192 products were found matching "K04365"!
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Plx-4032
Item number: TGM-T8654-500mg
Description: Plx-4032 (Vemurafenib) is a small-molecule B-Raf inhibitor for the potential treatment of malignant melanoma. Target: Raf. Smiles: CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(cc23)-c2ccc(Cl)cc2)c1F. References: Smalley K S M . PLX-4032, a small-molecule B-Raf inhibitor for the potential treatment of...
| Keywords: | Vemurafenib |
| Application: | B-Raf (V600E) inhibitor |
| CAS | 1029872-54-5 |
| MW: | 489.92 D |
From 49.00€
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Anti-BRAF V600E
Item number: ABS-KC-2309.100
Protein function: Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway (PubMed:21441910, PubMed:29433126). May play a role in the postsynaptic responses of hippocampal...
| Keywords: | Anti-Serine/threonine-protein kinase B-raf, Anti-Proto-oncogene B-Raf, Anti-p94, Anti-v-Raf murine sarcoma viral oncogene... |
| Application: | IP |
| Host: | Mouse |
| Species reactivity: | human |
From 206.00€
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Anti-BRAF
Item number: ABS-KC-2310.100
Protein function: Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway (PubMed:21441910, PubMed:29433126). May play a role in the postsynaptic responses of hippocampal...
| Keywords: | Anti-Serine/threonine-protein kinase B-raf, Anti-Proto-oncogene B-Raf, Anti-p94, Anti-v-Raf murine sarcoma viral oncogene... |
| Application: | IP |
| Host: | Mouse |
| Species reactivity: | human |
From 206.00€
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Anti-BRAF V600E
Item number: ABS-OC-176.100
Protein function: Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway (PubMed:21441910, PubMed:29433126). May play a role in the postsynaptic responses of hippocampal...
| Keywords: | Anti-Serine/threonine-protein kinase B-raf, Anti-Proto-oncogene B-Raf, Anti-p94, Anti-v-Raf murine sarcoma viral oncogene... |
| Application: | IP |
| Host: | Mouse |
| Species reactivity: | human |
From 206.00€
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Dabrafenib
Item number: TGM-T1903-1mL
Description: Dabrafenib (GSK2118436A) is a Raf inhibitor that inhibits C-Raf and B-RafV600E (IC50=5/0.6 nM) and is ATP-competitive. Dabrafenib exhibits antitumor activity for the treatment of B-RafV600E-mutated melanoma. Target: Raf. Smiles: CC(C)(C)c1nc(c(s1)-c1ccnc(N)n1)-c1cccc(NS(=O)(=O)c2c(F)cccc2F)c1F....
| Keywords: | GSK2118436A, GSK2118436 |
| Application: | Targets B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1] (BRAF) |
| CAS | 1195765-45-7 |
| MW: | 519.56 D |
From 42.00€
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Encorafenib
Item number: TGM-T6487-5mg
Description: Encorafenib (LGX818) is an orally available mutated BRaf V600E inhibitor(IC50=0.3 nM) with potential antineoplastic activity. Target: Raf. Smiles: COC(=O)N[C@@H](C)CNc1nccc(n1)-c1cn(nc1-c1cc(Cl)cc(NS(C)(=O)=O)c1F)C(C)C. References: Darrin D Stuart, et al. Cancer Res, 2012, 72(8 Supplement): 3790
| Keywords: | LGX818 |
| Application: | B-Raf V600E mutant inhibitor |
| CAS | 1269440-17-6 |
| MW: | 540.01 D |
From 46.00€
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TAK-632
Item number: TGM-T1886-100mg
Description: TAK-632, a potent pan-Raf inhibitor (GenScript, 2020), is characterized by its molecular weight [M] for [C 22 H 19 FN 2 O 2] of 362.4 by LC-MS, with a purity of 99% (HPLC). The compound exhibits white to off-white solid form and has a melting point [M] ranging from 178°C to 182°C (GenScript, 2020). Its...
| Application: | RAF inhibitor |
| CAS | 1228591-30-7 |
| MW: | 554.52 D |
From 37.00€
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BRAF inhibitor
Item number: TGM-T10599-100mg
Description: BRAF inhibitor is an inhibitor of B-Raf. Target: Raf. Smiles: CC(C)S(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(cc23)-c2cccnc2)c1F. References: Prahbha N. Ibrahim, et al. Pyrrolo[2,3-b] pyridine derivatives as protein kinase inhibitors. WO2007002325A1.
| Application: | BRAF inhibitor |
| CAS | 918505-61-0 |
| MW: | 456.47 D |
From 40.00€
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LXH254
Item number: TGM-T11898-100mg
Description: LXH254 is a potent C-Raf and B-Raf inhibitor. Target: Raf. Smiles: Cc1ccc(NC(=O)c2ccnc(c2)C(F)(F)F)cc1-c1cc(OCCO)nc(c1)N1CCOCC1. References: CAPONIGRO, Giordano, et al. THERAPEUTIC COMBINATIO NSCOMPRISI NGARAFINHI BITORANDAE RKINHIBITO R. WO 2018051306 A1 20180322
| Application: | Targets B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1] (BRAF) |
| CAS | 1800398-38-2 |
| MW: | 502.49 D |
From 48.00€
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Agerafenib
Item number: TGM-T2070-100mg
Description: Agerafenib (CEP32496) is a highly potent inhibitor of BRAF. Target: PDGFR, Bcr-Abl, c-RET, Src, Raf, c-Kit. Smiles: COc1cc2ncnc(Oc3cccc(NC(=O)Nc4cc(on4)C(C)(C)C(F)(F)F)c3)c2cc1OC. References: Rowbottom MW, et al. J Med Chem, 2012, 55(3), 1082-1105.
| Keywords: | CEP 32496, CEP-32496, CEP32496, RXDX-105 |
| Application: | Raf inhibitor |
| CAS | 1188910-76-0 |
| MW: | 517.46 D |
From 37.00€
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Raf inhibitor 1
Item number: TGM-T2074-100mg
Description: B-Raf inhibitor 1 (B-Raf inhibitor 1) is a potent and selective B-Raf inhibitor. Target: Raf. Smiles: Cc1ccc2c(Nc3ccc(Cl)cc3)nccc2c1Nc1ncccc1-c1ncnc2nc[nH]c12. References: Wang X, et al. J Med Chem. 2012 Sep 13,55(17): 7332-41.
| Keywords: | B-Raf inhibitor 1 |
| Application: | B-Raf inhibitor |
| CAS | 1093100-40-3 |
| MW: | 478.94 D |
From 33.00€
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PLX8394
Item number: TGM-T3579-100mg
Description: PLX8394 is an orally active inhibitor of serine/threonine-protein kinase B-Raf (BRAF) protein. PLX8394 can selectively bind to and inhibit the activity of both wild-type and mutated forms of BRAF, then inhibit the proliferation of tumor cells which express mutated forms of BRAF. PLX8394 appears to be...
| Application: | RAF inhibitor |
| CAS | 1393466-87-9 |
| MW: | 542.53 D |
From 45.00€
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