77 products were found matching "K02737"!
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Proteasome inhibitor IX
Item number: TGM-T21854-100mg
Description: Proteasome inhibitor IX (PS-IX) is an inhibitor of chymotrypsin-like activity of the 20S proteasome (IC50 ~1 µM). Proteasome inhibitor IX shows potent anticancer activity. Proteasome inhibitor IX exhibits HCT116 p53+/+ cells growth inhibitory activity(IC50 = 1.49 µM). Target: Proteasome. Smiles:...
| Keywords: | PS-IX, AM114 |
| Application: | Proteasome inhibitor |
| CAS | 856849-35-9 |
| MW: | 377.01 D |
From 33.00€
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Ixazomib citrate
Item number: TGM-T8397-10mg
Description: Ixazomib citrate (MLN9708) is a prodrug of Ixazomib (MLN-2238) and an orally bioavailable second-generation proteasome inhibitor with an IC50 of 3.4 nM, exhibiting potential antineoplastic activity. Target: Proteasome, Autophagy. Smiles:...
| Keywords: | MLN9708 |
| Application: | Targets 20S proteasome subunit beta 5 [EC:3.4.25.1] (PSMB5) |
| CAS | 1239908-20-3 |
| MW: | 517.12 D |
From 43.00€
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Lactacystin
Item number: TGM-T15702-1mg
Description: Lactacystin is an antibiotic Streptomyces spp. the metabolite and is an effective and selective proteasome inhibitor (IC50: 4.8 µM for 20S proteasome). Lactacystin inhibits cell growth and induces neurite outgrowth and also inhibits the lysosomal enzyme cathepsin A. Target: Proteasome. Smiles:...
| Application: | Irreversible proteasome inhibitor |
| CAS | 133343-34-7 |
| MW: | 376.43 D |
From 86.00€
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MG-115
Item number: TGM-T21617-100mg
Description: MG-115 (Z-LL-Nva-CHO) is a potent and reversible inhibitor of proteasome , with K i s of 21 nM and 35 nM for 20S and 26S proteasome, respectively. MG-115 specifically inhibit the chymotrypsin-like activity of the proteasome, induces p53-dependent apoptosis [1] [2] [3]. Target: Proteasome. Smiles:...
| Keywords: | Z-LL-Nva-CHO |
| Application: | Potent, reversible proteasome chymotrypsin-like activity inhibitor |
| CAS | 133407-86-0 |
| MW: | 461.59 D |
From 95.00€
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Ixazomib
Item number: TGM-T2122-1mg
Description: Ixazomib (MLN2238) , a second generation, boron-containing peptide proteasome inhibitor (PI), inhibits the chymotrypsin-like proteolytic (beta5) site of the 20S proteasome (IC50/Ki: 3.4/0.93 nM, in cell-free assays), also inhibits the caspase-like (beta1) and trypsin-like (beta2) proteolytic sites...
| Keywords: | MLN2238 |
| Application: | Targets 20S proteasome subunit beta 5 [EC:3.4.25.1] (PSMB5) |
| CAS | 1072833-77-2 |
| MW: | 361.03 D |
From 41.00€
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Tripterin
Item number: TGM-T3028-100mg
Description: Tripterin (Celastrol) is a natural product, a proteasome inhibitor that inhibits the pancreatic rennet-like activity of the 20S proteasome (IC50=2.5 µM). Tripterin has anti-inflammatory, anti-infectious, and immunomodulatory properties. Target: Mitophagy, Apoptosis, Autophagy, Proteasome. Smiles:...
| Keywords: | Tripterine, Celastrol |
| Application: | Antiobesity agent, 20S proteasome chymotrypsin-like activity inhibitor |
| CAS | 34157-83-0 |
| MW: | 450.61 D |
From 46.00€
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Z-LLL-AMC
Item number: TGM-T37418-5mg
Description: Z-LLL-AMC is a fluorogenic substrate for the chymotrypsin-like activity of the 26S proteasome or 20S proteolytic core. Chymotrypsin-like activity can be quantified by fluorescent detection of free AMC (also known as 7-amino-4-methylcoumarin), which is excited at 340-360 nm and emits at 440-460 nm....
| Application: | Fluorogenic proteasome chymotrypsin-like protease activity substrate |
| CAS | 152015-61-7 |
| MW: | 648.801 D |
342.00€
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VR23
Item number: TGM-T7016-100mg
Description: VR23 is a potent proteasome inhibitor. Data shows IC50 =1 nM for trypsin-like proteasomes, IC50=50-100 nM for chymotrypsin-like proteasomes, and IC50=3 µM for caspase-like proteasomes. Target: Proteasome, Apoptosis, Caspase. Smiles:...
| Application: | Proteasome inhibitor |
| CAS | 1624602-30-7 |
| MW: | 477.88 D |
From 43.00€
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Epoxomicin
Item number: TGM-T6830-100mg
Description: Epoxomicin (BU-4061T,Aids010837) is a selective proteasome inhibitor with anti-inflammatory activity, inhibits primarily the CH-L activity of the 20S proteasome, while T-L and PGPH catalytic activities are also inhibited at 100- and 1000-fold reduced rate. Target: Apoptosis, Proteasome. Smiles:...
| Keywords: | BU-4061T, BU-4061T,Aids010837 |
| Application: | Antibiotic, anticancer compound, Cell-permeable irreversible 20S proteasome inhibitor |
| CAS | 134381-21-8 |
| MW: | 554.72 D |
From 124.00€
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PI-1840
Item number: TGM-T6941-100mg
Description: PI-1840(IC50 = 27 nM)is a reversible and selective chymotrypsin-like (CT-L) inhibitor, with little proteasome proteolytic effects on trypsin-like (T-L) and postglutamyl-peptide-hydrolysis-like (PGPH-L). Target: PARP, Proteasome. Smiles: CCCc1ccc(OCC(=O)N(Cc2nc(no2)-c2cccnc2)C(C)C)cc1. References: Ozcan...
| Keywords: | PI 1840 |
| Application: | Proteasome inhibitor |
| CAS | 1401223-22-0 |
| MW: | 394.47 D |
From 53.00€
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Suc-Leu-Leu-Val-Tyr-AMC
Item number: TGM-TP1308-10mg
Description: Suc-Leu-Leu-Val-Tyr-AMC is a fluorescent substrate for the 20S proteasome, as well as other chymotrypsin-like proteases (20S-proteasome/chymotrypsin). Smiles: CC(C)C[C@H](NC(=O)CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)Nc1ccc2c(C)cc(=O)oc2c1. References: Roberta L....
| Application: | Fluorogenic proteasome substrate |
| CAS | 94367-21-2 |
| MW: | 763.88 D |
From 83.00€
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Lactacystin
Item number: Cay70980-100
Lactacystin is a microbial metabolite isolated from Streptomyces that is now widely used as a selective inhibitor of the 20S proteasome. Lactacystin was first characterized by its ability to induce differentiation and inhibit cell cycle progression in several tumor cell lines. At concentrations from 2 to 10 µM,...
| Keywords: | 3S-hydroxy-2R-(1-hydroxy-2-methylpropyl)-4R-methyl-5-oxo-2-pyrrolidinecarboxylate-N-acetyl-L-cysteine |
| Application: | 20S proteasome inhibitor |
| CAS | 133343-34-7 |
| MW: | 376.4 D |
From 48.00€
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