27 products were found matching "K04857"!

Description: Pinaverium bromide is an calcium channel blocker with Antispasmodic and effectively relieves pain, diarrhea and intestinal discomfort. Target: Calcium Channel. Smiles: COc1cc(Br)c(C[N+]2(CCOCCC3CCC4CC3C4(C)C)CCOCC2)cc1OC.[Br-]. References: Action of Pinaverium Bromide, a Calcium-Antagonist, on...

Nifedipine is a dihydropyridine L-type calcium channel blocker that reduces the amplitude of spontaneous contractions in isolated rabbit ileum when used at a concentration of 1 µM. Nifedipine (1 µM) reduces TGF-beta-induced calcium oscillations in human fibroblasts and prevents impairment of lung function in a mouse...

Bepridil is a dihydropyridine that has anti-anginal and anti-arrhythmic actions by blocking calcium channels in heart and smooth muscle. It is recognized as a non-selective channel blocker, altering myocardial Ca2+, Na+, and K+ currents. For example, it blocks voltage-gated Ca2+ (Cav3.2) and K+ (hERG and KCNQ4)...

Benidipine is an orally bioavailable blocker of L-, T-, and N-type calcium channels. In guinea pig ventricular cells benidipine has an IC50 of 2.7 nM for calcium currents, determined using whole cell voltage clamp electrophysiology. It prevents oxidative stress dose-dependently in vitro, decreases blood pressure in...

Almost white crystalline powder. A calcium channel antagonist with potent antioxidant activity. It inhibits doxorubicin-induced myocyte apoptosis by supressing the mitochondrial apoptotic pathway.It has been found to inhibit hyperplasia and hypertrophy in mesangial cells.

Lercanidipine is a dihydropyridine L-type calcium channel blocker. It binds to rat brain and heart homogenates (Kis = 0.24-0.3 and 0.22 nM, respectively, in radioligand binding assays) and inhibits potassium-induced contraction of isolated rat aorta (IC50 = 1.3 nM). Lercanidipine reduces diastolic blood pressure...

Nilvadipine is a dihydropyridine L-type calcium channel blocker. It is selective for L-type over N-, P/Q-, and R-type calcium channels at 10 µM. Nilvadipine (10 mg/kg per day, p.o.) inhibits increases in systolic blood pressure induced by chronic intravenous infusion of the peptide vasoconstrictor endothelin in...

Nemadipine A is an L-type calcium channel blocker that induces morphological and growth defects in wild-type C. elegans and those with hypoexpression of egl-19, which encodes the only L-type calcium channel alpha1-subunit in the C. elegans genome. It also inhibits L-type calcium channels in chick ciliary neurons....

Clevidipine is an inhibitor of L-type calcium channels (IC50s = 7.1 and 78.8 nM at -40 and -80 mV, respectively, in isolated guinea pig cardiomyocytes). It preferentially inhibits L-type calcium channels in isolated rat portal vein over rat left ventricle (IC50s = 427 and 20,417 nM, respectively). Clevidipine...

Lacidipine is a dihydropyridine L-type calcium channel blocker. It induces relaxation of isolated rat aorta and inhibits calcium-induced contraction of rabbit ear artery (pA2 = 9.4). It also induces relaxation of calcium-induced contractions in isolated rat colon and bladder and guinea pig trachea (IC50s = 6.7, 6,...

Carboxyamidotriazole is an orally bioavailable, non-selective calcium channel blocker. It blocks L- and T-type calcium channels in GH3 rat pituitary cancer cells (IC50s = 0.5 and 1.5 µg/ml, respectively). It also inhibits calcium influx stimulated by the acetylcholine receptor agonist carbachol (carbamoylcholine,...

Efonidipine is an inhibitor of L- and T-type voltage-gated calcium channels (Cavs). It inhibits Cav1.2a (IC50 = 1.8 nM for the hamster channel), an L-type Cav, and Cav3.2 (IC50 = 350 nM for the human channel), a T-type Cav. It also inhibits L- and T-type calcium channels and fetal bovine serum-induced hypertrophy in...