29 products were found matching "K03915"!

Description: SSR240612 is a potent, orally active, specific non-peptide bradykinin B1 receptor antagonist (Kis = 0.48-0.73 nM for B1 receptors and 358-481 nM for B2 receptors, respectively). Target: Bradykinin Receptor. Smiles:...

R 715 is a bradykinin B1 receptor antagonist. It inhibits contractions induced by bradykinin (Cay-37408) in isolated human umbilical cords, which express bradykinin B1 receptors (pA2 = 8.49). R 715 (200, 400, and 600 µg/kg) decreases the latency to tail withdrawal in the tail-flick test in a mouse model of diabetic...

Description: SCH79797 dihydrochloride is an effective and selective antagonist of protease activated receptor 1 (PAR1) with an IC50 of 70 nM and a Ki of 35 nM. SCH79797 dihydrochloride has antiproliferative and pro-apoptotic effects. Target: Protease-activated Receptor, Apoptosis, Others. Smiles:...

Description: Bradykinin (acetate) is an active peptide that is generated by the kallikrein-kinin system. It is a inflammatory mediator and also recognized as a neuromediator and regulator of several vascular and renal functions. Enzymatically produced from kallidin in the blood, it is a powerful vasodilator that...

SCH 79797 is a non-peptide antagonist of proteinase-activated receptor 1 (PAR1). It blocks binding of the high affinity thrombin receptor-activating peptide (haTRAP) (IC50 = 70 nM) as well as platelet aggregation induced by either haTRAP or alpha-thrombin (IC50 = 0.3 and 3 µM, respectively). SCH 79797 has no...

Protein function: This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation. [The UniProt Consortium]

0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide. Additional name(s) for this target protein: Bradykinin receptor B1 Protein function: This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation. [The UniProt Consortium]

Lys-(Des-Arg9)-Bradykinin is a naturally occurring peptide agonist of the bradykinin B1 receptor (Ki = 0.12 nM in HEK293 cells expressing the human receptor). It is selective for bradykinin B1 over B2 receptors (IC50 = >30,000 nM in CHO cells expressing the human receptor). Lys-(Des-Arg9)-Bradykinin increases both...

Lys-(Des-Arg9, Leu8)-Bradykinin is a bradykinin B1 receptor antagonist (Ki = 0.43 nM for the rabbit aorta receptor). It is selective for the bradykinin B1 over the B2 receptor (Ki = >10 µM for the rabbit ileum receptor). Lys-(Des-Arg9, Leu8)-Bradykinin inhibits contractions induced by the bradykinin B1 receptor...

SSR 240612 is a selective, non-peptide antagonist of the bradykinin B1 receptor (Kis = 0.48-0.73 and 358-481 nM for B1 and B2 receptors, respectively). It inhibits the contraction of rabbit aorta and rat ileum induced by the B1 receptor agonist des-Arg9-bradykinin (des-Arg9-BK) ex vivo in a concentration-dependent...

Protein function: This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation. [The UniProt Consortium]