17 products were found matching "K04815"!

(±)-Nicotine is the racemic mixture of the dominant alkaloid found in tobacco plants. It acts as an agonist at neuronal nicotinic acetylcholine receptors (nAChRs, Kis = 481 and 11.1 nM for alpha3beta4 and alpha4beta2 subtypes, respectively) and possesses addictive and teratogenic properties. (-)-(S)-Nicotine is...

Description: SIB-1553A hydrochloride is an orally available, selective nicotinic acetylcholine receptor agonist and a selective neuronal nAChR ligand.SIB-1553A hydrochloride enhances cognition and may be useful in the study of Alzheimer's disease and cognitive impairment. Target: AChR. Smiles:...

Mecamylamine is a noncompetitive nicotinic acetylcholine receptor antagonist with preferential activity at the alpha3beta4 subtype (IC50 = 90-640 nM) compared to alpha4beta2, alpha3beta2, and alpha7 subtypes (IC50 range from 1-7 µM). Mecamylamine is widely used as a broad-spectrum antagonist of neuronal nicotinic...

SIB 1553A is an agonist of nicotinic acetylcholine receptors (nAChRs) that displays selectivity for beta4 subunit-containing receptors. Formulations containing SIB 1553A improve attentional function and performance in spatial and non-spatial working memory tasks in animals.Formal Name:...

Light yellow powder/crystals. Soluble in toluene. Pyridine-like alkaloid. Nicotine agonist. Potent agonist at alpha3beta4 and alpha7 nicotinic acetylcholine receptors and partial agonist at alpha4beta2 nicotinic acetylcholine receptors. Shows analgesic, antihypertensive and inotropic activities. Used for smoking...

Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels in the central and peripheral nervous system. SR 16584 is an antagonist of the alpha3beta4 nAChR subtype (IC50 = 10.2 µM). It shows selective binding of the alpha3beta4 subtype compared to the alpha4beta2 and alpha7 subtypes (Ki values of...

ABT-594 is a potent agonist of neuronal alpha4beta2 subunit-containing nicotinic acetylcholine receptors (nAChRs, Ki = 37 pM in a radioligand binding assay). It is selective for neuronal nAChRs over neuromuscular alpha1beta1deltagamma subunit-containing nAChRs (Ki = 10,000 nM), alpha1B-, alpha2B-, and alpha2C-...

Adiphenine is an anticholinergic agent. It is an antagonist of nicotinic acetylcholine receptors (nAChRs, IC50s = 1.8, 3.7, and 6.3 µM for the alpha3beta4, alpha4beta2, and alpha4beta4 subunit-containing receptors, respectively), as well as muscarinic acetylcholine receptors (Ki = 0.44 µM). Adiphenine inhibits...

alpha-Conotoxin AuIB is a conotoxin that has been found in C. aulicus and has receptor antagonist and analgesic activity. It is a peptide antagonist of alpha3beta4 subunit-containing nicotinic acetylcholine receptors (nAChRs, IC50 = 0.75 µM). It is greater than 100-fold selective for alpha3beta4 subunit-containing...

This gene is found within a conserved gene cluster and encodes one of the beta subunits of the nicotinic acetylcholine receptor (nAChRs) superfamily which form ligand-gated ion channels with a central pore that forms a cation channel. Neuronal nAChRs are pentameric structures that can be either homomeric or...

This gene is found within a conserved gene cluster and encodes one of the beta subunits of the nicotinic acetylcholine receptor (nAChRs) superfamily which form ligand-gated ion channels with a central pore that forms a cation channel. Neuronal nAChRs are pentameric structures that can be either homomeric or...

Description: alpha3beta4 nAChR antagonist. Target: Others. Smiles: O=C1N(C=2C(C1)=CC=CC2)[C@@H]3C[C@@]4(N(C)[C@](C3)(CCC4)[H])[H]. References: Solt L A, Kumar N, He Y, et al. Identification of a selective RORgamma ligand that suppresses Th17 cells and stimulates T regulatory cells[J]. ACS chemical biology, 2012,...