22 products were found matching "K04216"!

Description: JTC-801 is a selective opioid receptor-like 1 (ORL1) receptor antagonist with an IC50 of 94 nM and weak inhibitory effects on delta, kappa, and µ receptors. Target: Opioid Receptor. Smiles: Cl.CCc1ccc(OCc2ccccc2C(=O)Nc2ccc3nc(C)cc(N)c3c2)cc1. References: Yamada H, et al. Br J Pharmacol, 2002, 135(2),...

Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: OPRL1. Antigen Species: Human

Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: OPRL1. Antigen Species: Human

AT-121 is a dual µ-opioid and nociceptin receptor partial agonist (Kis = 16.49 and 3.67 nM, respectively). It stimulates [35S]GTPgammaS binding to cell membranes expressing µ-opioid or nociceptin receptors (EC50s = 19.6 and 34.7 nM, respectively). AT-121 (0.003-0.03 mg/kg) decreases capsaicin-induced thermal...

Nociceptin is a 17 amino acid neuropeptide involved in a variety of biological systems including pain, memory, stress responses, anxiety, locomotion, and feeding behavior. It is an endogenous ligand of the NOP1 (ORL1) receptor (Ki = 88 µM in CHO cells) and, though an opioid-related peptide, does not interact...

JTC 801 is an antagonist of the nociceptin receptor (ORL1, Ki = 44.5 nM, IC50 = 94 nM) that is >100-, >100-, and >3-fold more selective for ORL1 over the related delta-, kappa-, and µ-opioid receptors, respectively. It demonstrates anti-nociceptive effects in acute pain models in mice upon oral administration at 1...

Cebranopadol is an agonist of nociceptin-, µ-, ?-, and delta-opioid receptors (Kis = 0.9, 0.7, 2.6, and 18 nM, respectively). It is greater than 100-fold selective for these receptors over a panel of more than 100 ion channels, neurotransmitter transporters, receptors, and enzymes, but does bind to the serotonin...

The protein encoded by this gene is a G protein-coupled receptor whose expression can be induced by phytohemagglutinin. The encoded integral membrane protein is a receptor for the 17 aa neuropeptide nociceptin/orphanin FQ. This gene may be involved in the regulation of numerous brain activities, particularly...

Protein function: G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G...

BAN ORL 24 is an antagonist of the nociceptin (NOP) receptor (Ki = 0.24 nM in a radioligand binding assay using CHO cell membranes expressing the human receptor). It is selective for NOP receptors over µ-, delta-, and kappa-opioid receptors (Kis = 0.19, 0.34, and >1 µM, respectively). BAN ORL 24 reduces NOP-induced...

6beta-Naltrexol-d3 (Cay-18350) is an analytical reference material intended for use as an internal standard for the quantification of 6beta-naltrexol (Cay-15896) by GC- or LC-MS. 6beta-Naltrexol is the major metabolite of naltrexone (Cay-ISO60192, Cay-15520). It is a neutral µ-opioid receptor antagonist (Ki = 94...