837 products were found matching "K04361"!
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Erlotinib
Item number: Cay10483-250
Erlotinib is an EGFR inhibitor (Ki = 2.7 nM). It is greater than 1,000-fold selective for EGFR over Src and Abl at 0.1 µM. Erlotinib induces caspase-3 and -7 activity in NCI H358 non-small cell lung cancer (NSCLC) cells when used at a concentration of 1 µM. Erlotinib (25 mg/kg) reduces EGF-induced EGFR...
| Keywords: | NSC 718781, N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine |
| Application: | Tyrosine kinase inhibitor |
| CAS | 183321-74-6 |
| MW: | 393.4 D |
From 43.00€
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PD153035
Item number: TGM-T2041-100mg
Description: PD153035 (NSC-669364) hydrochloride is an effective and selective inhibitor of EGFR (Ki/IC50: 5.2/29 pM, in cell-free assays), little inhibitory against FGFR, PGDFR, InsR, CSF-1 and Src. Target: EGFR. Smiles: COC1=CC2=NC=NC(NC3=CC(Br)=CC=C3)=C2C=C1OC. References: Fry DW, et al. Science. 1994, 265(5175),...
| Keywords: | AG1517, NSC 669364, ZM 252868, SU-5271 |
| Application: | EGFR inhibitor |
| CAS | 153436-54-5 |
| MW: | 360.21 D |
From 39.00€
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AG-1478
Item number: TGM-T2047-100mg
Description: AG-1478 (NSC-693255) (Tyrphostin AG-1478) is a selective EGFR inhibitor. Target: HER, PDGFR, EGFR, HCV Protease, Influenza Virus. Smiles: N(C=1C2=C(C=C(OC)C(OC)=C2)N=CN1)C3=CC(Cl)=CC=C3. References: Levitzki A, et al. Science, 1995, 267(5205), 1782-1788.
| Keywords: | Tyrphostin AG-1478, NSC 693255, AG1478 |
| Application: | EGF receptor kinase inhibitor |
| CAS | 153436-53-4 |
| MW: | 315.75 D |
From 45.00€
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AEE788
Item number: TGM-T2116-100mg
Description: AEE788 (NVP-AEE 788) has been used in trials studying the treatment of Cancer, Glioblastoma Multiforme, and Brain and Central Nervous System Tumors. Target: Bcr-Abl, FLT, EGFR, Apoptosis, c-Fms. Smiles: CCN1CCN(Cc2ccc(cc2)-c2cc3c(N[C@H](C)c4ccccc4)ncnc3[nH]2)CC1. References: Traxler P, et al. Cancer...
| Keywords: | NVP-AEE 788 |
| Application: | EGFR & HER2/ErbB2 inhibitor |
| CAS | 497839-62-0 |
| MW: | 440.58 D |
From 39.00€
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Tyrphostin A25
Item number: TGM-T21622-100mg
Description: Tyrphostin A25 (Tyrphostin AG 82) is a specific EGFR tyrosine kinase inhibitor and GPR35 agonist with an IC50 value of 0.94 µM for GPR35 and an EC50 value of 5.3 µM for GPR35. Target: EGFR, GPR. Smiles: C(=C(C#N)C#N)C1=CC(O)=C(O)C(O)=C1. References: Klemke RL, et al. Receptor tyrosine kinase signaling...
| Keywords: | AG-82, RG-50875, Tyrphostin AG 82 |
| Application: | EGF receptor kinase inhibitor |
| CAS | 118409-58-8 |
| MW: | 202.17 D |
From 50.00€
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Mavelertinib
Item number: TGM-T21322-1mg
Description: Mavelertinib (PF-06747775) is an orally available, selective and potent EGFR tyrosine kinase (EGFR TKI) inhibitor with inhibitory effects on T790M/L858R and T790M/Del, and can be used in the study of oncology and respiratory diseases. Target: EGFR. Smiles:...
| Keywords: | PF6747775, PF-06747775, PF 06747775, PFE-X775, PF-7775, PF 6747775 |
| Application: | Targets epidermal growth factor receptor [EC:2.7.10.1] (EGFR, ERBB1) |
| CAS | 1776112-90-3 |
| MW: | 415.42 D |
From 60.00€
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AG-183
Item number: TGM-T21783-5mg
Description: (Z)-Tyrphostin A51, the Z configuration of Lanoconazole A51, is a potent protein tyrosine kinase (PTK) inhibitor that dose-dependently inhibits the volume-sensitive release of [3 H]taurine in primary astrocyte cultures. It significantly reduces cellular tyrosyl phosphorylation levels and inhibits both...
| Application: | EGF receptor kinase inhibitor |
| CAS | 122520-90-5 |
| MW: | 268.23 D |
From 96.00€
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Varlitinib Tosylate
Item number: TGM-T20954-25mg
Description: Varlitinib Tosylate is a selective and potent inhibitor of ErbB1(EGFR) and ErbB2(HER2). Target: Others. Smiles: O=S(O)(C1=CC=C(C=C1)C)=O.C[C@H](CO2)N=C2NC3=CC(C(NC4=CC(Cl)=C(C=C4)OCC5=NC=CS5)=NC=N6)=C6C=C3.O=S(O)(C7=CC=C(C=C7)C)=O
| Keywords: | ARRY-334543 Tosylate, ARRY-543 Tosylate, Varlitinib-Tosylate |
| Application: | Targets epidermal growth factor receptor [EC:2.7.10.1] (EGFR, ERBB1) |
| CAS | 1146629-86-8 |
| MW: | 811.34 D |
1,491.00€
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Dacomitinib hydrate
Item number: TGM-T19965-1mg
Description: Dacomitinib hydrate (PF 299804) is a highly selective and second-generation small-molecule inhibitor of the pan-epidermal growth factor receptor family of tyrosine kinases. Dacomitinib specifically and irreversibly binds to and inhibits human EGFR subtypes, resulting in inhibition of proliferation and...
| Keywords: | PF-00299804, PF299804, PF 00299804, PF-299804, PF00299804, PF 299804 |
| Application: | Targets epidermal growth factor receptor [EC:2.7.10.1] (EGFR, ERBB1) |
| CAS | 1042385-75-0 |
| MW: | 487.96 D |
From 32.00€
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Nazartinib
Item number: TGM-T3506-100mg
Description: Nazartinib (EGF816) (EGF816, NVS-816) is a covalent, irreversible, mutant-selective EGFR inhibitor that has nanomolar inhibitory potency against activating mt (L858R, ex19del) and T790M mt, with up to 60-fold selectivity over wild type (wt) EGFR in vitro. Target: EGFR. Smiles:...
| Keywords: | EGF816, NVS-816 |
| Application: | Targets epidermal growth factor receptor [EC:2.7.10.1] (EGFR, ERBB1) |
| CAS | 1508250-71-2 |
| MW: | 495.02 D |
From 32.00€
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RG14620
Item number: TGM-T3554-100mg
Description: RG14620 (Tyrphostin RG14620) is an epidermal growth factor receptor (EGFR) inhibitor. Target: HER, EGFR. Smiles: Clc1cc(Cl)cc(C=C(C#N)c2cccnc2)c1. References: Yoneda T, et al. The antiproliferative effects of tyrosine kinase inhibitors tyrphostins on a human squamous cell carcinoma in vitro and in nude...
| Keywords: | RG 14620, Tyrphostin RG14620 |
| Application: | EGF receptor kinase inhibitor |
| CAS | 136831-49-7 |
| MW: | 275.13 D |
From 31.00€
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PD 174265
Item number: TGM-T28339-100mg
Description: PD 174265 is an effective, selective and reversible inhibitor of epidermal growth factor receptor (EGFR) with an IC50 of 0.45 nM. Target: EGFR. Smiles: CCC(=O)Nc1ccc2ncnc(Nc3cccc(Br)c3)c2c1. References: Fry DW, et al. Specific, irreversible inactivation of the epidermal growth factor receptor and erbB2,...
| Keywords: | PD-174265, N-{4-[(3-Bromophenyl)amino]quinazolin-6-Yl}propanamide, PD174265 |
| Application: | Cell-permeable EGFR inhibitor |
| CAS | 216163-53-0 |
| MW: | 371.23 D |
From 50.00€
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