Ephrin Receptor. Smiles:...
Keywords: CGI-1842, JI 101
Application: VEGFR2 inhibitor
CAS 900573-88-8
MW: 466.33 D
From 31.00€ *
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(E/Z)-AG490
(E/Z)-AG490

Item number: TGM-T60624-200mg

Description: (E/Z)-AG490 ((E/Z)-Tyrphostin AG490) is a racemic compound comprising the isomers (E)-AG490 and (Z)-AG490. (E)-AG490 functions as a tyrosine kinase inhibitor, targeting EGFR, Stat-3, and JAK2/3. Target: Others. Smiles: C(=C(C(NCC1=CC=CC=C1)=O)C#N)C2=CC(O)=C(O)C=C2
Application: PDGF receptor autophosphorylation inhibitor
CAS 134036-52-5
MW: 294.3 D
1,229.00€ *
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Orantinib
Orantinib

Item number: TGM-T6184-100mg

Description: Orantinib (NSC 702827) , a excellent effective against PDGFR autophosphorylation with Ki of 8 nM, also highly inhibits Flk-1 and FGFR1 trans-phosphorylation. It shows little effect against IGF-1R, Met, Src, Lck, Zap70, Abl and CDK2 and does not suppresses EGFR. Target: Apoptosis, PDGFR, VEGFR, FGFR....
Keywords: SU6668, NSC 702827, TSU-68
Application: Tyrosine kinase inhibitor
CAS 252916-29-3
MW: 310.35 D
From 46.00€ *
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