337 products were found matching "K04441"!
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UM-164
Item number: TGM-T4597-100mg
Description: UM-164 (DAS-DFGO-II), a highly potent c-Src inhibitor with a dissociation constant (Kd) of 2.7 nM, also effectively inhibits p38alpha and p38beta. Target: p38 MAPK, Autophagy, Src. Smiles: Cc1nc(Nc2ncc(s2)C(=O)Nc2cc(NC(=O)c3cccc(c3)C(F)(F)F)ccc2C)cc(n1)N1CCN(CCO)CC1. References: Gilani RA, et al....
| Keywords: | DAS-DFGO-II, UM164 |
| Application: | Src inhibitor, p38 kinase inhibitor |
| CAS | 903564-48-7 |
| MW: | 640.68 D |
From 31.00€
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SB 242235
Item number: TGM-T4078-100mg
Description: SB 242235 is a potent and selective p38 MAP kinase inhibitor that may be an effective therapy for cytokine-mediated diseases. Target: p38 MAPK, Autophagy. Smiles: COc1nccc(n1)-c1c(ncn1C1CCNCC1)-c1ccc(F)cc1. References: Badger, A.M., et al., Differential effects of SB 242235, a selective p38...
| Keywords: | SB-242235, SB242235 |
| Application: | P38alpha MAPK inhibitor |
| CAS | 193746-75-7 |
| MW: | 353.39 D |
From 40.00€
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MW-150
Item number: TGM-T5494-100mg
Description: MW-150 (MW01-18-150SRM) is a unique, selective, CNS-penetrant, and orally active inhibitor of p38alpha MAPK with a Ki of 101 nM. Target: p38 MAPK, Autophagy. Smiles: CN1CCN(CC1)c1cc(-c2ccncc2)c(nn1)-c1ccc2ccccc2c1. References: Roy SM, et al. Targeting human central nervous system protein kinases: An...
| Keywords: | MW01-18-150SRM |
| Application: | P38alpha MAPK inhibitor |
| CAS | 1628502-91-9 |
| MW: | 381.47 D |
From 33.00€
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Doramapimod
Item number: TGM-T6277-100mg
Description: Doramapimod (BIRB 796) is a highly potent inhibitor of p38 MAPK (Kd: 0.1 nM), but weakly inhibits c-RAF, Fyn, Lck, ERK-1, SYK, IKK2, and ZAP-70. Target: Autophagy, p38 MAPK, Raf. Smiles: Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(OCCN2CCOCC2)c2ccccc12)C(C)(C)C. References: Pargellis C, et al. Inhibition of p38...
| Keywords: | BIRB 796 |
| Application: | Targets p38 MAP kinase [EC:2.7.11.24] (P38) |
| CAS | 285983-48-4 |
| MW: | 527.66 D |
From 32.00€
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SD 0006
Item number: TGM-T7276-100mg
Description: SD 0006 (SD-06) is a MAPK p38 alpha inhibitor with an IC50 of 110 nM, indicated for the treatment of arthritis. Target: p38 MAPK, Autophagy. Smiles: OCC(=O)N1CCC(CC1)c1n[nH]c(c1-c1ccncn1)-c1ccc(Cl)cc1. References: Walker J K , Selness S R , Devraj R V , et al. Identification of SD-0006, a potent diaryl...
| Keywords: | SD-06 |
| Application: | p38alpha MAPK inhibitor |
| CAS | 271576-80-8 |
| MW: | 397.86 D |
From 38.00€
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SB 239063
Item number: TGM-T6976-100mg
Description: SB 239063 (SB239063) is a potent and selective p38 MAPKalpha/beta inhibitor with IC50 of 44 nM, showing no activity against the gamma- and delta-kinase isoforms. Target: p38 MAPK, Autophagy. Smiles: COc1nccc(n1)-c1c(ncn1[C@H]1CC[C@H](O)CC1)-c1ccc(F)cc1. References: Underwood DC, et al. J Pharmacol Exp...
| Keywords: | SB239063 |
| Application: | p38 MAPK inhibitor |
| CAS | 193551-21-2 |
| MW: | 368.4 D |
From 43.00€
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R1487 Hydrochloride
Item number: TGM-T7162-2mg
Description: R1487 Hydrochloride (R1487 (Hydrochloride)) is an orally bioavailable and highly selective inhibitors of p38alpha. Target: Autophagy, p38 MAPK. Smiles: Cl.Cn1c2nc(NC3CCOCC3)ncc2cc(Oc2ccc(F)cc2F)c1=O. References: Goldstein DM, Soth M, Gabriel T,et al.Discovery of...
| Keywords: | R1487 (Hydrochloride) |
| Application: | p38alpha / MAPK14 inhibitor |
| CAS | 449808-64-4 |
| MW: | 424.83 D |
From 65.00€
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Acumapimod
Item number: TGM-T7367-100mg
Description: Acumapimod (BCT-197) is an orally active inhibitor of p38alpha MAPK (IC50 <1 µM). Target: p38 MAPK, Autophagy. Smiles: Cc1ccc(cc1-n1ncc(C(=O)c2cccc(c2)C#N)c1N)C(=O)NC1CC1. References: Growcott E J , Bamba D , Galarneau J . R , et al. The effect of P38 MAP kinase inhibition in a mouse model of...
| Keywords: | BCT-197 |
| Application: | p38 MAP kinase inhibitor |
| CAS | 836683-15-9 |
| MW: | 385.42 D |
From 31.00€
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SD-169
Item number: TGM-T7661-100mg
Description: SD-169 (SD 169) is a selective and ATP competitive the MAP kinases p38alpha and p38beta inhibitor. Target: p38 MAPK. Smiles: NC(=O)c1ccc2[nH]ccc2c1. References: Myers R R , Sekiguchi Y , Kikuchi S , et al. Inhibition of p38 MAP kinase activity enhances axonal regeneration[J]. Experimental Neurology,...
| Keywords: | SD 169 |
| Application: | MAP kinase p38alpha / p38beta inhibitor |
| CAS | 1670-87-7 |
| MW: | 160.17 D |
From 30.00€
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p38alpha inhibitor 4
Item number: TGM-T78652-10mg
Description: p38alpha inhibitor 4 is a selective MAPK p38alpha inhibitor, which is used to study diabetes, pain and chronic inflammation. Target: p38 MAPK. Smiles: O=C1C=C(C=2C(=NNC2N1)C=3C=CC=C(C3)C(F)(F)F)C(F)(F)F. References: Kenneth M Comess, et al. Discovery and characterization of non-ATP site inhibitors of...
| Application: | p38alpha inhibitor |
| CAS | 1262406-08-5 |
| MW: | 347.215 D |
From 286.00€
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MAPK14 Protein, Mouse, Recombinant (His & Myc)
Item number: TGM-TMPH-02786-100ug
Description: MAPK14 Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 48.6 kDa and the accession number is P47811.
| Keywords: | Mitogen-activated protein kinase p38 alpha, CRK1, Mitogen-activated protein kinase 14, Mapk14 |
| MW: | 48.6 kD |
From 278.00€
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p38 Protein, Human, Recombinant (His)
Item number: TGM-TMPY-04260-20ug
Description: MAPK14 contains 1 protein kinase domain and belongs to the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. MAPK14 can be...
| Keywords: | SAPK2A, p38alpha, CSBP1, p38, CSBP2, EXIP, RK, PRKM14, mitogen-activated protein kinase 14, CSPB1, PRKM15, Mxi2, CSBP,... |
| MW: | 43.7 kD |
587.00€
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