- Search results for K02861
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71 products were found matching "K02861"!
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NEW
Item number: CSB-EP618785HU2.1
Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 1-375aa. Protein Length: Partial. Tag Info: N-terminal 10xHis-tagged and C-terminal Myc-tagged. Target Protein Sequence: MQPDMSLNVI KMKSSDFLES AELDSGGFGK VSLCFHRTQG LMIMKTVYKG PNCIEHNEAL LEEAKMMNRL RHSRVVKLLG VIIEEGKYSL VMEYMEKGNL MHVLKAEMST...
Keywords: | RIP-1, Cell death protein RIP, Receptor-interacting protein 1, Receptor-interacting serine/threonine-protein kinase 1,... |
Application: | Activity not tested |
Expressed in: | E.coli |
Origin: | human |
MW: | 49.4 kD |
From 354.00€
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NEW
Item number: CSB-EP720181MO.1
Organism: Mus musculus (Mouse). Source: E.coli. Expression Region: 1-656aa. Protein Length: Full Length. Tag Info: N-terminal 6xHis-tagged. Target Protein Sequence: MQPDMSLDNI KMASSDLLEK TDLDSGGFGK VSLCYHRSHG FVILKKVYTG PNRAEYNEVL LEEGKMMHRL RHSRVVKLLG IIIEEGNYSL VMEYMEKGNL MHVLKTQIDV PLSLKGRIIV EAIEGMCYLH...
Keywords: | Rinp, RIP-1, Cell death protein RIP, Receptor-interacting protein 1, Receptor-interacting serine/threonine-protein kinase... |
Application: | Activity not tested |
Expressed in: | E.coli |
Origin: | mouse |
MW: | 78.9 kD |
From 213.00€
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NEW
Item number: CSB-EP720181MOa2.1
Organism: Mus musculus (Mouse). Source: E.coli. Expression Region: 1-656aa. Protein Length: Full Length. Tag Info: N-terminal 6xHis-SUMO-tagged. Target Protein Sequence: MQPDMSLDNI KMASSDLLEK TDLDSGGFGK VSLCYHRSHG FVILKKVYTG PNRAEYNEVL LEEGKMMHRL RHSRVVKLLG IIIEEGNYSL VMEYMEKGNL MHVLKTQIDV PLSLKGRIIV EAIEGMCYLH...
Keywords: | Rinp, RIP-1, Cell death protein RIP, Receptor-interacting protein 1, Receptor-interacting serine/threonine-protein kinase... |
Application: | Activity not tested |
Expressed in: | E.coli |
Origin: | mouse |
MW: | 87.8 kD |
From 213.00€
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Item number: Cay11658-5
Necroptosis is a regulated caspase-independent cell death mechanism that results in morphological features resembling necrosis. Serine/threonine kinase activity of the death domain receptor-associated molecule RIP1 is thought to be essential for Fas ligand-induced and tumor necrosis factor-alpha (TNF-alpha) induced...
Keywords: | Nec-1, 5-(1H-indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone |
Application: | RIP1 kinase inhibitor |
CAS | 4311-88-0 |
MW: | 259.3 D |
From 40.00€
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Item number: Cay36653-10
PK68 is an inhibitor of receptor-interacting serine/threonine kinase 1 (RIPK1, IC50 = 90 nM). It is selective for RIPK1 over RIPK3 and a panel of 369 kinases at 1,000 nM. PK68 inhibits necroptosis induced by TNF-alpha, a Smac mimetic, and z-VAD in HT-29 colon cancer cells (EC50 = 23 nM). It reduces the number of...
Keywords: | N-[5-[2-(acetylamino)-6-benzothiazolyl]-2-methyl-3-pyridinyl]-carbamic acid, cyclohexyl ester |
Application: | RIPK1 inhibitor |
CAS | 2173556-69-7 |
MW: | 424.5 D |
From 195.00€
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Item number: Cay39900-10
GSK963 is an inhibitor of receptor-interacting serine/threonine kinase 1 (RIPK1). It is selective for RIPK1 with less than 50% inhibition of 339 kinases in a panel at 10 µM. Unlike the RIPK1 inhibitor necrostatin-1 (Cay-11658), GSK963 is inactive against indolamine-2,3-dioxygenase (IDO). GSK963 inhibits necroptosis...
Keywords: | 1-[(5S)-4,5-dihydro-5-phenyl-1H-pyrazol-1-yl]-2,2-dimethyl-1-propanone |
Application: | RIPK1 inhibitor |
CAS | 2049868-46-2 |
MW: | 230.3 D |
From 111.00€
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Item number: ELK-ELK4588.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human RIPK1. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human RIPK1. Next,...
Keywords: | RIP-1, Cell death protein RIP, Receptor-interacting protein 1, Receptor-interacting serine/threonine-protein kinase 1 |
Application: | ELISA |
Species reactivity: | human |
From 365.00€
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Item number: ELK-ELK7164.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Rat RIPK1. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Rat RIPK1. Next,...
Keywords: | Receptor interacting serine/threonine kinase 1 |
Application: | ELISA |
Species reactivity: | rat |
From 365.00€
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Item number: Cay37347-1
GSK547 is an inhibitor of receptor-interacting serine/threonine kinase 1 (RIPK1, IC50 = 31 nM). It is selective for RIPK1 over a panel of 371 kinases, including RIPK2, -3, -4, and -5, at 10 µM. In vivo, GSK547 (100 mg/kg) increases survival and reduces tumor volume and the number of liver metastases in a P48Cre...
Keywords: | RIP1i, 6-[4-[[(5S)-5-(3,5-difluorophenyl)-4,5-dihydro-1H-pyrazol-1-yl]carbonyl]-1-piperidinyl]-4-pyrimidinecarbonitrile |
Application: | RIPK1 inhibitor |
CAS | 2226735-55-1 |
MW: | 396.4 D |
From 40.00€
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Item number: Cay20924-1
(±)-Necrostatin-2 is a racemic mixture that inhibits receptor-interacting protein kinase 1 (RIPK1) autophosphorylation in vitro in a dose-dependent manner. Treatment with 6 mg/kg/day of (±)-necrostatin-2 prevents TNF-induced mortality in a murine model of systemic inflammatory response syndrome (SIRS)....
Keywords: | 7-Cl-O-Nec-1, Nec-1s, 5-[(7-chloro-1H-indol-3-yl)methyl]-3-methyl-2,4-imidazolidinedione |
Application: | Cell-permeable RIP1 inhibitor |
CAS | 852391-15-2 |
MW: | 277.7 D |
From 54.00€
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Item number: Cay38494-1
SZM-1209 is an inhibitor of receptor-interacting serine/threonine kinase 1 (RIPK1). It selectively binds to RIPK1 over RIPK3 (Kds = 85 and >10,000 nM, respectively) and inhibits necrosome formation and phosphorylation of RIPK1 induced by TNF-alpha, SM-164 (Cay-28632), and Z-VAD-FMK in HT-29 cells (EC50 = 22.4 nM)....
Keywords: | N-[5-[[2-[[[4-[(ethylsulfonyl)amino]cyclohexyl]carbonyl]amino]-5-fluoro-6-benzothiazolyl]oxy]-2-fluorophenyl]-3-(trifluoro... |
Application: | RIPK1 inhibitor |
CAS | 2919801-86-6 |
MW: | 696.7 D |
From 104.00€
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Item number: Cay21192-50
Necrostatin-1 Inactive Control (Nec-1i) is a demethylated variant of necrostatin-1 (Nec-1, Cay-11658), a RIP1 kinase inhibitor. While both Nec-1 and Nec-1i inhibit the immune regulator indoleamine 2,3-dioxygenase, Nec1i is ~100-fold less effective than Nec-1 in inhibiting RIP1 kinase in vitro and 10-fold less potent...
Keywords: | Nec-1i, 5-(1H-indol-3-ylmethyl)-2-thioxo-4-imidazolidinone |
Application: | Inactive RIPK1 inhibitor control |
CAS | 64419-92-7 |
MW: | 245.3 D |
From 46.00€
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