129 products were found matching "K04718"!
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Opaganib
Item number: AG-CR1-3749-M025
Opaganib is a selective inhibitor of sphingosine kinase 2 (SPHK2, Ki = 9.8 µM), a lipid kinase that catalyzes formation of the lipid signaling molecule sphingosine 1-phosphate (S1P). S1P promotes cancer growth, and proliferation and pathological inflammation, including TNF-alpha signaling and other inflammatory...
| Keywords: | 3-(4-Chlorophenyl)-adamantane-1-carboxylic acid (pyridin-4-ylmethyl)amide, ABC294640, Yeliva |
| Application: | SPHK2 inhibitor |
| CAS | 915385-81-8 |
| MW: | 380.9 D |
From 99.00€
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K145 hydrochloride
Item number: TGM-TQ0138-5mg
Description: K145 hydrochloride is a selective sphk2 inhibitor with substrate competitiveness and oral activity, with IC50 of 4.3 µM and Ki of 6.4 µM. K145 hydrochloride can induce apoptosis and has strong antitumor activity. Target: S1P Receptor, Apoptosis. Smiles: Cl.CCCCOc1ccc(CC\C=C2/SC(=O)N(CCN)C2=O)cc1....
| Application: | SphK2 inhibitor |
| CAS | 1449240-68-9 |
| MW: | 384.92 D |
From 49.00€
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SKI 5C
Item number: TGM-T24803-10mg
Description: SKI 5C is a selective inhibitor of Sphingosine Kinase 1. Target: Others. Smiles: C(OC(C)(C)C)(=O)N1[C@H](C(C#CCCCCCCCCC CCCC)=O)COC1(C)C. References: Li ZH, Tao YF, Xu LX, Zhao H, Li XL, Fang F, Wu Y, Lu J, Li YH, Du WW, Ren JL, Li YP, Xu YY, Feng X, Wang J, He WQ, Pan J. A novel sphingosine kinase 1...
| Keywords: | SKI5C, SKI-5C |
| Application: | SPHK 1 inhibitor |
| CAS | 120005-55-2 |
| MW: | 435.64 D |
From 67.00€
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K6PC-5
Item number: TGM-T27710-100mg
Description: K6PC-5 is a ceramide derivative that acts as an activator of sphingosine kinase 1 (SPHK1), inducing a swift and temporary rise in intracellular calcium levels. With its potential applications in skin diseases associated with abnormal keratinocyte function, as well as in studies on neurodegeneration and...
| Keywords: | K6PC5, K6PC 5 |
| Application: | SPHK1 activator |
| CAS | 756875-51-1 |
| MW: | 343.5 D |
From 34.00€
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SLC5111312 HCl
Item number: TGM-T28803-1mg
Description: SLC5111312 is an inhibitor of SphK1 and SphK2. Target: Others. Smiles: C(=N)(N)N1[C@@H]([C@@H](O)CC1)C2=NC(=NO2)C3=CC4=C(C=C3)C=C(OCCCCC)C=C4.Cl. References: Kharel Y, Morris EA, Congdon MD, Thorpe SB, Tomsig JL, Santos WL, Lynch KR. Sphingosine Kinase 2 Inhibition and Blood Sphingosine 1-Phosphate...
| Keywords: | SLC5111312 hydrochloride, SLC 5111312, SLC-5111312, SLC5111312 |
| Application: | SPHK1 / SPHK2 inhibitor |
| CAS | 1870811-01-0 |
| MW: | 445.94 D |
From 142.00€
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SLM6031434 HCl
Item number: TGM-T28806-10mg
Description: SLM6031434 is selective inhibitor of SphK2. Target: Others. Smiles: C(=N)(N)N1[C@@H](CCC1)C2=NC(=NO2)C3=CC(C(F)(F)F)=C(OCCCCCCCC)C=C3.Cl
| Keywords: | SLM 6031434, SLM6031434, SLM-6031434 |
| Application: | SPHK2 inhibitor |
| CAS | 1897379-34-8 |
| MW: | 489.96 D |
From 128.00€
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MHP
Item number: TGM-T4658-100mg
Description: Methyl caprooyl tyrosinate (MHP) is an activator of sphingosine kinase (SPHK1) and significantly stimulates CAMP mRNA and protein production in KC. Target: S1P Receptor. Smiles: CCCCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)OC. References: Jeong SK, et al. Sphingosine kinase 1 activation enhances epidermal innate...
| Keywords: | Methyl caprooyl tyrosinate |
| Application: | SPHK1 activator |
| CAS | 1104874-94-3 |
| MW: | 293.36 D |
From 40.00€
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SLM6031434 (free base)
Item number: TGM-T70071-10mg
Description: SLM6031434 (free base) is an inhibitor of sphingosine kinase type 2 (SphK2). It consists of pedant 1-guanidino-2-phenyloxadiazolylpyrrolidine group. Target: Others. Smiles: C(=N)(N)N1[C@@H](CCC1)C2=NC(=NO2)C3=CC(C(F)(F)F)=C(OCCCCCCCC)C=C3
| Application: | SPHK2 inhibitor |
| CAS | 1897379-33-7 |
| MW: | 453.5 D |
From 128.00€
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SKI-178
Item number: TGM-T9014-100mg
Description: SKI-178 is a sphingosine kinase 1 (SphK1) inhibitor with IC50 of 0.1-1.8 µM. It induces prolonged mitosis followed by apoptotic cell death through the intrinsic apoptotic cascade. The sustained activation of CDK1 during prolonged mitosis, mediated by SKI-178 leads to the simultaneous phosphorylation of...
| Application: | Sphingosine kinase inhibitor |
| CAS | 1259484-97-3 |
| MW: | 394.42 D |
From 42.00€
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PF-543 hydrochloride
Item number: TGM-T8840-100mg
Description: PF-543 hydrochloride (PF-543) inhibits SphK1 with a K(i) of 3.6 nM, is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2 isoform. Target: Autophagy, S1P Receptor, Apoptosis, LPL Receptor. Smiles: Cl.Cc1cc(CS(=O)(=O)c2ccccc2)cc(OCc2ccc(CN3CCC[C@@H]3CO)cc2)c1....
| Keywords: | PF-543 |
| Application: | Sphingosine kinase 1 inhibitor |
| CAS | 1706522-79-3 |
| MW: | 502.1 D |
From 34.00€
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Sphingosine Kinase 1/SPHK1 Protein, Human, Recombinant...
Item number: TGM-TMPY-04431-50ug
Description: Sphingosine Kinase 1/SPHK1 Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 70.3 kDa and the accession number is Q9NYA1-1.
| Keywords: | SPHK, SPHK1, SPK, sphingosine kinase 1 |
| MW: | 70.3 kD |
497.00€
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Sphingosine Kinase 1/SPHK1 Protein, Human, Recombinant
Item number: TGM-TMPY-04432-50ug
Description: Sphingosine Kinase 1/SPHK1 Protein, Human, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 42.7 kDa and the accession number is Q9NYA1-1.
| Keywords: | SPHK, SPHK1, sphingosine kinase 1, SPK |
| MW: | 42.7 kD |
497.00€
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