181 products were found matching "K02677"!
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Phorbol 12-myristate 13-acetate
Item number: Cay10008014-1
Phorbol 12-myristate 13-acetate (PMA), also known as 12-O-tetradecanoylphorbol 13-acetate (TPA), is a phorbol ester and PKC activator. It activates the PKC isoforms PKCalpha, -beta, -gamma, -delta, -epsilon, -eta, and -theta but not PKCzeta or -iota/lambda. PMA (1-10 ng/ml) induces NF-kappaB-dependent gene...
| Keywords: | 12-O-Tetradecanoylphorbol-13-acetate, PMA, TPA, tetradecanoic acid,... |
| Application: | PKC activator |
| CAS | 16561-29-8 |
| MW: | 616.8 D |
From 52.00€
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Phorbol 12-myristate 13-acetate
Item number: AG-CN2-0010-M001
Most commonly-used phorbol ester, Binds to and activates protein kinase C (PKC) at nM concentrations, Induces cell growth arrest through a variety of pathways including the mitogen-activated protein kinases (MAPKs), p38 and c-Jun N-terminal kinase (JNK) pathways mediated by cyclin dependent kinase (CDK) inhibitors...
| Keywords: | PMA, TPA, 12-O-Tetradecanoylphorbol 13-acetate |
| Application: | PKC activator |
| CAS | 16561-29-8 |
| MW: | 616,8 D |
From 44.00€
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Staurosporine
Item number: LKT-S7600.1
A protein kinase C inhibitor which induces apoptosis in many cell types. Experimental results obtained in a cell -free assay suggest that cytoplasmic proteins directly modulated by staurosporine may be involved in signaling the induction of DNA fragmentation and apoptosis.
| Keywords: | AM-2282, STS |
| Application: | PKC inhibitor |
| CAS | 62996-74-1 |
| MW: | 466,5 D |
From 63.00€
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Staurosporine
Item number: Cay81590-1
Staurosporine (Stsp) is potent inhibitor of protein kinase C (PKC) from rat brain, exhibiting an IC50 value of 2.7 nM. It inhibits rat recombinant PKC-alpha approximately 100- and 1,000-fold better than PKC-delta and PKC-zeta, respectively. However, Stsp is non-selective in that it also inhibits the activity of a...
| Keywords: | Stsp,... |
| Application: | PKC inhibitor |
| CAS | 62996-74-1 |
| MW: | 466.5 D |
From 44.00€
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Staurosporine
Item number: AG-CN2-0022-M001
Isolated from Streptomyces spiralis. Antibiotic. Antifungal and anti-yeast activity. Inhibits platelet aggregation induced by collagen or ADP. Has no effect on thrombin-induced platelet aggregation. Potent, cell permeable, reversible, ATP-competitive and broad spectrum inhibitor of protein kinases. Inhibits protein...
| Keywords: | Antibiotic AM2282, Antibiotic 230, CCRIS 3272 |
| Application: | Protein kinase inhibitor, Apoptosis inducer |
| CAS | 62996-74-1 |
| MW: | 466,5 D |
From 33.00€
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K252d
Item number: TGM-T71530-1mg
Description: K252d is an indolocarbazole alkaloid found in Nocardiopsis. It is a PKC inhibitor that inhibits PKC isolated from rat brain, as well as, calcium- and calmodulin-dependent phosphodiesterase isolated from bovine heart. Target: Others. Smiles:...
| Application: | Indolocarbazole alkaloid, PKC inhibitor |
| CAS | 105114-22-5 |
| MW: | 457.48 D |
787.00€
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Hypericin
Item number: TGM-T6S0923-100mg
Description: 1. Hypericin (Cyclosan) has antineoplastic activity. 2. Hypericin has antibiotic and antiviral activities. 3. Hypericin has antidepressive activity through inhibiting monoamine oxidase enzyme. 4. Hypericin inhibits RANKL-mediated osteoclastogenesis via affecting ERK signalling in vitro and suppresses...
| Keywords: | Hypericine, Cyclosan |
| Application: | PKC inhibitor |
| CAS | 548-04-9 |
| MW: | 504.44 D |
From 52.00€
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Bisindolylmaleimide IV
Item number: TGM-T7659-100mg
Description: Bisindolylmaleimide IV is a protein kinase C (PKC) cell permeable inhibitor( IC50 : 0.10 - 0.55 µM). Target: PKC, Others. Smiles: O=C1NC(=O)C(C2=CNC3=CC=CC=C23)=C1C1=CNC2=CC=CC=C12. References: Toullec D , Pianetti P , Coste H , et al. The bisindolylmaleimide GF 109203X is a potent and selective...
| Application: | PKC/PKA inhibitor |
| CAS | 119139-23-0 |
| MW: | 327.34 D |
From 42.00€
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Bisindolylmaleimide III
Item number: TGM-T77628-100mg
Description: Bisindolylmaleimide III is a potent and selective inhibitor of protein kinase C (PKC), specifically interacting with PKCalpha or ribosomal S6 protein kinase 1 upon activation of these kinases. Target: PKC. Smiles: O=C1C(=C(C(=O)N1)C=2C=3C(NC2)=CC=CC3)C=4C=5C(N(CCCN)C4)=CC=CC5. References: Brehmer D, et...
| Application: | PKC inhibitor |
| CAS | 137592-43-9 |
| MW: | 384.43 D |
From 71.00€
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Phorbol 12-myristate 13-acetate
Item number: TGM-TQ0198-10mg
Description: Phorbol 12-myristate 13-acetate (PMA), a member of the phorbol ester group of natural products, activates PKC, SphK, and NF-kappaB, and induces THP1 cell differentiation. Target: PKC, S1P Receptor, NF-kappaB. Smiles:...
| Keywords: | PMA |
| Application: | PKC activator |
| CAS | 16561-29-8 |
| MW: | 616.83 D |
From 45.00€
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Ro 31-8220 Mesylate
Item number: TGM-T6643-100mg
Description: Ro 31-8220 Mesylate (Bisindolylmaleimide IX mesylate) is a pan-PKC inhibitor for PKC-alpha/betaI/betaII/gamma/epsilon (IC50: 5/24/14/27/24 nM), and also shows potent inhibition against MSK1, MAPKAP-K1b, S6K1, and GSK3beta. Target: PKC. Smiles:...
| Keywords: | Bisindolylmaleimide IX mesylate, Ro 31-8220 methanesulfonate, Bisindolylmaleimide IX |
| Application: | PKC inhibitor |
| CAS | 138489-18-6 |
| MW: | 553.65 D |
From 45.00€
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Staurosporine
Item number: TGM-T6680-100mg
Description: Staurosporine (AM-2282) is a protein kinase inhibitor with ATP-competitive and non-selective inhibitory activity (IC50=6/15/2/3/3000 nM) against PKC, PKA, c-Fgr, phosphorylase kinase and TAOK2. Staurosporine also induces apoptosis. Target: Antifungal, PKC, Src, Antibacterial, Apoptosis, Antibiotic,...
| Keywords: | CGP 41251, AM-2282, Antibiotic AM-2282 |
| Application: | Protein kinase inhibitor, Apoptosis inducer |
| CAS | 62996-74-1 |
| MW: | 466.53 D |
From 57.00€
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