51 products were found matching "K04146"!

U-99194 is a dopamine D3 receptor antagonist (Ki = 160 nM for the human receptor). It is selective for dopamine D3 receptors over the alpha1-adrenergic receptor (alpha1-AR, Ki = 8,913 nM for the rat receptor), M1 muscarinic acetylcholine receptor (mAChR), serotonin (5-HT) receptor subtype 5-HT1A, and dopamine D4...

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human DRD3. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human DRD3. Next,...

Pimozide is a dopamine receptor antagonist (Kis = 2.4, 0.3, and 1.8 nM for D2, D3, and D4 receptors, respectively). It also binds to eight additional receptors (Kds = 25-3,100 nM for the human receptors) and inhibits the voltage-gated sodium channel Nav1.2 and the voltage-gated potassium channel Kv11.1 (IC50s = 42...

Fluspirilene is a dopamine D2 and D3 receptor antagonist (Kis = 1.5 and 1.1 nM, respectively). It is selective for dopamine D2 and D3 receptors over dopamine D1, alpha1- and alpha2-adrenergic, H1 histamine, and sigma-1 (sigma1) receptors (Kis = 450, 102, >5,000, 540, and 150 nM, respectively), muscarinic...

Amisulpride is a dopamine D2 and D3 receptor antagonist (Kis = 3 and 3.5 nM, respectively). It is also an antagonist of the serotonin (5-HT) receptor subtypes 5-HT2B, 5-HT7, and 5-HT7A (Kis = 13, 11.5, and 135.5 nM, respectively). It is selective for these receptors over a panel of 39 additional receptors, ion...

Is a medication for treating Parkinsons disease and restless leg syndrome. A non-ergoline dopamine agonist.

SB 277011A is an antagonist of the dopamine D3 receptor (pKi = 8.0) that is at least 100-fold selective for D3 over other monoamine receptors (pKis = 6.0, 5.0, and 2, 5-HT1D and 5-HT1B respectively). It has high oral bioavailability and enters the central nervous system of the rat. SB 277011A has been shown to have...

PG-01037 is a selective dopamine D3 receptor antagonist (Kis = 0.7, 93, and 375 nM for HEK293 cells expressing human D3, D2, and D4 receptors, respectively). It inhibits quinpirole-induced stimulation of mitogenesis in CHO cells expressing human dopamine D3 receptors (EC50 = 3 nM). PG-01037 (32 mg/kg) reduces...

Dopamine is an endogenous catecholamine neurotransmitter synthesized from the amino acid L-tyrosine that acts as an agonist at dopamine receptors (D1-5). Dopamine is mainly synthesized in the substantia nigra and ventral tegmental area, and is a precursor in norepinephrine and epinephrine biosynthesis....

Sulpiride is an antipsychotic that functions as an antagonist at D2/3 receptors and also upregulates and activates the GHB receptor. In vivo, sulpiride ameliorates increased impulsivity and attentional impairment in PFC-lesioned models of schizophrenia. Additionally, because dopamine inhibits prolactin release,...

0.5mg/ml if reconstituted with 0.2ml sterile DI water. DRD3 is a dopamine receptor that differs in its pharmacology and signaling system from the D1 and D2 receptors and represents both an autoreceptor and a postsynaptic receptor. DRD3 is localized to limbic areas of the brain, which are associated with cognitive,...

NGB 2904 is an antagonist that is selective for the dopamine D3 receptor (Ki = 1.4 nM). It potently inhibits quinpirole-stimulated mitogenesis (IC50 = 6.8 nM). NGB 2904 attenuates cocaine- and stress-induced reinstatement of drug-seeking behavior in rats. It also increases spontaneous and amphetamine-stimulated...