79 products were found matching "K03871"!
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Anti-VHL
Item number: ATA-HPA068954.100
Polyclonal Antibody against Human VHL, Gene description: von Hippel-Lindau tumor suppressor, Alternative Gene Names: VHL1, Validated applications: IHC, Uniprot ID: P40337, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C. Protein function: Involved in the ubiquitination and...
| Keywords: | Anti-VHL, Anti-pVHL, Anti-Protein G7, Anti-von Hippel-Lindau disease tumor suppressor |
| Application: | IHC |
| Host: | Rabbit |
| Species reactivity: | human |
382.00€
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VH 032 amide C7 Acid
Item number: Cay40447-10
VH 032 amide C7 acid is a precursor in the synthesis of proteolysis-targeting chimeras (PROTACs) that contains a terminal carboxylic acid conjugated via a heptyl linker to VHL ligand 1 (Cay-21591), which binds to von Hippel-Lindau (VHL) E3 ligase. It has been used in the synthesis of PROTACs targeting anaplastic...
| Keywords: | N-(8-carboxy-1-oxooctyl)-3-methyl-L-valyl-4R-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-L-prolinamide |
| Application: | PROTAC precursor |
| CAS | 2172819-76-8 |
| MW: | 600.8 D |
From 108.00€
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LC-2
Item number: TGM-T36256-1mg
Description: LC-2 (PROTAC KRASG12C Degrader-LC-2) is a novel von Hippel-Lindau-based PROTAC degrader of endogenous KRAS G12C with a DC50 between 0.25 and 0.76 µM.LC-2 is a PROTAC that covalently binds KRAS G12C with MRTX849 and recruits the E3 ligase, VH, to induce a rapid and sustained degradation of KRAS G12C....
| Keywords: | PROTAC KRASG12C Degrader-LC-2, LC 2, LC2 |
| Application: | Protac(R) reagent |
| CAS | 2502156-03-6 |
| MW: | 1132.78 D |
From 261.00€
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(S,R,S)-AHPC-C6-NH2 hydrochloride
Item number: TGM-T39898-100mg
Description: (S, R, S)-AHPC-C6-NH2 hydrochloride (also known as VH032-C6-NH2 hydrochloride) is a synthetic E3 ligase ligand-linker conjugate. It combines the VH032-based VHL ligand with a linker designed for AKT PROTAC degrader applications. Target: Others. Smiles:...
| Keywords: | VH032-C6-NH2 hydrochloride, (S,R,S)-AHPC-C6-NH2 hydrochloride |
| Application: | Protac(R) reagent |
| CAS | 2360522-76-3 |
| MW: | 594.21 D |
Please request pricing for this article.
(S,R,S)-AHPC hydrochloride
Item number: TGM-T4207-100mg
Description: (S,R,S)-AHPC hydrochloride (Protein degrader 1 hydrochloride) is a building block in the synthesis of proteolysis-targeting chimera technologies (PROTACs). Target: Ligand for E3 Ligase, Others. Smiles: Cl.Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1. References: Buckley DL, et...
| Keywords: | VHL Ligand 1 hydrochloride, ULM-1, Protein degrader 1 hydrochloride |
| Application: | Protac(R) reagent |
| CAS | 1448189-80-7 |
| MW: | 467.03 D |
From 48.00€
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ARV-771
Item number: TGM-T5435-100mg
Description: ARV-771 is a potent BET degrader based on PROTAC technology, with Kds of 34 nM for BRD2(1), 4.7 nM for BRD2(2), 8.3 nM for BRD3(1), 7.6 nM for BRD3(2), 9.6 nM for BRD4(1), and 7.6 nM for BRD4(2), respectively[1]. Target: PROTACs, Epigenetic Reader Domain. Smiles:...
| Application: | Protac(R) reagent |
| CAS | 1949837-12-0 |
| MW: | 986.64 D |
From 55.00€
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MZ 1
Item number: TGM-T5436-100mg
Description: MZ 1 is a BRD4 protein degrader based on PROTAC technology. Target: Epigenetic Reader Domain, PROTACs. Smiles: CC=1C2=C(N3C([C@H](CC(NCCOCCOCCO CC(N[C@H](C(=O)N4[C@H](C(NCC5=CC=C(C=C5)C6=C(C)N=CS6)=O)C[C@@H](O)C4)C(C)(C)C)=O)=O)N=C2C7=CC=C(Cl)C=C7)=NN=C3C)SC1C. References: Gadd MS, et al. Structural...
| Application: | Protac(R) reagent |
| CAS | 1797406-69-9 |
| MW: | 1002.64 D |
From 46.00€
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(S,R,S)-AHPC-Me
Item number: TGM-T7752-100mg
Description: (S,R,S)-AHPC-Me (E3 ligase Ligand 1A) (VHL ligand 2) is an (S,R,S)-AHPC-based VHL ligand used to recruit the von Hippel-Lindau (VHL) protein. It is utilized in the synthesis of ARV-771, a VHL E3 ligase-based BET PROTAC degrader that effectively degrades BET proteins in castration-resistant prostate...
| Keywords: | E3 ligase Ligand 1A, VHL ligand 2 |
| Application: | Protac(R) reagent |
| CAS | 1948273-02-6 |
| MW: | 444.59 D |
From 40.00€
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(S,R,S)-AHPC-Boc
Item number: TGM-T77916-50mg
Description: (S,R,S)-AHPC-Boc (VH032-Boc) is a ligand for von Hippel-Lindau (VHL) protein recruitment in PROTAC technology [1]. Target: Others. Smiles: Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)OC(C)(C)C)C(C)(C)C)cc1
| Keywords: | VH032-Boc |
| Application: | Protac(R) reagent |
| CAS | 1448189-98-7 |
| MW: | 530.68 D |
Please request pricing for this article.
GMB-475
Item number: TGM-T8488-100mg
Description: GMB-475 is a BCR-ABL1 tyrosine kinase degrader based on PROTAC, overcoming BCR-ABL1-dependent drug resistance. GMB-475 targets BCR-ABL1 protein and recruits the E3 ligase Von Hippel Lindau (VHL).resulting in ubiquitination and subsequent degradation of the oncogenic fusion protein. Target: PROTACs,...
| Application: | Protac(R) reagent |
| CAS | 2490599-18-1 |
| MW: | 861.93 D |
From 88.00€
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VHL Protein, Human, Recombinant (His & Avi)
Item number: TGM-TMPY-06026-100ug
Description: VHL Protein, Human, Recombinant (His & Avi) is expressed in E. coli expression system with His and Avi tag. The predicted molecular weight is 27.5 kDa and the accession number is A0A024R2F2.
| Keywords: | RCA1, HRCA1, VHL1, von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase, pVHL |
| MW: | 27.5 kD |
From 295.00€
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VH-298
Item number: TGM-TQ0121-100mg
Description: VH-298 is a potent inhibitor of VHL that stabilizes HIF-alpha and elicits a hypoxic response via a different mechanism, that is the blockade of the VHL:HIF-alpha protein-protein interaction downstream of HIF-alpha hydroxylation by PHD enzymes. Target: HIF, Ligand for E3 Ligase, Others. Smiles:...
| Application: | Protac(R) reagent |
| CAS | 2097381-85-4 |
| MW: | 523.65 D |
From 40.00€
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