223 products were found matching "K04447"!

JAK2 is a non-receptor tyrosine kinase that has roles in immune signaling.1,2 It is composed of N-terminal FERM and SH2 domains, a regulatory JH2 pseudokinase domain, and a C-terminal JH1 kinase domain. It is widely expressed and associates with class I and class II cytokine receptors at the plasma membrane.3,4...

JAK2 is a non-receptor tyrosine kinase that has roles in immune signaling.1,2 It is composed of N-terminal FERM and SH2 domains, a regulatory JH2 pseudokinase domain, and a C-terminal JH1 kinase domain. It is widely expressed and associates with class I and class II cytokine receptors at the plasma membrane.3,4...

Protein function: Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with...

Protein function: Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with...

JAK2 is a non-receptor tyrosine kinase that has roles in immune signaling. It is composed of N-terminal FERM and SH2 domains, a regulatory JH2 pseudokinase domain, and a C-terminal JH1 kinase domain. It is widely expressed and associates with class I and class II cytokine receptors at the plasma membrane. Activation...

Janus-associated kinases (JAKs) are cytoplasmic tyrosine kinases that are required for activating the signaling of certain cytokines and growth factor receptors. A JAK2 gene fusion mutation, JAK2V617F, that causes unchecked activation of various growth factors and cytokines, has been linked to myeloproliferative...

White to off-white solid. Soluble in DMSO or ethanol. Insoluble in water. Antineoplastic, anti-inflammatory and immunomodulating agent, Orally bioavailable potent ATP mimetic that inhibits both JAK1 and JAK2 with IC50 values of 2.7 and 4.5nM, respectively and is less selective for JAK3 (IC50 = 322nM), Affects DC...

Description: Ruxolitinib (INCB018424) is a JAK1/2 inhibitor (IC50=3.3/2.8 nM) that is potent and selective. Rixolitinib exhibits antitumor activity and induces autophagy and apoptosis. Target: Mitophagy, Autophagy, Apoptosis, Tyrosine Kinases, JAK. Smiles: N#CC[C@H](C1CCCC1)n1cc(cn1)-c1ncnc2[nH]ccc12....

Description: Momelotinib (LM-1149) is an orally bioavailable small-molecule inhibitor of Janus kinases 1 and 2 (JAK1/2) with IC50 of 11 nM/18 nM. JAK1/2 inhibitor CYT387 competes with JAK1/2 for ATP binding, which may result in inhibition of JAK1/2 activation, inhibition of the JAK-STAT signaling pathway, and so the...

Description: Nezulcitinib (TD-0903) is an inhaled, lung-selective pan-Janus kinase (JAK) inhibitor used to study COVID-19-associated acute lung injury and impaired oxygenation. Target: Others. Smiles: C(=O)([C@@H]1CC=2NC(C=3C=4C(NN3)=CC(=CC4)C5=C(CC)C=C(O)C=C5)=NC2CN1C(C)C)N6CC(N(C)C)C6

Description: Filgotinib (maleate) is a selective, orally active JAK1 inhibitor that effectively inhibits the activity of JAK1 (IC50: 10 nM), JAK2 (IC50: 28 nM), JAK3 (IC50: 810 nM) and TYK2 (IC50: 116 nM). maleate) can be used to study rheumatoid arthritis (RA) and Crohn's disease. Target: Others. Smiles:...