15 products were found matching "K04913"!

Description: ML335 is a selective activator of TREK-1 and TREK-2. Target: Potassium Channel. Smiles: CS(=O)(=O)Nc1ccc(cc1)C(=O)NCc1ccc(Cl)cc1Cl. References: Lolicato M, et al. K2P2.1 (TREK-1)-activator complexes reveal a cryptic selectivity filter binding site. Nature. 2017 Jul 20,547(7663):364-368.

Description: Bupivacaine hydrochloride monohydrate is a potent NMDA receptor inhibitor of sodium, L-calcium, and potassium channels.Bupivacaine hydrochloride monohydrate inhibits SCN5A channels and is commonly used in the study of chronic pain. Target: Sodium Channel, Calcium Channel, NMDAR, Potassium Channel....

Description: BL-1249 is a selective and potent non-steroidal potassium channel activator with anti-inflammatory activity that activates K2P2.1 (TREK-1) and K2P10.1 (TREK-2). Target: Potassium Channel. Smiles: C1CCc2c(C1)cccc2Nc1ccccc1-c1nnn[nH]1. References: Pope L, et al. Protein and Chemical Determinants of...

Organism: Homo sapiens (Human). Source: Yeast. Expression Region: 1-143aa. Protein Length: Partial. Tag Info: N-terminal 6xHis-tagged. Target Protein Sequence: MLPSASRERP GYRAGVAAPD LLDPKSAAQN SKPRLSFSTK PTVLASRVES DTTINVMKWK TVSTIFLVVV LYLIIGATVF KALEQPHEIS QRTTIVIQKQ TFISQHSCVN STELDELIQQ IVAAINAGII PLGNTSNQIS...

BL 1249 is an activator of mechanosensitive two-pore domain potassium channels (K2P). It selectively induces currents in Xenopus oocytes expressing K2P2.1/TREK-1 or K2P10.1/TREK-2 over Xenopus oocytes expressing K2P4.1/TRAAK, K2P3.1/TASK1, K2P3.2/TASK2, K2P3.3/TASK3, K2P18.1/TRESK, K2P13.1/THIK1, or K2P1.1/TWIK-1 at...

ML-335 is an activator of the two-pore domain potassium channels K2P2.1/TREK1 and K2P10.1/TREK2 (EC50s = 14.3 and 5.2 µM, respectively, in Xenopus oocytes). It is selective for K2P2.1/TREK1 and K2P10.1/TREK2 channels over K2P4.1/TRAAK channels. ML-335 activates K2P2.1/TREK1 by binding to the C-type gate, which is...

C3001a is an activator of the two-pore domain potassium channels K2P2.1/TREK1 and K2P10.1/TREK2. It increases current amplitude in HEK293T cells expressing K2P2.1/TREK1 or K2P10.1/TREK2 (EC50s = 12.81 and 11.31 µM, respectively, for the human channels). C3001a is selective for K2P2.1/TREK1 and K2P10.1/TREK2 over a...

Spadin is an inhibitor of the two-pore domain potassium channel K2P2.1/TREK1 (Ki = 10 nM in homogenates from COS-7 cells expressing K2P2.1/TREK1) that corresponds to amino acids 12-28 of human sortilin, also known as the neurotensin-3 receptor (NTS3). It also binds to sortilin in C13NJ microglial cells (Ki = 8 nM)....

PE 22-28 is a peptide inhibitor of the two-pore domain potassium channel K2P2.1/TREK1 (IC50 = 0.1 nM in HEK293 cells expressing the human channel) and a fragment of spadin (Cay-36762). It is selective for K2P2.1/TREK1 over K2P10.1 /TREK2, K2P13.1/TRAAK, K2P18.1/TRESK, and K2P3.1/TASK1 in HEK293 cells expressing the...

Primers are provided as a 40 µl solution containing both primers at a final concentration of 50 µM in 10 mM Tris-HCl (pH 7.5), 0.1 mM EDTA. Dilute with water as needed prior to use. This amount is sufficient for 1000 x 20µl PCR reactions assuming a final primer concentration of 0.1 µM. Add cDNA template....

Primers are provided as a 40 µl solution containing both primers at a final concentration of 50 µM in 10 mM Tris-HCl (pH 7.5), 0.1 mM EDTA. Dilute with water as needed prior to use. This amount is sufficient for 1000 x 20µl PCR reactions assuming a final primer concentration of 0.1 µM. Add cDNA template....

Primers are provided as a 40 µl solution containing both primers at a final concentration of 50 µM in 10 mM Tris-HCl (pH 7.5), 0.1 mM EDTA. Dilute with water as needed prior to use. This amount is sufficient for 1000 x 20µl PCR reactions assuming a final primer concentration of 0.1 µM. Add cDNA template....