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CS 2100
Item number: Cay14396-10
CS 2100 is a sphingosine-1-phosphate receptor 1 (S1P1) agonist. It selectively induces GTPgammaS binding in CHO-K1 cells expressing human or rat S1P1 (EC50s = 4 and 1.5 nM, respectively) over those expressing human or rat S1P3 (EC50s = >20 and 7.4 µM, respectively). CS 2100 (0.1 and 1 mg/kg) transiently reduces...
| Keywords: | 1-[[4-ethyl-5-[5-(4-phenoxyphenyl)-1,2,4-oxadiazol-3-yl]-2-thienyl]methyl]-3-azetidinecarboxylic acid |
| Application: | S1P1 agonist |
| CAS | 913827-99-3 |
| MW: | 461.5 D |
From 136.00€
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Sphingosine-1-phosphate
Item number: TGM-T21500-1mg
Description: Sphingosine-1-phosphate (S1P) is an agonist for S1P1-5 receptors and a ligand for GPR3, GPR6, and GPR12. As an intracellular second messenger, it mobilizes Ca2+ and acts as an extracellular ligand for G-protein coupled receptors. This important lipid mediator is generated from sphingosine (HY-113498) or...
| Keywords: | S1P |
| Application: | Bioactive lipid mediator |
| CAS | 26993-30-6 |
| MW: | 379.47 D |
292.00€
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CYM5442
Item number: TGM-T2026-1mg
Description: CYM5442 is an S1P agonist, targeting to Sphingosine. Target: S1P Receptor, LPL Receptor. Smiles: CCOc1ccc(cc1OCC)-c1nc(no1)-c1cccc2C(CCc12)NCCO. References: Poti F, et al. Vascul Pharmacol. 2012 Aug 19,57(1):56-64.
| Application: | S1PR1 internalization, phosphorylation, ubiquitination agonist |
| CAS | 1094042-01-9 |
| MW: | 409.48 D |
From 39.00€
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Mocravimod
Item number: TGM-T28080-100mg
Description: Mocravimod is an agonist of sphingosine 1-phosphate receptor type 1. Mocravimod ameliorates atherosclerosis in LDL-R-/- mice. KRP-203 attenuates rat autoimmune myocarditis. KRP-203 combined with cyclosporine prolonged graft survival and abrogated transplant vasculopathy in rat heart allografts. Target:...
| Keywords: | KRP 203 free base, KRP-203, KRP203 |
| Application: | Targets sphingosine 1-phosphate receptor 1 (S1PR1, EDG1, CD363) |
| CAS | 509092-16-4 |
| MW: | 443.99 D |
From 1,491.00€
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NIBR-0213
Item number: TGM-T28169-10mg
Description: NIBR-0213, a potent and selective S1P(1) antagonist, has efficacy in experimental autoimmune encephalomyelitis. Target: LPL Receptor. Smiles: CC=1C=C(C=C(C)C1C(N[C@H](C(O)=O)C)=O)C2=CC(N[C@H](C)C3=CC(C)=C(Cl)C=C3)=CC=C2. References: Bigaud M, Dincer Z, Bollbuck B, Dawson J, Beckmann N, Beerli C,...
| Keywords: | NIBR 0213 |
| Application: | S1PR1 antagonist |
| CAS | 1233332-14-3 |
| MW: | 464.98 D |
From 39.00€
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W140 (trifluoroacetate salt)
Item number: TGM-T38336-1mg
Description: Sphingosine-1-phosphate (S1P) is a bioactive lipid that exhibits a broad spectrum of biological activities including cell proliferation, survival, migration, cytoskeletal organization, and morphogenesis. It exerts its activity by binding to five distinct G protein-coupled receptors, S1P1/EDG-1,...
| Keywords: | W140 (trifluoroacetate salt) |
| Application: | S1P1 Antagonist Control |
| CAS | 909725-64-0 |
| MW: | 456.399 D |
From 190.00€
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CAY10734
Item number: TGM-T38371-10mg
Description: CAY10734 has a wide range of applications in life science related research. Target: Others. Smiles: CC(C)Cc1ccc(cc1)-c1nc(no1)-c1ccc(CN2CC(C2)C(O)=O)cc1
| Application: | S1P1 receptor agonist |
| CAS | 635701-59-6 |
| MW: | 391.471 D |
From 77.00€
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D-erythro/L-threo Lysosphingomyelin (d18:1)
Item number: TGM-T37187-10mg
Description: Lysosphingomyelin is an endogenous bioactive sphingolipid and a constituent of lipoproteins.1,2It is produced by the removal of the acyl group from sphingomyelin by a deacylase and acts as a precursor in the biosynthesis of sphingosine-1-phosphate . D-erythroLysosphingomyelin is an agonist of the S1P...
| Keywords: | D-erythro/L-threo Lysosphingomyelin (d18:1) |
| Application: | Bioactive sphingolipid mixture |
| CAS | 82970-80-7 |
| MW: | 464.628 D |
From 239.00€
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Sphingosine-1-phosphate (d16:1)
Item number: TGM-T37955-1mg
Description: C16 Sphingosine-1-phosphate (C16 S1P) is a derivative of sphingosine-1-phosphate that binds to S1P1/EDG-1, S1P3/EDG-3, and S1P2/EDG-5 receptors with affinities of 115%, 83%, and 103%, respectively, relative to S1P in CHO cells. C16 S1P was increased in postmortem primary open angle glaucoma trabecular...
| Keywords: | Sphingosine-1-phosphate (d16:1) |
| Application: | S1PR1/S1PR2/S1PR3 ligand |
| CAS | 709026-60-8 |
| MW: | 351.424 D |
From 482.00€
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Sphinganine 1-phosphate
Item number: TGM-T39401-1mg
Description: Sphinganine 1-phosphate, also known as D-erythro-Dihydrosphingosine 1-phosphate, is a polar sphingolipid metabolite. It plays a crucial role in regulating various cellular processes including cell migration, differentiation, survival, and complex physiological processes. Target: Others. Smiles:...
| Keywords: | Sphinganine 1-phosphate, D-erythro-Dihydrosphingosine 1-phosphate |
| Application: | Metabolic glycosphingolipid / sphingolipid intermediate, EDG1 antagonist |
| CAS | 19794-97-9 |
| MW: | 381.49 D |
From 151.00€
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L-threo Lysosphingomyelin (d18:1)
Item number: TGM-T38452-5mg
Description: L-threo Lysosphingomyelin (d18:1) (L-threo-Sphingosylphosphorylcholine) is a naturally occurring bioactive sphingolipid that functions as a potent agonist for S1P receptors, with EC50 values of 19.3, 131.8, and 313.3 nM for hS1P1, hS1P3, and hS1P2, respectively. Target: Others. Smiles:...
| Keywords: | L-threo Lysosphingomyelin (d18:1), L-threo-Sphingosylphosphorylcholine |
| Application: | Endogenous bioactive sphingolipid, sphingosine-1-phosphate (S1P) receptor agonist |
| CAS | 105615-55-2 |
| MW: | 464.62 D |
1,039.00€
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TASP 0277308
Item number: TGM-T41145-5mg
Description: TASP 0277308 is a potent and selective sphingosine 1-phosphate 1 (S1P1) receptor antagonist (IC50 = 7.8 nM). TASP 0277308 inhibits S1P-induced chemotaxis (IC50 = 1.1-1.6 nM), HUVEC cell proliferation (IC50 = 3-3.6 nM) and suppresses angiogenesisin vivo. TASP 0277308 also blocks VEGF-induced...
| Application: | S1P1 antagonist |
| CAS | 945725-50-8 |
| MW: | 539.48 D |
777.00€
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