102 products were found matching "K03163"!

Organism: Homo sapiens (Human). Source: Baculovirus. Expression Region: 190-765aa. Protein Length: Partial. Tag Info: N-terminal 10xHis-tagged and C-terminal Myc-tagged. Target Protein Sequence: NKKKKPKKEE EQKWKWWEEE RYPEGIKWKF LEHKGPVFAP PYEPLPENVK FYYDGKVMKL SPKAEEVATF FAKMLDHEYT TKEIFRKNFF KDWRKEMTNE EKNIITNLSK...

Organism: Homo sapiens (Human). Source: Baculovirus. Expression Region: 190-765aa. Protein Length: Partial. Tag Info: C-terminal 6xHis-tagged. Target Protein Sequence: NKKKKPKKEE EQKWKWWEEE RYPEGIKWKF LEHKGPVFAP PYEPLPENVK FYYDGKVMKL SPKAEEVATF FAKMLDHEYT TKEIFRKNFF KDWRKEMTNE EKNIITNLSK CDFTQMSQYF KAQTEARKQM...

Exatecan is a derivative of camptothecin (Cay-11694) and DNA topoisomerase I inhibitor (IC50 = 0.975 µg/ml). It inhibits cell growth in a panel of 32 breast, colon, stomach, and lung cancer cell lines (GI50s = 0.125-10.4 ng/ml). Exatecan (3.325-50 mg/kg) reduces tumor growth in an SC-6-JCK gastric adenocarcinoma...

DNA topoisomerases relax DNA torsional strain created during replication, transcription, recombination, repair, and chromosome condensation. The relaxation of DNA supercoiling by topoisomerase I at single-strand breaks enables anticancer agents to reversibly trap the complex by intercalating between DNA base pairs...

SN-38-d3 is intended for use as an internal standard for the quantification of SN-38 (Cay-15632) by GC- or LC-MS. SN-38 is an inhibitor of topoisomerase I and an active metabolite of the prodrug irinotecan (Cay-14180). It is formed from irinotecan by carboxylesterases. SN-38 (0.1, 1, and 10 µM) induces topoisomerase...

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human TOP1. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human TOP1. Next,...

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Rat TOP1. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Rat TOP1. Next,...

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse TOP1. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse TOP1. Next,...

Topotecan is an inhibitor of DNA topoisomerase I and a derivative of the DNA topoisomerase I inhibitor camptothecin (Cay-11694). Topotecan inhibits DNA topoisomerase I in human MCF-7 breast and DU-145 prostate cancer cells with IC50 values of 13 and 2 nM, respectively, in a cell-based luciferase reporter assay....

SN-38 is an inhibitor of topoisomerase I and an active metabolite of the prodrug irinotecan (Cay-14180). It is formed from irinotecan by carboxylesterases. SN-38 (0.1, 1, and 10 µM) induces topoisomerase I-dependent DNA cleavage in a cell-free assay. It induces DNA single-strand breaks in HT-29 colorectal...

Irinotecan, a derivative of the alkaloid camptothecin (Cay-11694), functions as a prodrug that is converted by tissue carboxylesterase to 7-ethyl-10-hydroxycamptothecin, a potent inhibitor of DNA topoisomerase I. Its action is terminated by glucuronidation by UDP glucuronosyl transferase 1A1. Irinotecan demonstrates...

Antibiotic, Weak topoisomerase I (Topo I) inhibitor, Structurally similar to staurosporine, Does not show any inhibitory activity against protein kinases, Shows significant antitumor properties in vitro (IC50 = 480 nM against mouse B16 melanoma cells and IC50 = 500 nM against P388 leukemia cells). Isolated from...