32 products were found matching "K04407"!
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PF-06260933
Item number: TGM-T4221-100mg
Description: PF-06260933 is a highly selective small-molecule MAP4K4 inhibitor with IC50s of 3.7 and 160 nM for kinase and cell, respectively. Target: MAPK. Smiles: Nc1ccc(cn1)-c1cnc(N)c(c1)-c1ccc(Cl)cc1. References: Ammirati M, et al. Discovery of an in Vivo Tool to Establish Proof-of-Concept for MAP4K4-Based...
| Keywords: | PF6260933, PF-6260933, PF 6260933 |
| Application: | MAP4K4 inhibitor |
| CAS | 1811510-56-1 |
| MW: | 296.75 D |
From 42.00€
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GNE-495
Item number: TGM-TQ0079-10mg
Description: GNE-495 is a potent and specific inhibitor of MAP4K4 with an IC50 of 3.7 nM. Target: MAPK. Smiles: Nc1ncc(C(=O)NC2CN(C2)C(=O)C2CC2)c2ccc(nc12)-c1cccc(F)c1. References: Ndubaku CO et al. Structure-Based Design of GNE-495, a Potent and Selective MAP4K4 Inhibitor with Efficacy in Retinal Angiogenesis. ACS...
| Application: | MAP4K4 inhibitor |
| CAS | 1449277-10-4 |
| MW: | 405.42 D |
From 65.00€
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Anti-MAP4K4
Item number: CSB-PA002905.100
Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific...
| Keywords: | Anti-HGK, Anti-MAP4K4, Anti-MEKKK 4, EC=2.7.11.1, Anti-MEK kinase kinase 4, Anti-Nck-interacting kinase, Anti-HPK/GCK-like... |
| Application: | ELISA, WB, IF |
| Host: | Rabbit |
| Species reactivity: | human, mouse |
From 126.00€
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Anti-MAP4K4/HGK
Item number: A301-503A
Protein function: Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322. [The UniProt Consortium]
| Keywords: | Anti-HGK, Anti-MAP4K4, Anti-MEKKK 4, EC=2.7.11.1, Anti-MEK kinase kinase 4, Anti-Nck-interacting kinase, Anti-HPK/GCK-like... |
| Application: | WB, IP |
| Host: | Rabbit |
| Species reactivity: | human |
From 178.00€
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GNE-495
Item number: Cay21808-1
GNE-495 is an orally bioavailable, potent, and selective MAP4K4 inhibitor (IC50 = 3.7 nM). In cell sprouting assays, it increases the number of protrusions. In a mouse model of oxygen-induced retinopathy, GNE-495 normalizes the percentage of pathological vessels and hemorrhagic areas.Formal Name:...
| Keywords: | 8-amino-N-[1-(cyclopropylcarbonyl)-3-azetidinyl]-2-(3-fluorophenyl)-1,7-naphthyridine-5-carboxamide |
| Application: | MAP4K4 inhibitor |
| CAS | 1449277-10-4 |
| MW: | 405.4 D |
From 61.00€
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Anti-MAP4K4/HGK
Item number: A301-502A
Protein function: Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322. [The UniProt Consortium]
| Keywords: | Anti-HGK, Anti-MAP4K4, Anti-MEKKK 4, EC=2.7.11.1, Anti-MEK kinase kinase 4, Anti-Nck-interacting kinase, Anti-HPK/GCK-like... |
| Application: | WB, IP, IHC |
| Host: | Rabbit |
| Species reactivity: | human |
From 178.00€
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Anti-MAP4K4/HGK (IHC)
Item number: IHC-00536
Protein function: Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322. [The UniProt Consortium]
| Keywords: | Anti-HGK, Anti-MAP4K4, Anti-MEKKK 4, EC=2.7.11.1, Anti-MEK kinase kinase 4, Anti-Nck-interacting kinase, Anti-HPK/GCK-like... |
| Application: | IHC |
| Host: | Rabbit |
| Species reactivity: | human |
From 178.00€
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Anti-NIK (Nck-interacting kinase)
Item number: NSJ-F50948-0.08ML
In 1X PBS, pH 7.4, with 0.09% sodium azide. HGK/NIK, a member of the STE20 subfamily of Ser/Thr protein kinases, may play a role in the response to environmental stress and cytokines such as TNF-alpha. It appears to act upstream of the JUN N-terminal pathway. This protein is thought to interact with the SH3 domain...
| Keywords: | Anti-HGK, Anti-MAP4K4, Anti-MEKKK 4, EC=2.7.11.1, Anti-MEK kinase kinase 4, Anti-Nck-interacting kinase, Anti-HPK/GCK-like... |
| Application: | WB, ELISA |
| Host: | Rabbit |
| Species reactivity: | human |
From 350.00€
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Anti-MAP4K4
Item number: ATA-HPA008476.100
Protein function: Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr- 322. [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added...
| Keywords: | Anti-HGK, Anti-MAP4K4, Anti-MEKKK 4, EC=2.7.11.1, Anti-MEK kinase kinase 4, Anti-Nck-interacting kinase, Anti-HPK/GCK-like... |
| Application: | IHC, WB |
| Host: | Rabbit |
| Species reactivity: | human |
From 320.00€
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PF-6260933
Item number: Cay29220-10
PF-6260933 is an inhibitor of mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4, IC50 = 3.7 nM). It is selective for MAP4K4 over a panel of 41 kinases at 1 µM but also inhibits TRAF2- and NCK-interacting kinase (TNIK) and misshapen-like kinase 1 (MINK1, IC50s = 15 and 8 nM, respectively). PF-6260933...
| Keywords: | PF-06260933, 5-(4-chlorophenyl)-3,3'-bipyridine]-6,6'-diamine |
| Application: | MAP4K4 inhibitor |
| CAS | 1811510-56-1 |
| MW: | 296.8 D |
From 153.00€
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MAP4K4 (human), recombinant protein
Item number: ABS-PP-10642.20
| Keywords: | Mitogen-activated protein kinase kinase kinase kinase 4, HPK/GCK-like kinase HGK, MAPK/ERK kinase kinase kinase 4, MEK... |
| Expressed in: | E.coli |
| Origin: | human |
| MW: | 13 kD |
From 90.00€
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Anti-MAP4K4
Item number: CSB-PA013439LA01HU.100
Host Species: Rabbit. Isotype: IgG. Buffer: Preservative: 0.03% Proclin 300Constituents: 50% Glycerol, 0.01M PBS, pH 7.4. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen Affinity Purified. Target Name: MAP4K4. Antigen Species: Human
| Keywords: | Anti-HGK, Anti-MAP4K4, Anti-MEKKK 4, EC=2.7.11.1, Anti-MEK kinase kinase 4, Anti-Nck-interacting kinase, Anti-HPK/GCK-like... |
| Application: | ELISA, WB, IHC, IF |
| Host: | Rabbit |
| Species reactivity: | human, mouse |
From 167.00€
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