192 products were found matching "K04366"!
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LXH254
Item number: LKT-L930280.1
LXH254 is a type II RAF inhibitor. SMILES: CC1=C(C=C(C=C1)NC(=O)C2=CC(=NC=C2)C(F)(F)F)C3=CC(=NC(=C3)OCCO)N4CCOCC4
| Keywords: | Naporafenib,... |
| Application: | pan-RAF inhibitor |
| CAS | 1800398-38-2 |
| MW: | 502.49 D |
From 84.00€
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RAF709
Item number: TGM-T3711-100mg
Description: RAF709 is a novel Raf kinase inhibitor with IC50s of 0.5 and 1.8 nM for c-Raf and b-Raf, respectively. Target: Raf. Smiles: Cc1ncc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1cnc(OC2CCOCC2)c(c1)N1CCOCC1. References: Robert AVERSA, et al. Biaryl amide compounds as kinase inhibitors. WO2014151616A1.
| Application: | B-RAF / C-RAF inhibitor |
| CAS | 1628838-42-5 |
| MW: | 542.55 D |
From 34.00€
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CCT196969
Item number: TGM-T4133-100mg
Description: CCT196969 is a novel orally available, pan-RAF inhibitor with anti-SRC activity. It also inhibits SRC, LCK, and the p38 MAPKs. Target: Src, Raf. Smiles: CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)cnc34)cc2F)n(n1)-c1ccccc1. References: Girotti MR,etal.Paradox-breaking RAF inhibitors that also target SRC...
| Application: | Multi-kinase inhibitor |
| CAS | 1163719-56-9 |
| MW: | 513.52 D |
From 31.00€
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Ro 5126766
Item number: TGM-T6971-100mg
Description: RO5126766 (CH5126766) is a dual RAF/MEK inhibitor with IC50 of 8.2 nM, 19 nM, 56 nM, and 160 nM for BRAF V600E, BRAF, CRAF, and MEK1, respectively. Phase 1. Target: Raf, MEK. Smiles: CNS(=O)(=O)Nc1nccc(Cc2c(C)c3ccc(Oc4ncccn4)cc3oc2=O)c1F. References: Ishii N, et al. Cancer Res. 2013, 73(13), 4050-4060.
| Keywords: | CH5126766, Avutometinib, RO5126766, VS-6766 |
| Application: | Targets mitogen-activated protein kinase kinase 1 [EC:2.7.12.2] (MAP2K1, MEK1) |
| CAS | 946128-88-7 |
| MW: | 471.46 D |
From 52.00€
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Avutometinib potassium
Item number: TGM-T68270-100mg
Description: Avutometinib potassium is a MEK inhibitor (MEKi) that enhanced the inhibition of pseudovirus infection by GLPG-0187. It Blocks SARS-CoV-2 Delta and Omicron Pseudovirus Infection of Airway Epithelial Cells In Vitro, Which Could Attenuate Disease Severity. Target: Others. Smiles:...
| Application: | Targets mitogen-activated protein kinase kinase 1 [EC:2.7.12.2] (MAP2K1, MEK1) |
| CAS | 946128-90-1 |
| MW: | 509.55 D |
From 1,671.00€
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CCT241161
Item number: TGM-T9638-100mg
Description: CCT241161 is an orally active pan-RAF inhibitor, with IC50 values of 3, 6, 10, 15, and 30 nM for LCK, CRAF, SRC, V600E-BRAF, and BRAF, respectively. It exhibits significant activity against BRAF and NRAS mutant melanomas and demonstrates anticancer cell proliferative effects [1]. Target: Raf. Smiles:...
| Application: | Multi-kinase inhibitor |
| CAS | 1163719-91-2 |
| MW: | 541.62 D |
From 139.00€
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RAF1 Protein, Human, Recombinant (His & SUMO)
Item number: TGM-TMPH-01995-100ug
Description: RAF1 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 89.1 kDa and the accession number is P04049.
| Keywords: | RAF1, Raf-1, Proto-oncogene c-RAF, RAF proto-oncogene serine/threonine-protein kinase |
| MW: | 89.1 kD |
From 198.00€
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RAF1 Protein, Human, Recombinant (His & GST)
Item number: TGM-TMPY-05095-50ug
Description: RAF1 gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual...
| Keywords: | NS5, CRAF, CMD1NN, Raf-1 proto-oncogene, serine/threonine kinase, Raf-1, c-Raf |
| MW: | 66.9 kD |
497.00€
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BI-882370
Item number: TGM-TQ0048-10mg
Description: BI-882370 is a specific RAF kinase inhibitor. BI-882370 inhibits the oncogenic BRAFV600E-mutant, the WT BRAF and CRAF kinases (IC50s: 0.4, 0.8 and 0.6 nM). BI-882370 also inhibits SRC family kinases. Target: Raf. Smiles: CCCS(=O)(=O)Nc1ccc(F)c(c1F)-n1cc(-c2cncnc2)c2nc(ccc12)N(C)C1CCN(CC)CC1. References:...
| Application: | RAF inhibitor |
| CAS | 1392429-79-6 |
| MW: | 569.67 D |
From 37.00€
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B-Raf IN 1
Item number: TGM-T1845-100mg
Description: B-Raf IN 1 is an inhibitor of B-Raf (IC50: 24 nM) and c-Raf (IC50: 25 nM). Target: Raf. Smiles: CN(C)Cc1ccc(cc1)-c1cnn2c(ccnc12)-c1cccc(NC(=O)c2cccc(c2)C(F)(F)F)c1. References: Berger DM, et al. Bioorg Med Chem Lett. 2009 Dec 1,19(23):6519-23.
| Application: | BRAF / RAF1 inhibitor |
| CAS | 950736-05-7 |
| MW: | 515.53 D |
From 83.00€
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ZM 336372
Item number: TGM-T1851-100mg
Description: ZM 336372 is a potent and selective c-Raf inhibitor. Target: Raf, Apoptosis. Smiles: CN(C)c1cccc(c1)C(=O)Nc1ccc(C)c(NC(=O)c2ccc(O)cc2)c1. References: Hall-Jackson CA, et al. Chem Biol, 1999, 6(8), 559-568.
| Keywords: | Zinc00581684 |
| Application: | Raf-1 inhibitor |
| CAS | 208260-29-1 |
| MW: | 389.45 D |
From 34.00€
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GW 5074
Item number: TGM-T6525-100mg
Description: GW 5074 (Raf1 Kinase Inhibitor I)(IC50=9 nM) is an effective and specific c-Raf inhibitor. It has no effect on the activities of JNK1/2/3, MEK1, MKK6/7, CDK1/2, c-Src, p38 MAP, VEGFR2 or c-Fms. Target: Apoptosis, Raf. Smiles: C(=C1C=2C(NC1=O)=CC=C(I)C2)C3=CC(Br)=C(O)C(Br)=C3. References: Chin PC, et...
| Keywords: | Raf1 Kinase Inhibitor I, GW5074 |
| Application: | Raf-1 inhbitor |
| CAS | 220904-83-6 |
| MW: | 520.94 D |
From 37.00€
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