64 products were found matching "K04139"!

Moxonidine is an imidazoline 1 (I1) receptor agonist (Ki = 56 nM in a radioligand binding assay). It is also an agonist of the alpha2A-adrenergic receptor (alpha2A-AR, Ki = 150 nM in a radioligand binding assay). It is selective for I1 and alpha2A-AR receptors over alpha1-, alpha2B, and alpha2C-ARs (Kis = >30,000,...

Description: Azepexole dihydrochloride (B-HT 933), a potent and selective alpha 2-adrenoceptor agonist, exhibits affinity for alpha2A-, alpha2B-, and alpha2C-adrenoceptor subtypes with pKis of 8.3, 7.6, and 7.5, respectively [1]. It elicits a concentration-dependent inhibition of peristaltic contractions, evidenced...

Description: Methyldopate is an ethyl ester prodrug form of methyldopa , a dopamine decarboxylase inhibitor that has antihypertensive activity in vitro and in vivo., Formulations containing methyldopate have been used in the treatment of hypertension. Target: Others. Smiles: CCOC(=O)[C@@](C)(N)Cc1ccc(O)c(O)c1

Description: Piperoxan hydrochloride (Benodaine hydrochloride) is an alpha2 adrenoceptor antagonist. Piperoxan (benodaine) is a drug which was the very first antihistamine to be discovered. Target: Adrenergic Receptor. Smiles: Cl.C(C1COc2ccccc2O1)N1CCCCC1. References: Viemari JC, et al. Nasal trigeminal inputs...

Apraclonidine is an alpha2-adrenergic receptor (alpha2-AR) agonist and structural analog of clonidine (Cay-15949). It binds to alpha2-ARs in calf cortex, rat kidney, and rat spleen with IC50 values of 0.9, 4.3, and 4.2 nM, respectively. Apraclonidine also binds to alpha2-ARs in rat cerebral cortex, pig submandibular...

Description: 2-(1-Piperazinyl)pyrimidine is used as an anti-anxiety drug. Target: Adrenergic Receptor. Smiles: C1CN(CCN1)C1=NC=CC=N1. References: Rajamani T, Muthu S. Spectrochim Acta A Mol Biomol Spectrosc. 2013 Nov,115:654-66.

Host Species: Rabbit. Isotype: IgG. Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by...

Romifidine is an alpha2-adrenergic receptor (alpha2-AR) agonist. Epidural administration of romifidine (50 µg/kg) induces antinociception and sedation in donkeys. It also induces bradycardia in horses when administered at doses ranging from 0.04 to 0.12 mg/kg. Formulations containing romifidine have been used as...

Dexmedetomidine is an agonist of alpha2-adrenergic receptors (alpha2-ARs). It selectively binds to alpha2-ARs over alpha1-ARs (Kis = 0.015 and 5 nM, respectively). In vivo, dexmedetomidine (50 µg/kg) prevents increases in cardiac troponin I (CTnI), a marker of myocardial injury, as well as reduces myocardial...

In 1X PBS, pH 7.4, with 0.09% sodium azide. Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from...

Levonordefrin is the (-)-enantiomer of nordefrin, a synthetic derivative of norepinephrine (Cay-16673), that acts as a vasoconstrictor. Levonordefrin (1-5 µg/kg) rapidly increases blood pressure and heart rate in anesthetized dogs and has a more potent effect on blood pressure than the dextronordefrin enantiomer. It...

Medetomidine is an agonist of alpha2-adrenergic receptors (alpha2-ARs, Ki = 1.08 nM). It is selective for alpha2-ARs over alpha1-ARs (Ki = 1,750 nM). Medetomidine induces sedation in dogs. Formulations containing medetomidine have been used as sedatives in veterinary medicine. This product is also available as an...