52 products were found matching "K04809"!
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Methyllycaconitine citrate
Item number: TGM-T12017-5mg
Description: Methyllycaconitine citrate (MLA) is an alpha7 neuronal nicotinic acetylcholine receptor (alpha7nAChR) antagonist that crosses the blood-brain barrier. Target: AChR. Smiles:...
| Keywords: | MLA |
| Application: | nAChR (CHRNA7) antagonist |
| CAS | 351344-10-0 |
| MW: | 874.92 D |
146.00€
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(-)-(S)-B-973B
Item number: TGM-T17300-10mg
Description: (-)-(S)-B-973B is an effective allosteric agonist and positive allosteric modulator of alpha7 nAChR. Target: AChR. Smiles: C[C@H](NC(=O)CCc1ccc(F)c(F)c1)c1cncc(n1)N1CCN(CC1)c1ccccn1. References: Garai S, et al. B-973, a Novel alpha7 nAChR Ago-PAM: Racemic and Asymmetric Synthesis, Electrophysiological...
| Application: | alpha7 nAChR ago-PAM (allosteric agonist / positive allosteric modulator) |
| CAS | 2244989-34-0 |
| MW: | 452.5 D |
From 45.00€
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Bradanicline HCl
Item number: TGM-T30574-100mg
Description: Bradanicline(TC-5619) is the agonist of Alpha-7 Nicotinic Receptor. Target: Others. Smiles: C([C@H]1[C@H](NC(=O)C2=CC=3C(O2)=CC=CC3)C4CCN1CC4)C=5C=CC=NC5.Cl. References: Walling D, Marder SR, Kane J, Fleischhacker WW, Keefe RS, Hosford DA, Dvergsten C, Segreti AC, Beaver JS, Toler SM, Jett JE, Dunbar...
| Keywords: | TC 5619-023, TC 5619, TC-5619-023, TC-5619, TC5619-023, TC5619 |
| Application: | Targets nicotinic acetylcholine receptor alpha-7 (CHRNA7) |
| CAS | 1111941-90-2 |
| MW: | 397.9 D |
From 1,491.00€
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PNU-282987 free base
Item number: TGM-T60437-100mg
Description: PNU-282987 (free base) is a potent agonist of alpha7 nicotinic acetylcholine receptor (nAChR) with an EC50 of 154 nM and a functional antagonist of the 5-HT3 receptor with an IC50 of 4541 nM. It can be used for central and peripheral nervous system studies[1]. Target: 5-HT Receptor, AChR. Smiles:...
| Application: | nAChR (CHRNA7) agonist |
| CAS | 711085-63-1 |
| MW: | 264.75 D |
From 50.00€
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Encenicline
Item number: TGM-T7193-100mg
Description: Encenicline (EVP-6124) is a selective alpha7 nicotinic acetylcholine receptor (nAChRs) agonist being developed to treat cognitive impairment in schizophrenia and Alzheimer's disease. Target: AChR. Smiles: Cl.[H][C@]12CCN(CC1)C[C@@H]2NC(=O)c1cc2cccc(Cl)c2s1. References: Prickaerts J, van Goethem NP,...
| Keywords: | EVP-6124 |
| Application: | Targets nicotinic acetylcholine receptor alpha-7 (CHRNA7) |
| CAS | 550999-75-2 |
| MW: | 320.84 D |
From 109.00€
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PNU-120596
Item number: TGM-T6950-100mg
Description: PNU-120596 (NSC-216666) is a positive allosteric modulator of alpha7 nAChR with EC50 of 216 nM. Target: AChR. Smiles: COc1cc(OC)c(NC(=O)Nc2cc(C)on2)cc1Cl. References: Hurst RS, et al, J Neurosci, 2005, 25(17), 4396-4405.
| Keywords: | NSC 216666 |
| Application: | Positive allosteric CHRNA7 modulator |
| CAS | 501925-31-1 |
| MW: | 311.72 D |
From 34.00€
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NS 1738
Item number: TGM-T7884-100mg
Description: NS 1738 (NSC-213859) is a positive allosteric modulator of the alpha7-containing neuronal nicotinic acetylcholine receptors (nAChRs). Target: AChR. Smiles: Oc1ccc(Cl)cc1NC(=O)Nc1cc(ccc1Cl)C(F)(F)F. References: Timmermann D B , Gronlien J H , Kohlhaas K L , et al. An Allosteric Modulator of the ?7...
| Keywords: | NSC 213859 |
| Application: | Positive allosteric nAChR (CHRNA7) modulator |
| CAS | 501684-93-1 |
| MW: | 365.13 D |
From 47.00€
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CCMI
Item number: TGM-T7422-100mg
Description: CCMI (AVL-3288) is a potent and selective modulator of alpha7 nAChR-positive allosteric sites. Target: AChR. Smiles: Cc1cc(on1)C(=C/Nc1ccc(Cl)cc1)\C(=O)Nc1ccc(Cl)cc1. References: Ng H J , Whittemore E R , Tran M B , et al. Nootropic ?7 nicotinic receptor allosteric modulator derived from GABAA receptor...
| Keywords: | AVL-3288 |
| Application: | Alpha7 nAChR positive allosteric modulator |
| CAS | 917837-54-8 |
| MW: | 388.25 D |
From 39.00€
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A-867744
Item number: TGM-TQ0117-100mg
Description: A-867744 is an effective and selective type II positive allosteric modulator of the alpha7 nAChR (EC50: 1.0 µM). Target: Autophagy, AChR. Smiles: CCC(=O)c1cc(-c2ccc(Cl)cc2)n(c1C)-c1ccc(cc1)S(N)(=O)=O. References: Malysz J, et al. In vitro pharmacological characterization of a novel allosteric modulator...
| Application: | Positive allosteric alpha7 nAChR modulator |
| CAS | 1000279-69-5 |
| MW: | 402.89 D |
From 39.00€
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Neuronal acetylcholine receptor subunit alpha-7 (CHRNA7),...
Item number: CSB-EP005393HUa0.1
Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 23-230aa. Protein Length: Partial. Tag Info: N-terminal 6xHis-tagged. Target Protein Sequence: GEFQRKLYKE LVKNYNPLER PVANDSQPLT VYFSLSLLQI MDVDEKNQVL TTNIWLQMSW TDHYLQWNVS EYPGVKTVRF PDGQIWKPDI LLYNSADERF DATFHTNVLV NSSGHCQYLP PGIFKSSCYI DVRWFPFDVQ...
| Keywords: | CHRNA7, NACHRA7, Neuronal acetylcholine receptor subunit alpha-7, Recombinant Human Neuronal acetylcholine receptor... |
| Application: | Activity not tested |
| Expressed in: | E.coli |
| Origin: | human |
| MW: | 30.4 kD |
From 283.00€
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Anti-CHRNA7
Item number: CSB-PA969473.100
Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: CHRNA7. Antigen Species: Human
| Keywords: | Anti-CHRNA7, Anti-NACHRA7, Anti-Neuronal acetylcholine receptor subunit alpha-7, 7nAChR antibody, a7 nicotinic... |
| Application: | ELISA, WB, IHC |
| Host: | Rabbit |
| Species reactivity: | human, mouse, rat |
From 163.00€
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B-973B
Item number: Cay38790-1
B-973B is an allosteric agonist and positive allosteric modulator (ago-PAM) of alpha7 nicotinic acetylcholine receptors (nAChRs). It enhances ACh-induced activation in a two-electrode voltage-clamp assay using Xenopus oocytes expressing the human alpha7 nAChR when used at a concentration of 10 µM. B-973B (10 mg/kg)...
| Keywords: | (-)-(S)-B-973B, 3,4-difluoro-N-[(1S)-1-[6-[4-(2-pyridinyl)-1-piperazinyl]-2-pyrazinyl]ethyl]-benzenepropanamide |
| Application: | alpha7 nAChR ago-PAM (allosteric agonist / positive allosteric modulator) |
| CAS | 2244989-34-0 |
| MW: | 452.5 D |
From 47.00€
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