33 products were found matching "K04132"!

Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific...

Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: CHRM4. Antigen Species: Human

Metixene is an antagonist of muscarinic acetylcholine receptors (mAChRs, Ki = 15 nM for the rat receptor). It also inhibits bovine acetylcholinesterase (AChE) by 43% when used at the concentration 10 µM and butyrylcholinesterase (BChE, IC50 = 1.6 µM for the horse enzyme) in cell-free assays. Metixene reduces the...

Trospium is an antagonist of muscarinic (M) receptors (Kis = 0.50-2.3 nM for human M1-5 recombinant receptors, respectively). Formulations containing antimuscarinics, including trospium, are used to manage overactive bladder by relieving urgency, frequency, and incontinence.Formal Name:...

An antispasmodic agent.

Aclidinium is an antagonist of muscarinic acetylcholine receptors (mAChRs, Kis = 0.1, 0.14, 0.14, 0.21, and 0.16 for the M1-M5 receptors, respectively). It induces relaxation of precontracted isolated human bronchi when used at a concentration of 0.1 µM. Aclidinium reduces bronchoconstriction induced by ACh...

Bethanechol is an agonist of muscarinic acetylcholine receptors with IC50 values of 1,837, 25, 631, 317, and 393 µM for M1-5, respectively, in a radioligand binding assay using CHO cells expressing the human receptors. It inhibits M2-mediated increases in cyclic AMP induced by isoproterenol (Cay-15592) in isolated...

Oxybutynin is an antagonist of muscarinic acetylcholine receptors (Kis = 5, 14.5, 3.7, 5.3, and 40 nM for human recombinant M1-5, respectively). It inhibits intracellular calcium mobilization induced by carbamoylcholine (carbachol, Cay-14486) in bladder smooth muscle and submandibular gland cells isolated from...

Cyclopentolate is an antagonist of muscarinic acetylcholine receptors (Kis = 1.62, 27.5, and 2.63 nM for M1, M2, and M3 receptors, respectively). It inhibits carbachol-induced contraction of isolated human iris sphincter, circular ciliary muscle, and longitudinal ciliary muscle (Kbs = 7.9, 15.8, and 12.5 nM,...

Muscarinic receptors are G protein-coupled acetylcholine receptors that play diverse roles. Five subtypes (M1-5) have been identified, which preferentially couple to various effector systems based on their G protein interaction.Tropicamide is a muscarinic acetylcholine receptor (mAChR) antagonist (pKi = 7.2 in...

Atropine is a naturally occurring tropane alkaloid isolated from plants in the Solanaceae family. Atropine is an anticholinergic compound that also exhibits analgesic and antinociceptive activities. Atropine is a competitive inhibitor of muscarinic acetylcholine receptors (mAChRs) that is commonly used for...

A specific muscarinic (M4) antagonist.