26 products were found matching "K05038"!

Description: Iclepertin (BI-425809) is an orally active and selective inhibitor of glycine transporter protein 1 (GlyT1).Iclepertin is used for the treatment of central nervous system disorders such as Alzheimer,s disease. Iclepertin is used for central nervous system disorders such as Alzheimer,s disease,...

Description: Sarcosine (Methylglycine) is a competitive inhibitor of the type I glycine transporter (GlyT1) and an N-methyl-D-aspartate receptor (NMDAR) co-agonist. Target: Endogenous Metabolite, GlyT, Others. Smiles: CNCC(O)=O. References: Zhang HX, et al. Neuropharmacology. 57(5-6):551-5.

Description: Oleoyl-L-carnitine, a long-chain acylcarnitine, acts as a selective inhibitor of glycine transporter 2 (GlyT2, IC50 = 340 nM) while demonstrating significantly lesser affinity for GlyT1 (IC50 = >10,000 nM). Elevated plasma levels of this compound have been observed in patients suffering from chronic...

Description: Bitopertin (Paliflutine) (RG1678, RO-4917838) is a potent inhibitor of glycine transporter 1 (GlyT1), with Ki of 8.1 nM for human hGlyT1b and IC50 of 22-25 nM in Chinese hamster ovary cells. Target: GlyT. Smiles: C[C@H](Oc1ccc(cc1C(=O)N1CCN(CC1)c1ncc(cc1F)C(F)(F)F)S(C)(=O)=O)C(F)(F)F. References:...

Description: GlyT1 Inhibitor 1 is a potent and selective GlyT1 inhibitor [IC50: 38 nM for rGlyT1] exhibiting antipsychotic activity. Target: Others. Smiles: CC(C)Oc1ccc(cc1C(=O)N1Cc2cn(nc2C1)-c1ccnc(C)c1)C#N. References: Santora VJ, et al. Design and Synthesis of Novel and Selective Glycine Transporter-1 (GlyT1)...

Description: LY2365109 hydrochloride is a potent and selective GlyT1 inhibitor, with an IC50 of 15.8 nM for glycine uptake in cells over-expressing [hGlyT1a]. Target: GlyT. Smiles: Cl.CN(CCOc1ccc(cc1C(C)(C)C)-c1ccc2OCOc2c1)CC(O)=O. References: Perry KW et al. Neurochemical and behavioral profiling of the selective...

Bitopertin is an inhibitor of glycine transporter 1 (GlyT1, IC50 = 0.03 µM). It is selective for GlyT1 over GlyT2 (IC50 = >30 µM) as well as a panel of 107 receptors, transporters, and enzymes at 10 µM. Bitopertin (0.1 µM) increases long-term potentiation in rat hippocampal CA1 slices. It reverses hyperlocomotion...

Sarcosine is an intermediate in the biosynthesis of glycine from choline. It is a selective inhibitor of glycine transporter 1 (GlyT1) with IC50 values of 91 and greater than 1,000 µM for GlyT1 and GlyT2, respectively, in HEK293 cells expressing the human transporters. Sarcosine levels are increased in prostate...

Oleoyl-D-lysine is an inhibitor of glycine transporter 2a (GlyT2a). It selectively inhibits GlyT2a (IC50 = 48.3 nM) over GlyT1b (IC50 = >3,000 nM) in Xenopus oocytes expressing the human transporters. Oleoyl-D-lysine (30 mg/kg, i.p.) reduces allodynia in a nerve ligation rat model of neuropathic pain.Formal Name:...

The amino acid glycine acts as an inhibitory neurotransmitter in the central nervous system. The protein encoded by this gene is one of two transporters that stop glycine signaling by removing it from the synaptic cleft. Protein function: Terminates the action of glycine by its high affinity sodium- dependent...

The amino acid glycine acts as an inhibitory neurotransmitter in the central nervous system. The protein encoded by this gene is one of two transporters that stop glycine signaling by removing it from the synaptic cleft. Protein function: Terminates the action of glycine by its high affinity sodium- dependent...

ALX 5407 is an inhibitor of glycine transporter 1 (GlyT1, IC50 = 3 nM). It is selective for GlyT1 over GlyT2 (IC50 = >10 µM), as well as over NMDA receptors and the inhibitory glycine receptor at 100 µM. ALX 5407 (10 mg/kg) increases prefrontal cortical levels of glycine in rats. It also reverses MK-801-induced...