34 products were found matching "K04836"!

Phenytoin is an anticonvulsant agent and active metabolite of fosphenytoin (Cay-23889). Phenytoin is formed from fosphenytoin by tissue phosphatases. It inhibits neuronal voltage-gated sodium channels in a voltage-dependent manner. Phenytoin reduces the neuronal firing frequency and decreases the amplitude of...

Description: ICA-121431 (2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl) is a nanomolar potent small molecule Nav1.7 channel inhibitor with IC50 of 19 nM for rat Nav1.7, with little or no activity against human Nav1.5 or Nav1.7 channels. Target: Sodium Channel. Smiles: O=C(Nc1ccc(cc1)S(=O)(=O)Nc1nccs1)C(c1ccccc1)c1ccccc1....

Description: LacosaMide-d3 is a deuterated compound of LacosaMide. LacosaMide has a CAS number of 175481-36-4. Lacosamide is a functionalized amino acids. Lacosamide modulates sodium channels in a novel manner: It selectively enhances sodium channel slow inactivation with no effects on fast inactivation Lacosamide...

Levobupivacaine-d9 is intended for use as an internal standard for the quantification of levobupivacaine (Cay-31596) by GC- or LC-MS. Levobupivacaine is a sodium channel blocker and local anesthetic, as well as the levorotary stereoisomer of bupivacaine (Cay-16618). It inhibits cardiac sodium channel currents (INa)...

Propafenone is a class I antiarrhythmic agent. It inhibits calcium currents (ICa) in isolated guinea pig ventricular myocytes (IC50 = 5 µM), as well as ATP-sensitive potassium currents (IKATP) in isolated rabbit atrial and ventricular monocytes (IC50s = 1.26 and 4.94 µM, respectively). Propafenone also blocks sodium...

10,11-dihydro-10-hydroxy Carbamazepine is an antiepileptic agent and active metabolite of the prodrug oxcarbazepine (Cay-17340). It is a racemic mixture of (R)- and (S)-10,11-dihydro-10-hydroxy carbamazepine. (S)-10,11-dihydro-10-hydroxy Carbamazepine protects against seizures induced by maximal electroshock (MES)...

Lennox-Gastaut syndrome (LGS) is a severe pediatric epilepsy syndrome characterized by multiple seizure types. Rufinamide is an anticonvulsant. It inhibits the activation of voltage-gated sodium channel 1.1 (Nav1.1) when used at a concentration of 100 µM. Rufinamide inhibits Nav1.1, but not Nav1.2, Nav1.3, and...

Oxcarbazepine is a prodrug form of the antiepileptic compound 10,11-dihydro-10-hydroxy carbamazepine (Cay-18467). It inhibits high-frequency repetitive firing of rat spinal cord neurons when used at a concentration of 1 µM. Oxcarbazepine protects against electroshock-induced tonic hindlimb extension (ED50 = 10-20...

Disopyramide is a sodium channel blocker that, in rabbit ventricular myocytes, binds and dissociates from open channels more quickly than from resting channels. It is a class Ia antiarrhythmic agent that delays conduction through the AV node and ventricles of the dog heart both in vivo (3 and 5 mg/kg) and in vitro...

Eslicarbazepine acetate is a sodium channel blocker (IC50 = 138 nM in a radioligand binding assay). It inhibits sodium uptake in a dose-dependent manner in rat cortical synaptosomes at concentrations ranging from 30-300 µM. In vivo, oral and i.p. administration of eslicarbazepine acetate is protective against...

ICA 121431 is a voltage-gated sodium channel (Nav) blocker that selectively blocks Nav1.1 and Nav1.3 over Nav1.4, and Nav1.5-1.8 channels (IC50s = 10,000 nM, respectively). It induces a concentration-dependent hyperpolarizing shift in voltage dependence of inactivation of Nav1.3 channels at a concentration 1 µM but...

Flecainide is an inhibitor of cardiac late sodium current (INa, IC50 = 3.4 µM) and delayed-rectifier potassium current (IKr, IC50 = 1.5 µM). Formulations containing flecainide have been used in the treatment of arrhythmias and sodium-dependent calcium overload associated with myocardial ischemia and heart...