46 products were found matching "K04605"!

LY379268 is a potent, brain-permeable, and selective agonist of group II metabotropic glutamate receptors (mGluRs), subtypes mGluR2 and mGluR3. In an assay of second messenger response, LY379268 exhibits EC50 values of 2.69 and 4.48 nM for human mGluR2 and mGluR3, respectively, with at least 80-fold selectivity over...

Description: Talaglumetad hydrochloride is a prodrug of Eglumegad which is the potent and selective agonist of the type II metabotropic glutamate receptor (mGluR2/3) to treat with psychiatric disorders. Target: Others. Smiles: Cl.[H][C@@]12CC[C@@](NC(=O)[C@H](C)N)(C(O)=O)[C@]1([H])[C@H]2C(O)=O

Description: LY2140023 has the potential for schizophrenia.LY2140023 is an orally active prodrug of LY404039. LY404039 is a selective metabotropic glutamate 2/3 receptor agonist. Target: GluR. Smiles: N(C([C@H](CCSC)N)=O)[C@]1(C(O)=O)[C@]2([C@]([C@@H]2C(O)=O)(S(=O)(=O)C1)[H])[H]. References: Lowe S, et al. Effects...

Description: Pomaglumetad methionil is an oral methionine prodrug of the potent specific agonist of mGlu2/3 receptor LY404039. Target: GluR. Smiles: N(C([C@H](CCSC)N)=O)[C@]1(C(O)=O)[C@]2([C@]([C@@H]2C(O)=O)(S(=O)(=O)C1)[H])[H].O. References: Adams DH, et al. A long-term, phase 2, multicenter, randomized,...

Description: Biphenylindanone A is a selective potentiator of human mGluR2 (hmGluR2),and for the treatment of neurological disorders. Target: GluR. Smiles: Cc1c2C(=O)C(Cc2cc(OCc2cccc(c2)-c2ccc(cc2)C(O)=O)c1C)C1CCCC1. References: Rowe BA, et al. Transposition of three amino acids transforms the human metabotropic...

Description: Xanthurenic Acid (8-Hydroxykynurenic acid), a molecule arising from tryptophan metabolism by transamination of 3-hydroxykynurenine, activates mGlu2/3 Metabotropic glutamate receptors (mGlu2 and mGlu3). Target: GluR, Endogenous Metabolite, Apoptosis. Smiles: OC(=O)c1cc(O)c2cccc(O)c2n1. References:...

Description: JNJ-42153605 is a mGlu2 receptor positive allosteric modulator (EC50: 17 nM). Target: GluR. Smiles: FC(F)(F)c1c(ccn2c(CC3CC3)nnc12)N1CCC(CC1)c1ccccc1. References: Cid JM, et al. Discovery of 3-cyclopropylmethyl-7-(4-phenylpiperidin-1-yl)-8-trifluoromethyl[1,2,4]triazolo[4,3-a]pyridine (JNJ-42153605): a...

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The metabotropic glutamate receptor 2 (mGluR2) is a Gi/o-coupled receptor which is expressed on presynaptic nerve terminals and modulates the release of neurotransmitters like glutamate and GABA. Biphenylindanone A (BINA) is a positive allosteric modulator of mGluR2, stimulating the human and rat receptors with EC50...

LY341495 is a potent and selective antagonist of the group II metabotropic glutamate receptors (mGluR), mGluR2 and mGluR3 (IC50s = 21 and 14 nM, respectively, for human isoforms). It less effectively blocks mGluR8 and mGluR7 (IC50s = 173 and 990 nM, respectively) and weakly antagonizes mGluR1, mGluR5, and mGluR4...

LY404039 is a potent agonist of metabotropic glutamate (mGlu) group II receptors mGluR2 and mGluR3 (Kis = 149 and 62 nM, respectively, for recombinant human isoforms). It displays 100-fold selectivity for mGluR2/3 over ionotropic glutamate receptors, glutamate transporters, and several other receptors targeted by...

Xanthurenic acid is formed upon tryptophan degradation by indoleamine 2,3-dioxygenase. It has been shown to be an endogenous Group II metabotropic glutamate receptor (mGluR2 and mGluR3) agonist and is implicated in the pathophysiology of schizophrenia. Xanthurenic acid has also been identified as an inducer of...