614 products were found matching "K04456"!
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3CAI
Item number: TGM-T14034-100mg
Description: 3CAI is a potent and specific AKT1 and AKT2 inhibitor, demonstrating significant inhibition of AKT in an in vitro kinase assay. It suppressed the expression of AKT direct downstream targets (such as mTOR and GSK3beta) and induced growth inhibition and apoptosis in colon cancer cells. Target: Akt....
| Application: | Akt1 / Akt2 inhibitor |
| CAS | 28755-03-5 |
| MW: | 193.63 D |
From 50.00€
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A-443654
Item number: TGM-T14072-100mg
Description: A-443654, a pan-Akt inhibitor, exhibits equal potency against Akt1, Akt2, and Akt3 within cells (Ki=160 pM). Target: MAPK, Casein Kinase, PKC, Src, Akt, FLT, Chk, GSK-3, CDK, ERK, VEGFR, PKA, S6 Kinase. Smiles: C([C@@H](COC=1C=C(C=NC1)C=2C=C3C(=CC2)NN=C3C)N)C=4C=5C(NC4)=CC=CC5. References:...
| Application: | Potent and selective Akt inhibitor |
| CAS | 552325-16-3 |
| MW: | 397.47 D |
From 82.00€
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AKT-I-1
Item number: TGM-T25017-100mg
Description: AKT-I-1 is a selective and reversible inhibitor of Akt1. Target: Akt. Smiles: CN(C)CC(C)(C)CNc1nn2c(nnc2cc1C1CCC1)-c1ccccc1. References: Zhang Q, et al. Autophagy prevention sensitizes AKTi-1/2-induced anti-hepatocellular carcinoma cell activity in vitro and in vivo. Biochem Biophys Res Commun. 2016 Nov...
| Application: | Akt1 inhibitor |
| CAS | 473382-39-7 |
| MW: | 378.51 D |
From 228.00€
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10-DEBC hydrochloride
Item number: TGM-T21778-1mg
Description: 10-DEBC hydrochloride, a selective Akt inhibitor demonstrating an IC50 value of 1.28 µM, is identified as a novel anti-tuberculosis compound [1] [2]. Target: Others. Smiles: Cl.ClC1=CC=C2OC=3C=CC=CC3N(C2=C1)CCCCN(CC)CC
| Application: | Akt phosphorylation inhibitor |
| CAS | 925681-41-0 |
| MW: | 381.34 D |
From 120.00€
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Miransertib
Item number: TGM-T3467-100mg
Description: Miransertib (ARQ-092) is an orally bioavailable, selective, and potent allosteric Akt inhibitor. Target: Akt, Parasite. Smiles: Nc1ncccc1-c1nc2ccc(nc2n1-c1ccc(cc1)C1(N)CCC1)-c1ccccc1. References: Yu Y, et al. PLoS One. 2015, 10(10):e20140479.
| Keywords: | AKT inhibitor 2, ARQ-092 |
| Application: | Targets RAC serine/threonine-protein kinase [EC:2.7.11.1] (AKT) |
| CAS | 1313881-70-7 |
| MW: | 432.52 D |
From 44.00€
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SC66
Item number: TGM-T3132-10mg
Description: SC66 is a AKT inhibitor in HepG2, HA22T/VGH, and PLC/PRF/5 cells (IC50: about 0.75 µg/ml, at 72 h). Target: Apoptosis, Akt. Smiles: O=C1\C(CCC\C1=C/c1ccncc1)=C\c1ccncc1. References: Cusimano A, et al. Oncotarget. 2015 Jan 30,6(3):1707-22.
| Application: | AKT inhibitor |
| CAS | 871361-88-5 |
| MW: | 276.33 D |
From 40.00€
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AKT inhibitor VIII
Item number: TGM-T3346-100mg
Description: AKT inhibitor VIII (AKTi-1/2) is a highly specific inhibitor of Akt1/2, with IC50 values of 58 nM and 210 nM respectively, demonstrating approximately 36-fold greater selectivity for Akt1 over Akt3. Target: Apoptosis, Akt. Smiles: O=c1[nH]c2ccccc2n1C1CCN(Cc2ccc(cc2)-c2nc3cc4[nH]cnc4cc3nc2-c2ccccc2)CC1....
| Keywords: | AKTi-1/2 |
| Application: | Akt1/Akt2 inhibitor |
| CAS | 612847-09-3 |
| MW: | 551.64 D |
From 44.00€
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CAY10567
Item number: TGM-T36086-100mg
Description: CAY10567 has a wide range of applications in life science related research. Target: Others. Smiles: OC(=O)C1=CC=C2N=C(C3=CC=CC=C3)C(=NC2=C1)C1=CC=CC=C1
| Application: | Akt1 translocation inhibitor |
| CAS | 32387-96-5 |
| MW: | 326.35 D |
From 67.00€
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Isobavachalcone
Item number: TGM-T3861-100mg
Description: Isobavachalcone (Corylifolinin) is a chalcone constituent of Angelica keiskei, has potent anti-inflammatory activity, possible can ameliorate neuronal injury in brain diseases associated with inflammation. Target: Autophagy, Apoptosis, Akt, Reactive Oxygen Species, Others. Smiles:...
| Keywords: | Corylifolinin, Isobacachalcone |
| Application: | Akt1 inibitor |
| CAS | 20784-50-3 |
| MW: | 324.37 D |
From 54.00€
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AKT-IN-1
Item number: TGM-T4489-100mg
Description: AKT-IN-1 (AZD-26) is an allosteric AKT inhibitor (IC50: 1.04 µM). Target: Akt. Smiles: NC(=O)c1cnc(-c2ccc(cc2)C2(N)CCC2)c(c1)-c1ccccc1. References: Kettle JG, et al. Diverse heterocyclic scaffolds as allosteric inhibitors of AKT. J Med Chem. 2012 Feb 9,55(3):1261-73.
| Keywords: | AZD26, AZD-26, AZD 26 |
| Application: | AKT inhibitor |
| CAS | 1357158-81-6 |
| MW: | 343.42 D |
From 112.00€
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BAY1125976
Item number: TGM-T7315-100mg
Description: BAY1125976 is an allosteric inhibitor of Akt1 and Akt2 (IC50s of 5.2 and 18 nM, respectively, in a time-resolved FRET assay). Target: Akt. Smiles: NC(=O)c1ccc2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1. References: Politz O , Siegel F , Bärfacker L, et al. BAY 1125976, a selective allosteric AKT1/2...
| Application: | Allosteric Akt1/2 inhibitor |
| CAS | 1402608-02-9 |
| MW: | 383.45 D |
From 33.00€
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Borussertib
Item number: TGM-T8427-100mg
Description: Borussertib is a first-in-class covalent-allosteric inhibitor of protein kinase Akt, with an IC50 of 0.8 nM and a Ki of 2.2 nM for Aktwt. Target: Akt. Smiles: C=CC(=O)Nc1ccc2[nH]c(=O)n(C3CCN(Cc4ccc(cc4)-c4nc5cc[nH]c(=O)c5cc4-c4ccccc4)CC3)c2c1. References: Niklas Uhlenbrock, et al. Structural and...
| Application: | Akt1 / Akt2 inhibitor |
| CAS | 1800070-77-2 |
| MW: | 596.68 D |
From 132.00€
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