38 products were found matching "K04202"!

Ac-(D-Arg)-CEH-(D-Phe)-RWC-NH2 is a cyclic peptide and an agonist of melanocortin receptor 4 (MC4R). It induces cAMP release in HEK293 cells expressing human MC4R (EC50 = 0.28 nM). Ac-(D-Arg)-CEH-(D-Phe)-RWC-NH2 is selective for MC4R over MC1R, MC3R, and MC5R (Kis = 0.55, 16.78, 56.79, and >500 nM, respectively). It...

SNT-207707 is a melanocortin receptor 4 (MC4R) antagonist (IC50 = 5 nM). It increases food intake in mice when administered at a dose of 20 mg/kg. SNT-207707 (30 mg/kg per day) inhibits tumor-induced weight loss without inhibiting tumor growth in a C26 murine colon carcinoma model of tumor-induced cachexia.Formal...

MCL0020 is a melanocortin receptor 4 (MC4R) antagonist. It selectively inhibits [Nle4,D-Phe7]-alpha-MSH (Cay-24475) binding to recombinant human MC4R over MC1R and MC3R (IC50s = 11.63, >10,000, and 1,115 nM, respectively). MCL0020 (0.1-100 µM) inhibits alpha-MSH-induced cAMP production in COS-1 cells expressing...

HS-014 is an antagonist of melanocortin receptor 4 (MC4R, Ki = 3.16 nM). It is selective for MC4R over MC1R, MC3R, and MC5R (Kis = 108, 54.4, and 694 nM, respectively). HS-014 inhibits cAMP accumulation induced by alpha-melanocyte-stimulating hormone (alpha-MSH) in COS-1 cells expressing MC4R in a...

HS-024 is a cyclic peptide antagonist of melanocortin receptor 4 (MC4R, Ki = 0.29 nM). It is selective for MC4R over MC1R, MC3R, and MC5R (Kis = 18.6, 5.45, and 3.29 nM, respectively). HS-024 (100 nM) inhibits cAMP accumulation induced by alpha-melanocyte-stimulating hormone (alpha-MSH, Cay-29923) in COS-1 cells...

RO27-3225 is a peptide agonist of melanocortin receptor 4 (MC4R). It selectively induces cAMP production in cells expressing human MC4R (EC50 = 0.3 nM) over cells expressing MC1R, MC3R, or MC5R (EC50s = 1.1, 97.9, and 139.4 nM, respectively). In vivo, RO27-3225 (3, 5, and 10 nmol/animal) reduces food intake in rats,...

PF-00446687 is an agonist of melanocortin receptor 4 (MC4R). It selectively activates adenylyl cyclase in HEK293 cells expressing MC4R (EC50 = 0.012 µM) over HEK293 cells expressing MC1R, MC3R, or MC5R (EC50s = 1.02, 1.16, and 1.98 µM, respectively). PF-00446687 (1 mg/kg per day) increases time spent huddling and in...

Description: SHU 9119 is an effective human melanocortin 3 and 4 receptors (MC3/4R) antagonist and a partial MC5R agonist (IC50: 0.23, 0.06, and 0.09 nM for human MC3R, MC4R and MC5R, respectively). Target: Others. Smiles:...

Description: THIQ is a selective melanocortin-4 receptor (MC4R) agonist (hMC4R and rMC4R with IC50 of 1.2 nM and 0.6 nM , respectively). Target: Melanocortin Receptor. Smiles: ClC1=CC=C(C[C@@H](NC(=O)[C@H]2CC3=CC=CC=C3CN2)C(=O)N2CCC(CN3C=NC=N3)(CC2)C2CCCCC2)C=C1. References: Huang H, et al. A small molecule agonist...

Organism: Mus musculus (Mouse). Source: in vitro E.coli expression system. Expression Region: 1-332aa. Protein Length: Full Length. Tag Info: N-terminal 10xHis-tagged. Target Protein Sequence: MNSTHHHGMY TSLHLWNRSS YGLHGNASES LGKGHPDGGC YEQLFVSPEV FVTLGVISLL ENILVIVAIA KNKNLHSPMY FFICSLAVAD MLVSVSNGSE TIVITLLNST...

Recombinant human MC4R Protein with C-terminal human Fc tag. MC4R(Met1-Gln43) hFc(Glu99-Ala330), Protein function: Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is...

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