115 products were found matching "K02539"!
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Anti-Mcl-1 (Myeloid Cell Leukemia-1)
Item number: 600-401-394
Protein function: Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. [The UniProt Consortium]
| Keywords: | Anti-Mcl1, Anti-Bcl-2-related protein EAT/mcl1, Anti-Induced myeloid leukemia cell differentiation protein Mcl-1 homolog |
| Application: | ELISA, WB |
| Host: | Rabbit |
| Species reactivity: | mouse |
684.00€
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Mcl-1 inhibitor 3
Item number: TGM-T11972-25mg
Description: Mcl-1 inhibitor 3 shows good pharmacokinetic properties and excellent in vivo efficacy without toxicity.Mcl-1 inhibitor 3 is a highly potent and orally activate macrocyclic Mcl-1 inhibitor (Ki= 0.061 nM, IC50=19 nM in an OPM-2 cell viability assay). Target: BCL. Smiles:...
| Application: | Mcl-1 inhibitor |
| CAS | 2376774-73-9 |
| MW: | 820.39 D |
1,491.00€
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MIM1
Item number: TGM-T12041-10mg
Description: MIM1 (Inhibitor of Mcl-1) is an myeloid cell factor 1 (Mcl-1) inhibitor. Target: BCL. Smiles: Cc1cs\c(=N\C2CCCCC2)n1\N=C\c1ccc(O)c(O)c1O. References: Vidomanova E, et al. Microfluidic profiling of apoptosis-related genes after treatment with BH3-mimetic agents in astrocyte and glioblastoma cell lines....
| Keywords: | Inhibitor of Mcl-1 |
| Application: | Selective MCL-1 ligand |
| CAS | 509102-00-5 |
| MW: | 347.43 D |
From 32.00€
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MIK665
Item number: TGM-T12629L-100mg
Description: MIK665 (S-64315) (S-64315) has an inhibitory effect on myeloid leukemia. Target: BCL. Smiles: COc1ccccc1-c1nccc(COc2ccccc2C[C@@H](Oc2ncnc3sc(c(-c4ccc(OCCN5CCN(C)CC5)c(Cl)c4C)c23)-c2ccc(F)cc2)C(O)=O)n1. References: Zoltán SZLÁVIK, et al. New hydroxyester derivatives, a process for their preparation and...
| Keywords: | S-64315 |
| Application: | Mcl-1 inhibitor |
| CAS | 1799631-75-6 |
| MW: | 875.41 D |
From 132.00€
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VU0661013
Item number: TGM-T17247-100mg
Description: VU0661013 is an effective and selective inhibitor of MCL-1. Target: BCL. Smiles: C[C@@H]1CN(c2cn(C)c3ccc(cc23)C(O)=O)C(=O)c2c(CCCOc3cc(C)c(Cl)c(C)c3)c3ccc(Cl)c(-c4c(C)nn(C)c4C)c3n12. References: Haley E. Ramsey, et al. A Novel MCL-1 Inhibitor Combined with Venetoclax Rescues Venetoclax Resistant Acute...
| Keywords: | VU661013 |
| Application: | Mcl-1 inhibitor |
| CAS | 2131184-57-9 |
| MW: | 712.66 D |
From 105.00€
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BT2
Item number: TGM-T14834-100mg
Description: BT2, a BCKDC kinase (BDK) inhibitor, exhibits an IC50 of 3.19 µM and functions as a potent, selective Mcl-1 inhibitor with a Ki value of 59 µM. Its interaction with BDK induces helix movements in the N-terminal domain, leading to BDK's dissociation from the branched-chain alpha-ketoacid dehydrogenase...
| Application: | Mcl-1 inhibitor |
| CAS | 34576-94-8 |
| MW: | 247.1 D |
From 38.00€
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Tapotoclax
Item number: TGM-T14213-1mg
Description: AMG-176 is a MCL-1 inhibitor (Ki: 0.13 nM). Target: BCL. Smiles: [H][C@@]12CC[C@@]1([H])[C@@H](OC)\C=C\C[C@H](C)[C@@H](C)S(=O)(=O)NC(=O)c1ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C2)c3c1. References: Caenepeel S, et al. AMG 176, a Selective MCL1 Inhibitor, is Effective in Hematological Cancer Models Alone and in...
| Keywords: | AMG-176 |
| Application: | Targets myeloid leukemia cell differntiation protein MCL-1 (MCL1) |
| CAS | 1883727-34-1 |
| MW: | 613.21 D |
979.00€
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Homoharringtonine
Item number: TGM-T3380-100mg
Description: Homoharringtonine (HHT) is a natural alkaloid that inhibits the translation of proteins and is cytotoxic. Homoharringtonine acts on the ribosomes of tumor cells to inhibit the elongation step of protein translation, thereby inhibiting protein synthesis, and has antitumor activity. Target: STAT. Smiles:...
| Keywords: | Myelostat, HHT, Omacetaxine mepesuccinate, Ceflatonin |
| Application: | Targets G1/S-specific cyclin-D1 (CCND1) |
| CAS | 26833-87-4 |
| MW: | 545.62 D |
From 50.00€
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A-1210477
Item number: TGM-T2632-2mg
Description: A-1210477 is an effective and specific MCL-1 and Bcl-2 inhibitor (Ki/IC50: 0.454/26.2 nM). Target: Apoptosis, BCL. Smiles: C(CN1CCOCC1)N2C3=C(C=CC=C3C(CCCOC=4C5=C(C=CC4)C=CC=C5)=C2C(O)=O)C6=C(COC7=CC=C(C=C7)N8CCN(S(N(C)C)(=O)=O)CC8)N(C)N=C6C. References: Leverson JD, et al. Cell Death Dis. 2015,...
| Application: | Mcl-1 inhibitor |
| CAS | 1668553-26-1 |
| MW: | 850.04 D |
From 34.00€
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ML311
Item number: TGM-T5108-100mg
Description: ML311 is a selective inhibitor of the Mcl-1/Bim interaction. Target: BCL. Smiles: CCN1CCN(CC1)C(c1ccc(cc1)C(F)(F)F)c1ccc2cccnc2c1O. References: Bannister T, et al. ML311: A Small Molecule that Potently and Selectively Disrupts the Protein-Protein Interaction of Mcl-1 and Bim: A Probe for Studying...
| Application: | Mcl-1 inhibitor |
| CAS | 315698-17-0 |
| MW: | 415.45 D |
From 36.00€
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UMI-77
Item number: TGM-T6034-100mg
Description: UMI-77, a specific Mcl-1 inhibitor (Ki: 490 nM), has selectivity over other members of Bcl-2 family. Target: BCL. Smiles: OC(=O)CSc1cc(NS(=O)(=O)c2ccc(Br)cc2)c2ccccc2c1O. References: Abulwerdi F, et al. Mol Cancer Ther. 2014, 13(3), 565-575.
| Keywords: | UMI 77, UMI77 |
| Application: | Mcl-1 inhibitor |
| CAS | 518303-20-3 |
| MW: | 468.34 D |
From 36.00€
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S63845
Item number: TGM-T5346-10mg
Description: S63845 is a selective MCL-1 inhibitor(Kd: 0.19 nM). Target: BCL. Smiles: CN1CCN(CCOc2ccc(-c3c(sc4ncnc(O[C@@H](Cc5ccccc5OCc5ccnn5CC(F)(F)F)C(O)=O)c34)-c3ccc(F)o3)c(C)c2Cl)CC1. References: András Kotschy, Zoltán Szlavik, James Murray.The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer...
| Application: | Mcl-1 inhibitor |
| CAS | 1799633-27-4 |
| MW: | 829.26 D |
From 78.00€
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