32 products were found matching "K04295"!

Description: A-971432 is a sphingosine-1-phosphate receptor 5 (S1P5) agonist that is selective for S1P5 over S1P1 and S1P3 (IC50s = 0.006, 0.362, and >10 µM, respectively). It inhibits forskolin-induced cAMP production in CHO cells expressing S1P5 (EC50 = 4.1 nM). A-971432 (1 µM) increases electrical resistance of...

Description: GSK2018682 is an agonist of sphingosine-1-phosphate receptor (s1p1) and (s1p5) agonist(pEC50s of 7.7 and 7.2,respectively). Target: S1P Receptor, LPL Receptor. Smiles: CC(C)Oc1ncc(cc1Cl)-c1nc(no1)-c1cccc2n(CCCC(O)=O)ccc12. References: Xu J , Gray F , Henderson A , et al. Safety, pharmacokinetics,...

Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: S1PR5. Antigen Species: Human

Ozanimod is a sphingosine-1-phosphate receptor 1 (S1P1) and S1P5 agonist. It induces GTPgammaS binding in cell membranes expressing human S1P1 or S1P5 (EC50s = 0.41 and 11 nM, respectively) but not cell membranes expressing S1P2 or S1P3 receptors (EC50s = >10,000 nM for both). Ozanimod (0.2 mg/kg) reduces the number...

Siponimod is an agonist of sphingosine-1-phosphate receptor 1 (S1P1) and S1P5. It is selective for S1P1 and S1P5 over S1P2, S1P3, and S1P4 (EC50s = 0.39, 0.98, >10,000, >1,000, and 750 nM, respectively, in GTP-gammaS binding assays). Siponimod (10 nM) reduces demyelination induced by lysophosphatidylcholine or...

A-971432 is a sphingosine-1-phosphate receptor 5 (S1P5) agonist that is selective for S1P5 over S1P1 and S1P3 (IC50s = 0.006, 0.362, and >10 µM, respectively). It inhibits forskolin-induced cAMP production in CHO cells expressing S1P5 (EC50 = 4.1 nM). A-971432 (1 µM) increases electrical resistance of hCMEC/D3 cells...

Sphingosine 1-phosphate (S1P) receptor EDG-8 is a multi-pass membrane protein belonging to the G protein-coupled receptor 1 family and coupled to both the Gi/0a and G12 subclass of heteromeric G-proteins. EDG-8 acts as a receptor for the bioactive sphingolipid S1P as well as for lysophosphatidic acid (LPA) and gives...

0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide. Additional name(s) for this target protein: Endothelial differentiation, sphingolipid G-protein-coupled receptor, 8, sphingosine-1-phosphate receptor 5 (S1PR5) Protein function: Receptor for the lysosphingolipid sphingosine 1- phosphate...

In 1X PBS, pH 7.4, with 0.09% sodium azide. The lysosphingolipid sphingosine 1-phosphate (S1P) regulates cell proliferation, apoptosis, motility, and neurite retraction. Its actions may be both intracellular as a second messenger and extracellular as a receptor ligand. S1P and the structurally related lysolipid...

Ceralifimod is an agonist of the sphingosine-1-phosphate (S1P) receptors S1P1 and S1P5 (Kis = 0.626 and 0.574 nM, respectively). It is selective for S1P1 and S1P5 over S1P2-4 (Kis = >5,450, >5,630, and 28.8 nM, respectively). Ceralifimod induces calcium influx in CHO-K1 cells overexpressing S1P1 (EC50 = 1 nM) and...