132 products were found matching "K04581"!

Mazdutide is a novel long-acting dual glucagon-like peptide-1 (GLP-1) receptor and glucagon receptor (GCGR) agonist. Mazdutide potently activates the GLP-1R signaling pathway to stimulate glucose-dependent insulin secretion through activity at the GCG receptor (GCGR) or the GLP-1R. Mazdutide is a synthetic peptide...

Survodutide is a novel long-acting dual glucagon-like peptide-1 (GLP-1) receptor and glucagon receptor (GCGR) agonist. Survodutide potently activates the GLP-1R signaling pathway to stimulate glucose-dependent insulin secretion through activity at the GCG receptor (GCGR) or the GLP-1R. Survodutide is a synthetic...

GLP-1R modulator L7-028 is a positive allosteric modulator of the glucagon-like peptide 1 receptor (GLP-1R). It enhances GLP-1 binding to GLP-1R (EC50 = 11.01 µM) and cAMP accumulation induced by GLP-1 (7-36) in CHO cells expressing GLP-1R.Formal Name:...

Taspoglutide is an agonist of the glucagon-like peptide 1 receptor (GLP-1R, Ki = 1.1 nM for the human receptor). It induces cAMP accumulation in CHO-K1 cells expressing human GLP-1R (EC50 = 0.06 nM). Taspoglutide (1 mg/animal per week) decreases blood levels of glucose and increases blood levels of insulin in an...

Ecnoglutide is a cAMP-biased peptide glucagon-like peptide 1 receptor (GLP-1R) agonist. It selectively induces cAMP accumulation over beta-arrestin recruitment (EC50s = 0.018 and 1,300 nM, respectively) without inducing GLP-1R receptor internalization (EC50 = >10,000 nM) in cell-based assays using human GLP-1R. In...

VU0453379 is an allosteric agonist and positive allosteric modulator (ago-PAM) of glucagon-like peptide 1 receptor (GLP-1R). It induces calcium mobilization in 9-3-H cells expressing human GLP-1R (EC50 = 1.3 µM) and enhances GLP-1-, exenatide-, or liraglutide-induced calcium mobilization in the same cells (EC50s =...

Description: Exendin-4 (Exenatide) is a glucagon-like peptide-1 receptor (GLP-1) agonist (IC50: 3.22 nM). Exenatide is a 39 amino acid peptide. Compared to GLP-1, exenatide has a longer half-life of 2.4 hours. Target: Glucagon Receptor. Smiles:...

Description: GLP-1R Agonist DMB is an agonist of glucagon-like peptide 1 receptor (GLP-1R, KB = 26.3 nM for the recombinant human receptor). Target: Glucagon Receptor. Smiles: CC(C)(C)Nc1nc2cc(Cl)c(Cl)cc2nc1S(C)(=O)=O. References: Koole, C., Wootten, D., Simms, J., et al. Allosteric ligands of the glucagon-like...

Description: Shanzhiside methylester reduces neuropathic pain by activating spinal GLP-1 receptors and subsequently stimulating microglial beta-endorphin expression via the p38 MAPK signaling. Target: Glucagon Receptor. Smiles:...

Description: LSN3318839 is a potent and orally available glucagon-like peptide-1 receptor (GLP-1R) modulator.LSN3318839 enhances GLP-1R G-protein-coupled signaling and can be used to lower blood glucose. Target: Glucagon Receptor. Smiles:...

Description: Liraglutide (Liraglutida) is a synthetic analog of glucagon-like peptide-1 (GLP-1), an agonist of the GLP-1 receptor. Liraglutide can be used to treat type 2 diabetes and chronic obesity. Target: Glucagon Receptor. Smiles: CCCCCCCCCC...

Description: Survodutide (BI 456906) is a dual agonist of glucagon and glucagon-like peptide 1 (GLP-1) receptors (GLP Receptor) that reduces body weight in HbA1c16 diabetes. Target: Glucagon Receptor. References: Blüher M,et al. Dose-response effects on HbA1c and bodyweight reduction of survodutide, a dual...