39 products were found matching "K04132"!

Description: Emraclidine (CVL-231), a muscarinic M4 receptor positive allosteric modulator, is utilized in studies of neurological diseases. Target: AChR. Smiles: Cc1cc(C)c2CN(Cc2n1)C(=O)CC1CN(C1)c1ccnc(c1)C(F)(F)F. References: Lei Zhang, et al. 5,7-dihydro-pyrrolo-pyridine derivatives for treating neurological and...

Description: Iperoxo (Iperoxo iodide) is an agonist of Muscarinic AChR and can be used to probe activation-related conformational transitions of muscarinic receptors. Target: AChR. Smiles: [I-].C[N+](C)(C)CC#CCOC1=NOCC1. References: Jiménez-Rosés M, et al. Ligand-Triggered Structural Changes in the M(2) Muscarinic...

Description: LY2119620 is a specific, and allosteric agonist of human M2 and M4 muscarinic acetylcholine receptors. Target: AChR. Smiles: CN1CCN(CC1)C(=O)COc1nc2sc(C(=O)NC3CC3)c(N)c2c(C)c1Cl. References: Croy CH, et al. Mol Pharmacol. 2014, 86(1), 106-115.

Description: VU0152100 is an effective and selective allosteric potentiator of M4 mAChR (EC50: 380 ± 93 nM). Target: AChR. Smiles: COc1ccc(CNC(=O)c2sc3nc(C)cc(C)c3c2N)cc1. References: Brady AE, et al. Centrally active allosteric potentiators of the M4 muscarinic acetylcholine receptor reverse amphetamine-induced...

Description: VU0467154 is a positive allosteric modulator of the M4 muscarinic acetylcholine receptor (M4 mAChR). Target: AChR. Smiles: NC=1C=2C(SC1C(NCC3=CC=C(S(C(F)(F)F)(=O)=O)C=C3)=O)=NN=C(C)C2C. References: Bubser M, et al. Selective activation of M4 muscarinic acetylcholine receptors reverses MK-801-induced...

Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific...

Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: CHRM4. Antigen Species: Human

Metixene is an antagonist of muscarinic acetylcholine receptors (mAChRs, Ki = 15 nM for the rat receptor). It also inhibits bovine acetylcholinesterase (AChE) by 43% when used at the concentration 10 µM and butyrylcholinesterase (BChE, IC50 = 1.6 µM for the horse enzyme) in cell-free assays. Metixene reduces the...

Trospium is an antagonist of muscarinic (M) receptors (Kis = 0.50-2.3 nM for human M1-5 recombinant receptors, respectively). Formulations containing antimuscarinics, including trospium, are used to manage overactive bladder by relieving urgency, frequency, and incontinence.Formal Name:...

An antispasmodic agent.

Aclidinium is an antagonist of muscarinic acetylcholine receptors (mAChRs, Kis = 0.1, 0.14, 0.14, 0.21, and 0.16 for the M1-M5 receptors, respectively). It induces relaxation of precontracted isolated human bronchi when used at a concentration of 0.1 µM. Aclidinium reduces bronchoconstriction induced by ACh...

McNA343 is a partial agonist of muscarinic acetylcholine receptors (Kis = 5, 1, 5, 0.2, and 7.6 µM for M1-5 receptors, respectively, in radioligand binding assays). It induces contraction of isolated human umbilical veins (EC50 = 1.23 µM), an effect that can be reversed by various M1 muscarinic receptor selective...