44 products were found matching "K05004"!

Description: MINOXIDIL-d10 is a deuterated compound of MINOXIDIL. MINOXIDIL has a CAS number of 38304-91-5. Minoxidil is an orally administered vasodilator with hair growth stimulatory and antihypertensive effects. Smiles: [2H]C1([2H])N(c2cc(N)[n+]([O-])c(N)n2)C([2H])([2H])C([2H])([2H])C([2H])([2H])C1([2H])[2H]

Description: Cromakalim (BRL 34915) is an ATP-dependent K(+) channel opener and a smooth muscle relaxant.Cromakalim has antiepileptic and anticonvulsant activity and may be useful in studies of asthma and disorders associated with vasodilation. Target: Potassium Channel. Smiles:...

Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific...

Host Species: Rabbit. Isotype: IgG. Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antibodies were produced by immunizing rabbits with...

Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: KCNJ11. Antigen Species: Human

Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: KCNJ11. Antigen Species: Human

(±)-Cromakalim is a prototypical activator of the ATP-sensitive potassium channel, SUR2-Kir6, that displays anti-ischemic (EC25 = 8.9 µM) and cardioprotective (IC50 = 0.03 µM) effects in rat hearts. (±)-Cromakalim has also been shown to relax bladder smooth muscle in vitro. It has been used to investigate potassium...

Minoxidil is a pyrimidine derivative that was originally developed as an anti-hypertensive agent and unexpectedly found to stimulate hair growth. Minoxidil directly affects arteriolar smooth muscle to decrease vascular resistance in part by opening ATP-sensitive potassium channels. It can activate cyclooxygenase 1...

Glyburide is a sulfonylurea and an inhibitor of sulfonylurea receptor 1 (SUR1) linked to ATP-sensitive potassium channel Kir6.2 (IC50 = 4.3 nM). It binds to microsomes derived from RINm5F pancreatic beta-cells (Kd = 0.3 nM) and inhibits 86Rb+ efflux from intact RINm5 cells with a half-maximal inhibition (K0.5) value...

Nicorandil is an activator of sulfonylurea receptor 2B (SUR2B) linked to ATP-sensitive potassium channel Kir6.2 (EC50 = ~10 µM) and a nitric oxide (NO) donor. It is selective for SUR2B/Kir6.2 over the SUR2A/Kir6.2 channel (EC50 = >500 µM). Nicorandil activates soluble guanylate cyclase in a cell-free assay and...

Minoxidil-d10 is intended for use as an internal standard for the quantification of minoxidil (Cay-15302) by GC- or LC-MS. Minoxidil is a pyrimidine derivative that was originally developed as an anti-hypertensive agent and unexpectedly found to stimulate hair growth. Minoxidil directly affects arteriolar smooth...

Gliquidone is a second generation sulfonylurea that selectively inhibits ATP-sensitive potassium channel currents (IKATP) in pancreatic beta-cells (IC50s = 0.45, 119.1, and 149.7 µM for HIT-T15 cells, cardiomyocytes, and vascular smooth muscle cells, respectively). It is also a peroxisome proliferator-activated...