308 products were found matching "K04520"!
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Ro 90-7501
Item number: TGM-T16773-100mg
Description: Ro 90-7501 is an amyloid beta42 (Abeta42) protofibrillar and TPR-dependent PP5 inhibitor, a novel radiosensitizer for cervical cancer cells, which inhibits ATM phosphorylation, promotes apoptosis, and induces cell-cycle arrest. Ro 90-7501 also exhibits antiviral activity and potential anticancer...
| Keywords: | RO-90-7501 |
| Application: | Abeta42 fibril assembly inhibitor, TLR3 signaling modulator |
| CAS | 293762-45-5 |
| MW: | 340.38 D |
From 31.00€
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Thioflavin T
Item number: TGM-T17073-1g
Description: Thioflavin T (Basic Yellow 1) is a widely used dye for visualizing and is a cationic Benzothiazole dye that shows enhanced fluorescence upon binding to amyloid in tissue sections. Target: Others. Smiles: [Cl-].CN(C)c1ccc(cc1)-c1sc2cc(C)ccc2[n+]1C. References: Khurana R, et al. Mechanism of thioflavin T...
| Keywords: | Basic Yellow 1 |
| Application: | Fluorescent amyloid fibril probe |
| CAS | 2390-54-7 |
| MW: | 318.86 D |
30.00€
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BMS 299897
Item number: TGM-T14673-10mg
Description: BMS 299897 is a sulfonamide gamma-secretase inhibitor with an IC50 of 7 nM for inhibiting Abeta production in HEK293 cells stably overexpressing amyloid precursor protein (APP). Target: Gamma-secretase, Beta Amyloid. Smiles: C[C@@H](N(c1cc(F)ccc1F)S(=O)(=O)c1ccc(Cl)cc1)c1ccc(F)cc1CCCC(O)=O. References:...
| Application: | Gamma-secretase inhibitor |
| CAS | 290315-45-6 |
| MW: | 511.94 D |
From 52.00€
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RU-505
Item number: TGM-T24743-10mg
Description: RU-505 is an interaction inhibitor of Abeta-fibrinogen that acts by rescuing altered thrombosis and cognitive decline in Alzheimer's disease mice. Target: Others. Smiles: C(C)(C)(C)C1=NN2C(=CC(C(N(CC3=CC=CC=C3)CCN(C)C)=O)=NC2=C1)C4=CC=C(F)C=C4. References: Ahn HJ, Glickman JF, Poon KL, Zamolodchikov D,...
| Keywords: | RU 505, RU505 |
| Application: | Abeta-fibrinogen interaction inhibitor |
| CAS | 1314206-29-5 |
| MW: | 473.58 D |
From 140.00€
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Tabersonine
Item number: TGM-T3246-100mg
Description: Tabersonine (Tabersonin)is a terpene indole alkaloid found in the medicinal plant Catharanthus roseus. Target: Others. Smiles: CC[C@]12CC(C(=O)OC)=C3Nc4ccccc4[C@]33CCN(CC=C1)[C@H]23
| Keywords: | (-)-Tabersonine, Tabersonin |
| Application: | Bioactive indole alkaloid, Abeta42 fibril formation inhibitor |
| CAS | 4429-63-4 |
| MW: | 336.43 D |
From 36.00€
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CRANAD-28
Item number: TGM-T31091-100mg
Description: CRANAD-28 is a blood-brain barrier (BBB) penetrating two-photon imaging probe capable of visualizing amyloid plaques and labeling plaques and cerebral amyloid angiopathy. Target: Others. Smiles: Cc1c(\C=C\C2=CC(\C=C\c3cnn(c3C)-c3ccccc3)=[O+][B-](F)(F)O2)cnn1-c1ccccc1. References: Zhang X, Tian Y, Yuan...
| Keywords: | CRANAD28 |
| Application: | Plaque labelling |
| CAS | 1623747-97-6 |
| MW: | 484.31 D |
From 53.00€
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Gypenoside XVII
Item number: TGM-T3385-100mg
Description: Gypenoside XVII (Gynosaponin S) confers protection against Abeta25-35-induced neurotoxicity through estrogen receptor-dependent activation of PI3K/Akt pathways, activation of Nrf2/ARE/HO-1 and inactivation of GSK-3beta pathways. Target: GSK-3, Estrogen Receptor/ERR, Endogenous Metabolite. Smiles:...
| Keywords: | Gynosaponin S, GP-17 |
| Application: | Bioactive saponin |
| CAS | 80321-69-3 |
| MW: | 947.15 D |
From 41.00€
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NIAD-4
Item number: TGM-T36948-10mg
Description: NIAD-4 is a fluorescent probe that crosses the blood-brain barrier to bind with high affinity to amyloid-beta (Abeta) plaques (Ki = 10 nM). It displays excitation/emission spectra of 475/625 nm, respectively, with the far-red emission occurring upon binding to Abeta. Smiles:...
| Application: | Abeta binding fluorescent probe |
| CAS | 868592-56-7 |
| MW: | 334.42 D |
From 77.00€
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Glycerophosphorylethanolamine (sodium salt)
Item number: TGM-T37531-1mg
Description: Glycerophosphorylethanolamine is an active phosphodiester metabolite of phosphatidylethanolamine.1,2It promotes aggregation of amyloid-beta (1-40) (Abeta40)in vitro, and levels of glycerophosphorylethanolamine are elevated in postmortem brains isolated from patients with Alzheimer's disease. Target:...
| Application: | Phosphatidylethanolamine active metabolite, Abeta40 aggregation promotor |
| CAS | 883288-78-6 |
| MW: | 238.132 D |
580.00€
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Ezeprogind disulfate
Item number: TGM-T37621-100mg
Description: Ezeprogind disulfate is a neurotrophic inducer. Ezeprogind disulfate targets all causes of neurodegeneration including Abeta protein or tau protein. Ezeprogind disulfate can be used for the research of neurological disorders, including progressive supranu. Target: Beta Amyloid. Smiles:...
| Application: | APP proteolysis inhibitor |
| CAS | 1616671-13-6 |
| MW: | 624.81 D |
From 149.00€
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Aftin-4
Item number: TGM-T4364-100mg
Description: Aftin-4, an amyloid forty-two inducer, activates gamma-secretase, promoting the generation of amyloid-beta-1-42 (Abeta1-42) from amyloid-beta protein precursor. Aftin-4(Aftin4) increased Abeta-1-42, but not Abeta-1-40 in mouse hipppocampus, accompanied by learning deficits and mitochondrial...
| Keywords: | Aftin 4, Aftin4 |
| Application: | Roscovitine control |
| CAS | 866893-90-5 |
| MW: | 368.48 D |
From 41.00€
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RO4929097
Item number: TGM-T6274-100mg
Description: RO4929097 (RG-4733), a gamma secretase inhibitor (IC50: 4 nM), inhibits cellular processing of Abeta40 and Notch (EC50: 14/5 nM). Target: Gamma-secretase, Beta Amyloid. Smiles: CC(C)(C(=O)NCC(F)(F)C(F)(F)F)C(=O)N[C@H]1c2ccccc2-c2ccccc2NC1=O. References: Luistro L, et al. Preclinical profile of a potent...
| Keywords: | RG-4733 |
| Application: | Potent gamma-secretase inhibitor |
| CAS | 847925-91-1 |
| MW: | 469.4 D |
From 40.00€
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