221 products were found matching "K04447"!
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JAK2 JH2 Domain (human, recombinant, aa 513-827) -...
Item number: Cay42273-10
JAK2 is a non-receptor tyrosine kinase that has roles in immune signaling. It is composed of N-terminal FERM and SH2 domains, a regulatory JH2 pseudokinase domain, and a C-terminal JH1 kinase domain. It is widely expressed and associates with class I and class II cytokine receptors at the plasma membrane. Activation...
| Keywords: | JAK-2, JAK-2, Janus kinase 2, Janus kinase 2, Tyrosine-protein kinase JAK2 {ECO:0000305}, Tyrosine-protein kinase JAK2... |
| Application: | Active enzyme |
| Expressed in: | Insect cells |
| Origin: | human |
512.00€
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Peficitinib hydrobromide
Item number: TGM-T33905-100mg
Description: Peficitinib hydrobromide is used in the treatment of Psoriasis and Rheumatoid Arthritis. Target: Others. Smiles: Br.[H][C@]12CC3C[C@]([H])(CC(O)(C3)C1)[C@H]2Nc1c(cnc2[nH]ccc12)C(N)=O. References: D'Amico F, Fiorino G, Furfaro F, Allocca M, Danese S. Janus kinase inhibitors for the treatment of...
| Application: | Targets Janus kinase 1 [EC:2.7.10.2] (JAK1) |
| CAS | 1353219-05-2 |
| MW: | 407.312 D |
From 1,638.00€
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TG101209
Item number: TGM-T3065-100mg
Description: TG101209 is a selective JAK2 inhibitor with an IC50 of 6 nM. Target: Autophagy, FLT, Apoptosis, c-RET, JAK. Smiles: CN1CCN(CC1)c1ccc(Nc2ncc(C)c(Nc3cccc(c3)S(=O)(=O)NC(C)(C)C)n2)cc1. References: Pardanani A, et al, Leukemia, 2007, 21(8), 1658-1668.
| Application: | Tyrosine kinase inhibitor |
| CAS | 936091-14-4 |
| MW: | 509.67 D |
From 40.00€
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AT9283
Item number: TGM-T3068-100mg
Description: AT9283 (J-504568) is an effective multi-targeted inhibitor of JAK2(IC50=1.2 nM) and JAK3(IC50=1.1 nM), Aurora A, Aurora B and Abl(T315I). Target: JAK, FLT, Autophagy, Aurora Kinase, Apoptosis, Bcr-Abl. Smiles: O=C(NC1CC1)Nc1c[nH]nc1-c1nc2cc(CN3CCOCC3)ccc2[nH]1. References: Howard S, et al. J Med...
| Keywords: | J-504568 |
| Application: | Broad spectrum kinase inhibitor |
| CAS | 896466-04-9 |
| MW: | 381.43 D |
From 39.00€
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AZD-1480
Item number: TGM-T3069-10mg
Description: AZD1480 is a novel ATP-competitive JAK2 inhibitor (IC50: 0.26 nM), selectivity act against Tyk2 and JAK3, and to a smaller extent against JAK1. AZD1480 has been used in trials studying the treatment of Solid Malignancies, Post-Polycythaemia Vera, Primary Myelofibrosis (PMF), and Essential...
| Application: | JAK2 inhibitor |
| CAS | 935666-88-9 |
| MW: | 348.77 D |
From 52.00€
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XL019
Item number: TGM-T3072-100mg
Description: XL019 is a potent and selective JAK2 inhibitor with IC50 of 2.2 nM, 100 fold selectivity over JAK1. Target: Apoptosis, FLT, PDGFR, JAK. Smiles: O=C(Nc1ccc(cc1)-c1ccnc(Nc2ccc(cc2)N2CCOCC2)n1)[C@@H]1CCCN1. References: Forsyth T, et al. Bioorg Med Chem Lett, 2012, 22(24), 7653-7658.
| Application: | JAK2 inhibitor |
| CAS | 945755-56-6 |
| MW: | 444.53 D |
From 67.00€
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NVP-BSK805
Item number: TGM-T5049-10mg
Description: NVP-BSK805 (BSK 805) is an ATP-competitive JAK2 inhibitor. Target: Tyrosine Kinases, JAK. Smiles: Cl.Cl.Fc1cc(cc(F)c1CN1CCOCC1)-c1cccc2ncc(nc12)-c1cnn(c1)C1CCNCC1. References: Cheon JH, et al. The JAK2 inhibitors CEP-33779 and NVP-BSK805 have high P-gp inhibitory activity and sensitize drug-resistant...
| Keywords: | BSK 805, NVP-BSK805 2HCl |
| Application: | JAK2 inhibitor |
| CAS | 1092499-93-8 |
| MW: | 490.55 D |
From 56.00€
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CEP-33779
Item number: TGM-T6122-100mg
Description: CEP-33779 is a novel and selective inhibitor of JAK2 with an IC50 of 1.8±0.6 nM. Target: JAK. Smiles: CN1CCN(CC1)c1cccc(Nc2nc3c(cccn3n2)-c2ccc(cc2)S(C)(=O)=O)c1. References: Stump KL, et al. Arthritis Res Ther, 2011, 13(2), R68.
| Keywords: | CEP33779 |
| Application: | JAK2 inhibitor |
| CAS | 1257704-57-6 |
| MW: | 462.57 D |
From 38.00€
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AZ960
Item number: TGM-T6309-10mg
Description: AZ960 is an effective ATP competitive JAK2 inhibitor (IC50/Ki: <3 nM and0.45 nM). Target: Parasite, Apoptosis, Virus Protease, JAK. Smiles: C[C@H](Nc1nc(Nc2cc(C)[nH]n2)c(F)cc1C#N)c1ccc(F)cc1. References: Gozgit JM, et al. J Biol Chem. 2008, 283(47), 32334-32343.
| Keywords: | AZ 960 |
| Application: | JAK2 inhibitor |
| CAS | 905586-69-8 |
| MW: | 354.36 D |
From 66.00€
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Tofacitinib
Item number: TGM-T6321-100mg
Description: Tofacitinib (Tasocitinib) is a Janus kinase inhibitor that inhibits JAK3/2/1 (IC50=1/20/112 nM) and is orally active. Tofacitinib is used for the treatment of moderate to severe rheumatoid arthritis. Target: JAK, Apoptosis, ROCK, Src. Smiles: C[C@@H]1CCN(C[C@@H]1N(C)C1=C2C=CNC2=NC=N1)C(=O)CC#N....
| Keywords: | CP-690550, Tasocitinib |
| Application: | Targets Janus kinase 1 [EC:2.7.10.2] (JAK1) |
| CAS | 477600-75-2 |
| MW: | 312.37 D |
From 31.00€
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Momelotinib HCl
Item number: TGM-T70823-100mg
Description: Momelotinib HCl is a JAK1/2 inhibitor, reducing anemia in myelofibrosis (MF) patients. Target: Others. Smiles: Cl.Cl.O=C(NCC#N)c1ccc(cc1)-c1ccnc(Nc2ccc(cc2)N2CCOCC2)n1
| Application: | Targets Janus kinase 1 [EC:2.7.10.2] (JAK1) |
| CAS | 1380317-28-1 |
| MW: | 487.38 D |
From 1,491.00€
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Fedratinib hydrochloride hydrate
Item number: TGM-T9251-100mg
Description: Fedratinib hydrochloride hydrate (SAR 302503 hydrochloride hydrate) is a potent, selective, ATP-competitive and orally active JAK2 inhibitor. Target: Apoptosis, JAK. Smiles: O.Cl.Cl.Cc1cnc(Nc2ccc(OCCN3CCCC3)cc2)nc1Nc1cccc(c1)S(=O)(=O)NC(C)(C)C. References: Wernig G, et al. Efficacy of TG101348, a...
| Keywords: | TG-101348 hydrochloride hydrate, SAR 302503 hydrochloride hydrate |
| Application: | Targets Janus kinase 2 [EC:2.7.10.2] (JAK2) |
| CAS | 1374744-69-0 |
| MW: | 615.61 D |
From 39.00€
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