47 products were found matching "K04415"!
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Cot inhibitor-1
Item number: TGM-T10865-100mg
Description: Cot inhibitor-1 is a selective inhibitor of Cot protein kinase (also known as Tpl2 or MAP3K8) (IC50 at 28 nM). Cot inhibitor-1 inhibited TNF-alpha production in human whole blood with IC50 of 5.7 nM. Cot is involved in a variety of cellular signaling pathways, particularly those involved in inflammation...
| Application: | COT (MAP3K8) inhibitor |
| CAS | 915365-57-0 |
| MW: | 553.46 D |
From 69.00€
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Cot inhibitor-2
Item number: TGM-T10866-100mg
Description: Cot inhibitor-2 is a cot (Tpl2/MAP3K8) inhibitor (IC50: 1.6 nM) with potency, selectivity and oral activity. cot inhibitor-2 inhibits LPS-stimulated TNF-alpha production in human whole blood with an IC50 of 0.3 µM. Target: TNF, MAPK. Smiles:...
| Application: | COT (MAP3K8) inhibitor |
| CAS | 915363-56-3 |
| MW: | 539.43 D |
From 91.00€
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Tpl2 Kinase Inhibitor 1
Item number: TGM-T17145-10mg
Description: Tpl2 Kinase Inhibitor 1 is an effective and selective Tpl2 inhibitor. Target: Others. Smiles: Fc1ccc(Nc2c(cnc3cnc(NCc4cccnc4)cc23)C#N)cc1Cl
| Application: | Tpl2 Kinase (MAP3K8, COT) inhibitor |
| CAS | 871307-18-5 |
| MW: | 404.83 D |
From 140.00€
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MAP3K8 Protein, Human, Recombinant (GST)
Item number: TGM-TMPY-04389-50ug
Description: Mitogen-activated protein kinase kinase kinase 8, also known as Cancer Osaka thyroid oncogene, Proto-oncogene c-Cot, Serine/threonine-protein kinase cot, Tumor progression locus 2 and MAP3K8, is a cytoplasm protein that belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family and MAP...
| Keywords: | Tpl-2, c-COT, mitogen-activated protein kinase kinase kinase 8, AURA2, ESTF, COT, EST, MEKK8, TPL2 |
| MW: | 68 kD |
487.00€
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Anti-MAP3K8
Item number: CSB-PA001760.100
Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific...
| Keywords: | Anti-COT, Anti-TPL-2, Anti-MAP3K8, EC=2.7.11.25, Anti-Proto-oncogene c-Cot, Anti-Tumor progression locus 2, Anti-Cancer... |
| Application: | ELISA, WB, IHC, IF |
| Host: | Rabbit |
| Species reactivity: | human, mouse, rat |
From 106.00€
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Anti-MAP3K8
Item number: CSB-PA007158.50
Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific...
| Keywords: | Anti-COT, Anti-TPL-2, Anti-MAP3K8, EC=2.7.11.25, Anti-Proto-oncogene c-Cot, Anti-Tumor progression locus 2, Anti-Cancer... |
| Application: | ELISA, WB, IHC |
| Host: | Rabbit |
| Species reactivity: | human, mouse, rat |
106.00€
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Anti-Phospho-MAP3K8 (T290)
Item number: CSB-PA000735.100
Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific...
| Keywords: | Anti-phospho-COT, Anti-phospho-TPL-2, Anti-phospho-MAP3K8, EC=2.7.11.25, Anti-phospho-Proto-oncogene c-Cot,... |
| Application: | ELISA, WB, IHC, IF |
| Host: | Rabbit |
| Species reactivity: | human, mouse, rat |
From 106.00€
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Anti-Phospho-MAP3K8 (Ser400)
Item number: CSB-PA588716.100
Host Species: Rabbit. Isotype: IgG. Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antibodies were produced by immunizing rabbits with...
| Keywords: | Anti-phospho-COT, Anti-phospho-TPL-2, Anti-phospho-MAP3K8, EC=2.7.11.25, Anti-phospho-Proto-oncogene c-Cot,... |
| Application: | ELISA, IHC |
| Host: | Rabbit |
| Species reactivity: | human, mouse, rat |
330.00€
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Anti-MAP3K8 (Ab-400)
Item number: CSB-PA901361.100
Host Species: Rabbit. Isotype: IgG. Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by...
| Keywords: | Anti-COT, Anti-TPL-2, Anti-MAP3K8, EC=2.7.11.25, Anti-Proto-oncogene c-Cot, Anti-Tumor progression locus 2, Anti-Cancer... |
| Application: | ELISA, WB, IHC |
| Host: | Rabbit |
| Species reactivity: | human, mouse |
275.00€
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Tpl2 Kinase Inhibitor
Item number: Cay19710-1
Tpl2 kinase inhibitor is an inhibitor of tumor progression locus 2 (Tpl2, IC50 = 0.05 µM). It is selective for Tpl2 over MEK, p38 MAPK, Src, MK2, and PKC (IC50s = >40, 180, >400, 110, and >400 µM, respectively). Tpl2 kinase inhibitor inhibits LPS-induced TNF-alpha production in isolated human monocytes and whole...
| Keywords: | c-Cot Kinase Inhibitor, MAP3K8 Kinase Inhibitor, Tumor Progression Locus 2 Kinase Inhibitor,... |
| Application: | c-Cot (MAP3K8) inhibitor |
| CAS | 871307-18-5 |
| MW: | 404.8 D |
From 77.00€
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Tpl2 Kinase Inhibitor (hydrochloride)
Item number: Cay34059-1
Tpl2 kinase inhibitor is an inhibitor of tumor progression locus 2 (Tpl2, IC50 = 0.05 µM). It is selective for Tpl2 over MEK, p38 MAPK, Src, MK2, and PKC (IC50s = >40, 180, >400, 110, and >400 µM, respectively). Tpl2 kinase inhibitor inhibits LPS-induced TNF-alpha production in isolated human monocytes and whole...
| Keywords: | c-Cot Kinase Inhibitor, MAP3K8 Kinase Inhibitor, Tumor Progression Locus 2 Kinase Inhibitor,... |
| Application: | MAP3K8/COT/Tpl2 inhibitor |
| MW: | 404.8 D |
From 77.00€
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Cot (MAP3K8), GST-His-tags
Item number: BPS-40050
Human Cot/Tpl2 (GenBank Accession No. NM_005204), (a.a. 30-397), with N-terminal GST-His-tag, MW= 72 kDa, expressed in a Baculovirus infected Sf9 cell expression system.
| Keywords: | COT, TPL-2, MAP3K8, EC=2.7.11.25, Proto-oncogene c-Cot, Tumor progression locus 2, Cancer Osaka thyroid oncogene,... |
| Application: | Enzyme kinetics, inhibitor screening, selectivity profiling |
| Expressed in: | insect cells |
| Origin: | human |
| MW: | 72 kD |
525.00€
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