37 products were found matching "K04855"!

Description: ABT-639 is a potent and selective T-type calcium channel blocker. Target: Calcium Channel. Smiles: [H][C@]12CCCN1CCN(C2)C(=O)c1cc(c(F)cc1Cl)S(=O)(=O)Nc1ccccc1F. References: Jarvis MF, et al. Biochem Pharmacol. 2014 Jun 15,89(4):536-44.

Description: (2R/S)-6-PNG (6-Prenylnaringenin) is a novel natural histone deacetylase inhibitor with anticancer and antitumor activity, and it blocks T-type calcium channels to reduce neuropathic and visceral pain in mice. Target: HDAC, Calcium Channel. Smiles: CC(C)=CCc1c(O)cc2OC(CC(=O)c2c1O)c1ccc(O)cc1....

Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific...

Host Species: Rabbit. Isotype: IgG. Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by...

Aranidipine is an antagonist of voltage-gated calcium channel Cav3.2. It inhibits inward currents in Xenopus oocytes expressing human Cav3.2 channels when used at a concentration of 10 µM. Aranidipine (10 mg/kg) decreases mean blood pressure and increases heart rate in spontaneously hypertensive rats (SHRs). It...

Mibefradil is a general calcium channel blocker that shows modest selectivity for T-type channels over L-type channels (IC50 = 2.7 and 18.6 µM, respectively). It is a potent vasodilator, increasing coronary artery flow with an EC50 value of 54 nM. Mibefradil has minimal negative inotropic effects, supporting its use...

Ethosuximide is an anticonvulsant. It increases glucose, fructose-1,6-bisphosphate, and pyruvate levels in rat brain when administered at a dose of 200 mg/kg. Ethosuximide (400 mg/kg) reduces the severity of audiogenic seizures in a rat model of barbiturate withdrawal-induced convulsions. It also inhibits tonic...

Flunarizine is a calcium antagonist that acts as a potent dilator of peripheral vessels without having calcium-blocking actions in the heart. It reduces calcium fluxes in vascular smooth muscle by blocking both voltage-dependent calcium channels and receptor-operated channels. Flunarizine also acts as a dopamine D2...

(±)-6-Prenylnaringenin ((±)-6-PN) is a flavonoid that has been found in the hop plant, H. lupulus, and has diverse biological activities. It inhibits the T-type voltage-gated calcium (Cav) channel Cav3.2 and high-voltage-activated calcium currents in whole-cell patch-clamp assays using HEK293 cells (IC50s = 0.912...

Anti-CAV3.2 Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with CAV3.2 from Human, Rat, and Mouse based on 100% homology with the immunizing sequence. No cross-reactivity against Cav1.3. Cross-reactivity with CAV3.2 from other sources has not been determined....

Anti-CACNA1H antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. CACNA1H antibody is human, mouse and rat reactive. Multiple isoforms of CACNA1H are known to exist. Protein function: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable...

Penfluridol is a first generation typical antipsychotic that binds to dopamine receptors (IC50 = 5.6 nM). It binds to dopamine D4 receptors and also to serotonin (5-HT) receptors (Kis = 31 and 63.1 nM, respectively). Penfluridol (1.25 and 2.5 mg/kg) inhibits stereotypic behavior induced by apomorphine (Cay-16094) in...