60 products were found matching "K04214"!

Aticaprant is a kappa-opioid receptor (KOR) antagonist (Ki = 0.807 nM). It is selective for KOR over the µ- and delta-opioid receptors (Kis = 24 and 155 nM, respectively). Aticaprant reverses U-69593-induced decreases in nocifensive behavior in the formalin test in rats (ED50 = 0.4 mg/kg). It also reverses...

Description: Akuammine is an antimalarial indolemonoterpene alkaloid from Picralima nitida seeds. Target: Others. Smiles: C(OC)(=O)[C@@]12[C@]34[C@]([C@]5(N(CC3)C\C(=C\C)\[C@@]1(C5)[H])[H])(N(C)C=6C4=CC(O)=CC6)OC2. References: Moreno J, Picazo E, Morrill LA, Smith JM, Garg NK. Enantioselective Total Syntheses of...

Description: Asimadoline (EMD-61753) is a proprietary small molecule therapeutic, originally discovered by Merck KGaA of Darmstadt, Germany. Asimadoline was originally developed to treat peripheral pain such as arthritis. Asimadoline is an orally administered agent that acts as a kappa opioid receptor agonist. It...

Description: Cyclazocine is an analgesic with mixed narcotic agonist-antagonist properties. Target: Others. Smiles: CC12C=3C(CC(C1C)N(CC4CC4)CC2)=CC=C(O)C3

Description: LY2795050 is a novel specific kappa-Opioid Receptor antagonist (IC50: 0.72 nM). Target: Opioid Receptor. Smiles: NC(=O)c1ccc(Oc2ccc(CN3CCC[C@H]3c3cccnc3)cc2)c(Cl)c1. References: Mitch, Charles H., Quimby, Steven J., Diaz, Nuria, et al. Discovery of Aminobenzyloxyarylamides as kappa Opioid Receptor...

Description: Aticaprant (LY-2456302) (CERC-501) is a potent and centrally-penetrant antagonist of the kappa-opioid receptor (Ki: 0.807 nM). Target: Opioid Receptor. Smiles: Cc1cc(C)cc(c1)[C@@H]1CCCN1Cc1ccc(Oc2ccc(cc2F)C(N)=O)cc1. References: Rorick-Kehn LM, et al. LY2456302 is a novel, potent, orally-bioavailable...

Description: Oxilorphan acts as a µ-opioid receptor (MOR) antagonist but a kappa-opioid receptor (KOR) partial agonist and has similar effects to naloxone and around the same potency as a MOR antagonist. Oxilorphan has some weak partial agonist actions at the MOR and can produce hallucinogenic/dissociative effects...

Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific...

Salvinorin B (Cay-23582) is an analytical reference standard categorized as a diterpene. Salvinorin B is a presumptive metabolite of salvinorin A (Cay-38208, Cay-11487). It has been found in S. divinorum, a plant with hallucinogenic properties. This product is intended for research and forensic applications.Formal...

Fedotozine is a kappa-opioid receptor agonist. It binds to kappa-opioid receptors in mouse brain membranes (Ki = 0.16 nM). In vivo, fedotozine (10 mg/kg) reduces gastric extension-induced increases in mean arterial pressure (MAP), a marker for hyperalgesia, in a rat model of duodenal acidification-induced gastric...

beta-Funaltrexamine is an irreversible µ- and kappa1-opioid receptor antagonist (Kis = 0.3 and 0.2 nM, respectively). It is selective for µ- and kappa1-opioid receptors over the delta-opioid receptor (Ki = 12.8 nM). beta-Funaltrexamine also reversibly inhibits electricity-induced twitches of isolated guinea pig...

Nalfurafine (Cay-23186) is an analytical reference standard categorized as an opioid. Naflurafine decreases ethanol consumption in male mice and increases ethanol consumption in female mice. It is regulated as a Schedule II compound in the United States. This product is intended for research and forensic...