42 products were found matching "K04806"!

Description: Tebanicline hydrochloride (Ebanicline hydrochloride) , is an effective synthetic nicotinic (non-opioid) analgesic drug. Target: AChR. Smiles: Cl.Clc1ccc(OC[C@H]2CCN2)cn1. References: Donnelly-Roberts DL, et al. ABT-594 [(R)-5-(2-azetidinylmethoxy)-2-chloropyridine]: a novel, orally effective analgesic...

(±)-Nicotine is the racemic mixture of the dominant alkaloid found in tobacco plants. It acts as an agonist at neuronal nicotinic acetylcholine receptors (nAChRs, Kis = 481 and 11.1 nM for alpha3beta4 and alpha4beta2 subtypes, respectively) and possesses addictive and teratogenic properties. (-)-(S)-Nicotine is...

Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: CHRNA4. Antigen Species: Human

Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: CHRNA4. Antigen Species: Human

(±)-Anabasine is an alkaloid that has been found as a minor component in tobacco (Nicotiana). It is a full agonist of nicotinic acetylcholine receptors (nAChRs) that induces depolarization of TE 671 cells endogenously expressing human fetal muscle-type nAChRs (EC50 = 10.1 µM) but not SH-SY5Y cells that primarily...

Varenicline-d4 is intended for use as an internal standard for the quantification of varenicline (Cay-15030) by GC- or LC-MS. Varenicline is a full agonist of alpha7 subunit-containing neuronal nicotinic acetylcholine receptors (nAChRs, EC50 = 18 µM) and a partial agonist of alpha4beta2 subunit-containing nAChRs...

Varenicline is a full agonist of alpha7 subunit-containing neuronal nicotinic acetylcholine receptors (nAChRs, EC50 = 18 µM) and a partial agonist of alpha4beta2 subunit-containing nAChRs (EC50 = 2.3 µM). Formulations containing varenicline have been used as aids in smoking cessation.Formal Name:...

(-)-Nicotine is an alkaloid that has been found in tobacco. It is an agonist at neuronal nicotinic acetylcholine receptors (nAChRs) and binds to alpha3beta4 and alpha4beta2 subunit-containing nAChRs with Ki values of 481 and 11.1 nM, respectively. Chronic exposure to (-)-nicotine results in increased expression of...

(±)-Nicotine-d3 is intended for use as an internal standard for the quantification of (±)-nicotine (Cay-16535) by GC- or LC-MS. (±)-Nicotine is the racemic mixture of the dominant alkaloid found in tobacco plants. It acts as an agonist at neuronal nicotinic acetylcholine receptors (nAChRs, Kis = 481 and 11.1 nM for...

ABT-594 is a potent agonist of neuronal alpha4beta2 subunit-containing nicotinic acetylcholine receptors (nAChRs, Ki = 37 pM in a radioligand binding assay). It is selective for neuronal nAChRs over neuromuscular alpha1beta1deltagamma subunit-containing nAChRs (Ki = 10,000 nM), alpha1B-, alpha2B-, and alpha2C-...

Protein function: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodium ions. [The UniProt Consortium]

0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide. Additional name(s) for this target protein: Cholinergic receptor, nicotinic, alpha 4, BFNC, EBN Protein function: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to...