173 products were found matching "K05087"!
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Anti-IGF1R
Item number: ABS-KC-1335.100
Protein function: Receptor tyrosine kinase which mediates actions of insulin- like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of...
| Keywords: | Anti-Insulin-like growth factor 1 receptor, Anti-Insulin-like growth factor I receptor, Anti-IGF-I receptor, Anti-CD... |
| Host: | Mouse |
| Species reactivity: | human, mouse |
From 232.00€
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Anti-IGF1R
Item number: ABS-KC-1545.100
Protein function: Receptor tyrosine kinase which mediates actions of insulin- like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of...
| Keywords: | Anti-Insulin-like growth factor 1 receptor, Anti-Insulin-like growth factor I receptor, Anti-IGF-I receptor, Anti-CD... |
| Application: | IP |
| Host: | Mouse |
| Species reactivity: | human |
From 206.00€
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BMS-536924
Item number: TGM-T6419-1mg
Description: BMS-536924 (BMS 536924) is an ATP-competitive IGF-1R/IR inhibitor with IC50 of 100 nM/73 nM, modest activity for Mek, Fak, and Lck with very little activity for Akt1, MAPK1/2. Target: Src, IGF-1R, FAK, MEK, Apoptosis. Smiles: Cc1cc(cc2nc([nH]c12)-c1c(NC[C@@H](O)c2cccc(Cl)c2)cc[nH]c1=O)N1CCOCC1....
| Keywords: | CS-0117, HY-10262, BMS 536924, HY-10262 |
| Application: | IGF1R / insulin receptor inhibitor |
| CAS | 468740-43-4 |
| MW: | 479.96 D |
From 34.00€
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IGF-1R inhibitor-2
Item number: TGM-T38502-5mg
Description: IGF-1R inhibitor-2 (example 121) is a compound that inhibits the insulin-like growth factor-1 receptor (IGF-1R), potentially reversing the transformed phenotype of tumor cells and increasing their susceptibility to apoptosis. Target: Others. Smiles:...
| Application: | IGF-1R inhibitor |
| CAS | 1116236-15-7 |
| MW: | 461.501 D |
970.00€
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NT157
Item number: TGM-T4605-100mg
Description: NT157 is a small molecule tyrphostin targeting IRS protein and has the potential to inhibit IGF-1R and STAT3 signaling pathways in TME cancer cells and stromal cells, resulting in decreased cancer cell survival. Target: IGF-1R, STAT. Smiles: C(=C/C(NCC1=CC(O)=C(O)C(O)=C1)=S)\C2=CC(Br)=C(O)C(O)=C2....
| Application: | IGF-1R signaling inhibitor |
| CAS | 1384426-12-3 |
| MW: | 412.26 D |
From 49.00€
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AEW541 HCl
Item number: TGM-T69682-10mg
Description: AEW541, also known as NVP-AEW541, is a novel, potent IGF-IR kinase inhibitor. NVP-AEW541 is capable of distinguishing between the IGF-IR (IC50 = 0.086 microM) and the closely related InsR (IC50 = 2.3 microM) in cells. NVP- AEW541 abrogates IGF-I-mediated survival and colony formation in soft agar at...
| Application: | IGF-1R kinase inhibitor |
| CAS | 2320261-63-8 |
| MW: | 439.56 D |
From 198.00€
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IGF1R/CD221 Protein, Human, Recombinant (His & Avi)
Item number: TGM-TMPK-00455-100ug
Description: The type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase that is frequently overexpressed by tumours, and mediates proliferation and apoptosis protection. IGF signalling also influences hypoxia signalling, protease secretion, tumour cell motility and adhesion, and thus can affect the...
| Keywords: | IGF-1R, IGF-I R, IGF-I receptor, MGC142172, MGC142170, MGC18216, CD221, JTK13, IGFR, IGFIR, IGF1R |
| MW: | 105.8 kD |
From 485.00€
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IGF1R/CD221 Protein, Human, Recombinant (aa 31-932, His &...
Item number: TGM-TMPK-00456-100ug
Description: The type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase that is frequently overexpressed by tumours, and mediates proliferation and apoptosis protection. IGF signalling also influences hypoxia signalling, protease secretion, tumour cell motility and adhesion, and thus can affect the...
| Keywords: | IGF-1R, IGF-I receptor, IGF1R, MGC142170, IGFR, IGFIR, MGC18216, JTK13, IGF-I R, CD221, MGC142172 |
| MW: | 105.8 kD |
From 814.00€
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IGF1R/CD221 Protein, Human, Recombinant (His)
Item number: TGM-TMPY-00834-100ug
Description: IGF1R/CD221 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 81 kDa and the accession number is P08069.
| Keywords: | IGFIR, IGFR, IGF-I R, IGF1 Receptor, JTK13, CD221, insulin-like growth factor 1 receptor |
| MW: | 81 kD |
From 345.00€
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IGF1R/CD221 Protein, Mouse, Recombinant (His)
Item number: TGM-TMPY-06195-100ug
Description: IGF1R/CD221 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 105.2 kDa and the accession number is E9QNX9.
| Keywords: | A330103N21Rik, D930020L01, hyft, insulin-like growth factor 1 receptor, CD221, IGF-1R |
| MW: | 105.2 kD |
From 699.00€
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IGF1R/CD221 Protein, Human, Recombinant (His & GST)
Item number: TGM-TMPY-04360-50ug
Description: IGF1R/CD221 Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 74.6 kDa and the accession number is P08069.
| Keywords: | IGF1 Receptor, insulin-like growth factor 1 receptor, JTK13, IGF-I R, IGFIR, IGFR, CD221 |
| MW: | 74.6 kD |
497.00€
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AZD-3463
Item number: TGM-T1967-100mg
Description: AZD-3463 (ALK/IGF1R inhibitor), an orally bioavailable ALK inhibitor (Ki: 0.75 nM), can inhibit IGF1R with equivalent potency. Target: ALK, Apoptosis, Autophagy, IGF-1R. Smiles: COc1cc(ccc1Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12)N1CCC(N)CC1. References: 104th AACR meeting, 2013, Abst 919.
| Keywords: | ALK/IGF1R inhibitor |
| Application: | ALK inhibitor, IGF1R inhibitor |
| CAS | 1356962-20-3 |
| MW: | 448.95 D |
From 48.00€
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