- Search results for K04130
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90 products were found matching "K04130"!
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Item number: CSB-EP005382HU1.1
Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 210-387aa. Protein Length: Partial. Tag Info: N-terminal 6xHis-tagged. Target Protein Sequence: SRASKSRIKK DKKEPVANQD PVSPSLVQGR IVKPNNNNMP SSDDGLEHNK IQNGKAPRDP VTENCVQGEE KESSNDSTSV SAVASNMRDD EITQDENTVS TSLGHSKDEN SKQTCIRIGT KTPKSDSCTP TNTTVEVVGS...
Keywords: | CHRM2, Muscarinic acetylcholine receptor M2, Recombinant Human Muscarinic acetylcholine receptor M2 (CHRM2), partial |
Application: | Activity not tested |
Expressed in: | E.coli |
Origin: | human |
MW: | 23.4 kD |
From 283.00€
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Item number: Cay39825-1
Metixene is an antagonist of muscarinic acetylcholine receptors (mAChRs, Ki = 15 nM for the rat receptor). It also inhibits bovine acetylcholinesterase (AChE) by 43% when used at the concentration 10 µM and butyrylcholinesterase (BChE, IC50 = 1.6 µM for the horse enzyme) in cell-free assays. Metixene reduces the...
Keywords: | Methixine, 1-methyl-3-(9H-thioxanthen-9-ylmethyl)-piperidine, monohydrochloride, monohydrate |
Application: | Muscarinic acetylcholine receptor antagonist |
CAS | 7081-40-5 |
MW: | 363.9 D |
From 34.00€
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Item number: Cay23609-500
Propantheline is an anticholinergic agent. It inhibits contraction of isolated guinea pig ileum induced by acetylcholine (Cay-23829) and reduces intensity of vagal-stimulated gastric contractions in rats. Propantheline (5 mg/kg, s.c.) increases gastric pH and prevents pyloric ligature-induced gastric ulcer formation...
Keywords: | SC-3171, N-methyl-N-(1-methylethyl)-N-[2-[(9H-xanthen-9-ylcarbonyl)oxy]ethyl]-2-propanaminium, monobromide |
Application: | Muscarinic acetylcholine receptor antagonist |
CAS | 50-34-0 |
MW: | 448.4 D |
From 35.00€
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Item number: Cay12008-1
Atropine is a naturally occurring tropane alkaloid extracted from plants of the family Solanaceae including deadly nightshade (A. belladonna). It is a non-selective, competitive antagonist of the muscarinic acetylcholine receptor types M1, M2, M3, M4, and M5 (pKBs range from 8.9-9.8). Atropine increases firing of...
Keywords: | DL-Hyoscyamine, Tropine tropate, alpha-(hydroxymethyl)-(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester-benzeneacetic acid |
Application: | Muscarinic acetylcholine receptor antagonist |
CAS | 51-55-8 |
MW: | 289.4 D |
From 34.00€
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Item number: Cay14487-500
(+)-Pilocarpine is a muscarinic acetylcholine receptor agonist that binds to human hippocampal, pons, and submandibular gland membranes, which are endogenously enriched in the M1, M2, and M3 receptor subtypes, respectively (apparent Kis = 6, 8.2, and 6.9 µM, respectively). It induces salivary secretion in rats when...
Keywords: | NSC 5746, (3S,4R)-3-ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-2(3H)-furanone, monohydrochloride |
Application: | Muscarinic acetylcholine receptor agonist |
CAS | 54-71-7 |
MW: | 244.7 D |
From 50.00€
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Item number: Cay20847-50
Oxotremorine M is a non-selective muscarinic (M) acetylcholine receptor agonist that induces phosphoinositide hydrolysis in mouse ileum isolated from wild-type, M2, M3, and M2/M3 knockout mice (EC50s = 0.36, 0.52, 1.62, and 1.48 µM, respectively). It also increases M4-induced inhibition of calcium currents in...
Keywords: | N,N,N-trimethyl-4-(2-oxo-1-pyrrolidinyl)-2-butyn-1-aminium, monoiodide |
Application: | Muscarinic receptor agonist |
CAS | 3854-04-4 |
MW: | 322.2 D |
From 97.00€
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Item number: Cay23830-1
Bethanechol is an agonist of muscarinic acetylcholine receptors with IC50 values of 1,837, 25, 631, 317, and 393 µM for M1-5, respectively, in a radioligand binding assay using CHO cells expressing the human receptors. It inhibits M2-mediated increases in cyclic AMP induced by isoproterenol (Cay-15592) in isolated...
Keywords: | (±)-Bethanechol, Carbamyl-beta-methylcholine chloride, NSC 30783, 2-[(aminocarbonyl)oxy]-N,N,N-trimethyl-1-propanaminium,... |
Application: | Muscarinic acetylcholine receptor agonist |
CAS | 590-63-6 |
MW: | 196.7 D |
From 50.00€
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Item number: Cay23825-1
Oxybutynin is an antagonist of muscarinic acetylcholine receptors (Kis = 5, 14.5, 3.7, 5.3, and 40 nM for human recombinant M1-5, respectively). It inhibits intracellular calcium mobilization induced by carbamoylcholine (carbachol, Cay-14486) in bladder smooth muscle and submandibular gland cells isolated from...
Keywords: | MJ4309-1, 4-(diethylamino)-2-butyn-1-yl ester alpha-cyclohexyl-alpha-hydroxy-benzeneacetic acid, monohydrochloride |
Application: | Muscarinic cholinergic receptor antagonist |
CAS | 1508-65-2 |
MW: | 394 D |
From 98.00€
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Item number: Cay24317-10
Methoctramine is a selective antagonist of M2 muscarinic acetylcholine receptors (IC50 = 6.1 nM in CHO-K1 cell membranes). It is selective for M2 over M1, M3, M4, and M5 receptors (IC50s = 92, 770, 260, and 217 nM, respectively). In vitro, methoctramine inhibits acetylcholine-induced reductions in isolated guinea...
Keywords: | N1,N8-bis[6-[[(2-methoxyphenyl)methyl]amino]hexyl]-1,8-octanediamine, tetrahydrochloride, hydrate |
Application: | Selective M2 muscarinic acetylcholine receptor antagonist |
MW: | 728.8 D |
From 156.00€
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Item number: Cay23867-500
Dicyclomine is an M1 and M2 muscarinic acetylcholine receptor antagonist (Kis = 3.16 and 44.7 nM, respectively). It inhibits inositol phosphate accumulation induced by the non-selective acetylcholine agonist carbamoylcholine (carbachol, Cay-14486) in guinea pig cortex (Ki = 12 nM, pA2 = 7.88). Dicyclomine (10 mg/kg,...
Keywords: | Dicycloverine, [1,1'-bicyclohexyl]-1-carboxylic acid, 2-(diethylamino)ethyl ester, monohydrochloride |
Application: | Muscarinic acetylcholine receptor M1 / M2 antagonist |
CAS | 67-92-5 |
MW: | 346 D |
From 27.00€
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Item number: Cay20700-10
Umeclidinium is an antagonist of muscarinic acetylcholine receptors (Kis = 0.05-0.16 nM for M1-M5 human recombinant receptors). It inhibits acetylcholine-induced activation of recombinant M3 receptors in CHO cell membranes (IC50 = 50 = 10 µM) and bronchoconstriction in mice when administered intranasally (ED50 =...
Keywords: | GSK573719, 4-(hydroxydiphenylmethyl)-1-[2-(phenylmethoxy)ethyl]-1-azoniabicyclo[2.2.2]octane, monobromide |
Application: | Muscarinic acetylcholine receptor antagonist |
CAS | 869113-09-7 |
MW: | 508.5 D |
From 163.00€
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Item number: Cay26373-5
LY2119620 is a positive allosteric modulator of the M2 and M4 muscarinic acetylcholine receptors (mAChRs). It binds to allosteric sites on M2 and M4 receptors with KB values ranging from 1.8 to 3.4 µM. LY2119620 potentiates the activity of the AChR agonist acetylcholine (ACh, Cay-23829) and the mAChR agonists...
Keywords: | 3-amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methyl-1-piperazinyl)-2-oxoethoxy]-thieno[2,3-b]pyridine-2-carboxamide |
Application: | Muscarinic acetylcholine receptor M2 / M4 positive allosteric modulator (PAM) |
CAS | 886047-22-9 |
MW: | 437.9 D |
From 98.00€
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